Monoclonal Antibodies
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Questions and Answers

Which cells are fused with myeloma cells to produce monoclonal antibodies?

  • B cells (correct)
  • Plasma cells
  • Natural killer cells
  • T cells

    • What is the advantage of using myeloma cells in the fusion process?

  • They produce antibodies of desired specificity
  • They are easier to obtain from animals
  • They have a longer life span in vitro
  • They can be propagated indefinitely in tissue culture (correct)

    • What is the result of fusing B cells with myeloma cells?

  • The myeloma cells lose their ability to grow in the presence of a certain toxic drug
  • The myeloma cells acquire the short life span of B cells
  • The B cells lose their ability to produce antibodies
  • The B cells acquire the immortal property of myeloma tumor (correct)

    • Which technique is used to generate monoclonal antibodies that are less immunogenic and more suitable for administration to humans?

    <p>Replacing the Ig genes of mice with human antibody genes and immunizing the mice with an antigen</p> Signup and view all the answers

    Which of the following is a problem with injecting mouse monoclonal antibodies into human subjects?

    <p>The human immune system sees the mouse Ig as foreign and mounts an immune response against the injected antibodies</p> Signup and view all the answers

    How are monoclonal antibodies generated using recombinant DNA technology?

    <p>By cloning the DNA encoding human antibodies of desired specificity</p> Signup and view all the answers

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