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Questions and Answers
What conditions are associated with Microcytic, Hypochromic anemia? (Select all that apply)
What conditions are associated with Microcytic, Hypochromic anemia? (Select all that apply)
- Thalassemia (correct)
- Iron deficiency anemia (correct)
- Macrocytic anemia
- Sideroblastic anemia (correct)
- Lead exposure (correct)
- Anemia of chronic disease (correct)
What is indicated by a Macrocytic anemia with RPI > 3?
What is indicated by a Macrocytic anemia with RPI > 3?
- Hemolytic anemia (correct)
- Chronic disease anemia
- Iron deficiency anemia
- Thalassemia
What conditions are indicated by Macrocytic anemia with RPI = 3? (Select all that apply)
What conditions are indicated by Macrocytic anemia with RPI = 3? (Select all that apply)
- Sideroblastic anemia
- Hemorrhage (Blood loss anemia) (correct)
- Hemolytic anemia (intrinsic) (correct)
- Hemolytic anemia (extrinsic) (correct)
Define Normocytic, Normochromic anemia.
Define Normocytic, Normochromic anemia.
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Study Notes
Microcytic, Hypochromic Anemia
- Characterized by small-sized red blood cells and low hemoglobin concentration
- Relevant conditions include:
- Sideroblastic anemia
- Iron deficiency anemia
- Anemia of chronic disease or inflammation
- Thalassemia
- Lead exposure
- Reticulocyte Production Index (RPI) of 3 indicates adequate marrow response
Macrocytic Anemia (RPI >3)
- Characterized by large-sized red blood cells
- Associated with conditions such as:
- Hemolytic anemia or hemorrhage
- Presence of polychromasia, indicating reticulocyte release in response to hemolysis
Macrocytic Anemia (RPI = 3)
- Blood loss anemia can cause macrocytosis without significant marrow response
- May exhibit variable red blood cell morphology
- Causes of extrinsic hemolytic anemia include:
- Microangiopathic hemolytic anemia (MAHA) due to disseminated intravascular coagulation (DIC), thrombotic thrombocytopenic purpura (TTP), or hemolytic uremic syndrome (HUS)
- Autoimmune conditions leading to hemolysis
- Intrinsic hemolytic causes involve:
- RBC membrane defects
- Enzyme deficiencies
- Hemoglobinopathies
- Paroxysmal nocturnal hemoglobinuria (PNH)
Normocytic, Normochromic Anemia
- Defined by red blood cells that are normal in size and hemoglobin content
- Specific cases or causes not fully detailed in provided information
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