Morphine Pharmacokinetics and Adverse Reactions Quiz
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Questions and Answers

What is a common side effect of morphine due to the release of histamine from mast cells?

  • Hypertension
  • Bronchodilation
  • Bradycardia (correct)
  • Tachycardia
  • Which gastrointestinal effect is associated with opioid analgesics like morphine?

  • Constipation (correct)
  • Decreased ileocaecal sphincter spasm
  • Relaxation of pyloric sphincter
  • Increased intestinal secretions
  • What is a notable effect of opioids in the CNS that may interfere with ventilation?

  • Truncal rigidity (correct)
  • Sedation
  • Euphoria
  • Antitussive action
  • Which of the following is a common symptom caused by the stimulation of opioid receptors in the chemoreceptor trigger zone (CTZ)?

    <p>Nausea and vomiting</p> Signup and view all the answers

    Which opioid is specifically mentioned for its antitussive (cough suppressant) action?

    <p>Codeine</p> Signup and view all the answers

    In case of morphine poisoning, what is a common treatment strategy to counteract the effects?

    <p>Use an opioid antagonist like naloxone</p> Signup and view all the answers

    What is the active metabolite of morphine?

    <p>Morphine-6-glucuronide</p> Signup and view all the answers

    Which opioid is a selective cough suppressant and has good oral bioavailability?

    <p>Codeine</p> Signup and view all the answers

    What is the acute lethal dose of morphine in humans?

    <p>250 mg</p> Signup and view all the answers

    In case of adverse drug reactions to morphine, what is the specific antidote mentioned in the text?

    <p>Naloxone</p> Signup and view all the answers

    What is a common treatment for morphine poisoning according to the text?

    <p>Gastric lavage</p> Signup and view all the answers

    What enzyme is responsible for the metabolic activation of codeine to morphine?

    <p>CYP2D6</p> Signup and view all the answers

    Which drug is commonly used in combination with paracetamol, aspirin, or ibuprofen to treat moderate to severe pain?

    <p>Hydrocodone</p> Signup and view all the answers

    What is the primary adverse effect of an overdose of pethidine?

    <p>Convulsions</p> Signup and view all the answers

    Which opioid is 80-100 times more potent than morphine?

    <p>Fentanyl</p> Signup and view all the answers

    What is the common use of codeine as a medication?

    <p>Antitussive</p> Signup and view all the answers

    What is the half-life of buprenorphine?

    <p>~12 hours</p> Signup and view all the answers

    Which receptor agonists are being considered for future opioid development due to their potential to provide analgesia without causing addiction?

    <p>Kappa (κ)</p> Signup and view all the answers

    What are the excitatory effects observed in an overdose of pethidine?

    <p>Tremors, mydriasis, hyperreflexia</p> Signup and view all the answers

    What distinguishes opioids as strong analgesics?

    <p>Relieving severe pain</p> Signup and view all the answers

    'Visceral pain' is a significant indication for the use of opioids; what does this term generally refer to?

    <p>'Pain originating from the internal organs'</p> Signup and view all the answers

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