Monoclonal Antibodies

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Questions and Answers

Which cells are fused with myeloma cells to produce monoclonal antibodies?

B cells (correct)
Plasma cells
Natural killer cells
T cells

What is the advantage of using myeloma cells in the fusion process?

They produce antibodies of desired specificity
They are easier to obtain from animals
They have a longer life span in vitro
They can be propagated indefinitely in tissue culture (correct)

What is the result of fusing B cells with myeloma cells?

The myeloma cells lose their ability to grow in the presence of a certain toxic drug
The myeloma cells acquire the short life span of B cells
The B cells lose their ability to produce antibodies
The B cells acquire the immortal property of myeloma tumor (correct)

Which technique is used to generate monoclonal antibodies that are less immunogenic and more suitable for administration to humans?

Replacing the Ig genes of mice with human antibody genes and immunizing the mice with an antigen (B) Signup and view all the answers

Which of the following is a problem with injecting mouse monoclonal antibodies into human subjects?

The human immune system sees the mouse Ig as foreign and mounts an immune response against the injected antibodies (A) Signup and view all the answers