16 Questions
What was the approximate size of the human genome sequenced by the Human Genome Project?
3,200,000,000 nucleotides
Who completed the first draft of the Human Genome in June 2000?
Francis Collins
What is the approximate number of genes in Rice?
~37,500 genes
What is the size of the genome of P. japonica?
149 billion bases
Who led one of the groups that completed the Human Genome Project?
Craig Venter
What is the size of the genome of E. intestinalis?
2.25 million bases
What is the approximate number of protein coding genes in dogs?
~19,300 genes
Which DNA variation type is used in cancer and identity testing?
Variable Number Tandem Repeats (VNTRs)
What is the median (mean) size of Copy-Number Variations (CNV)?
34kb
Who stated 'We are all mutants' in April 2010?
Francis Collins
What is the average number of SNVs per genome? (in 2010)
~3.5 million
What is the approximate percentage of DNA sequence similarity between humans?
~99.0%
What is the result of a genetic variant that is 'Probably Not Disease Causing' and seen often in population databases?
Benign
What is the type of mutation associated with DiGeorge Syndrome?
22q11.2 deletion
Which DNA variation type has a resolution of approximately 2kb for deletions and duplications?
(resolution ~2kb)
'Not Benign' genetic variants not seen often in population databases are classified as:
'Clearly Actionable Result'
Explore the pathogenesis of major human diseases and learn about DNA variations and their frequencies in the genomic age. Gain insights into molecular genetics and mutation detection with Benjamin Darbro, M.D., Ph.D., Associate Professor at the University of Iowa Hospitals and Clinics.
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