Genetics: Reading Frame Shift Mutation

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A 'reading frame shift' mutation occurs when:

Pyrimidine is replaced by purine.

One or more nucleotides is deleted or inserted (not a multiple of three). (correct)

The number of repetitive sequences in the gene is increased.

All the options listed are suitable.

What is polyploidy?

Chromosome number change by a repeated set of chromosomes.

Chromosome number change with the number of certain chromosomes. (correct)

Chromosome structural changes.

There is no correct answer.

The severe form of alpha-1 antitrypsin deficiency is the result of a single nucleotide leading to a single amino acid substitution. This is best described as a:

Nonsense mutation

Splice-site mutation

Frameshift mutation

Missense mutation (correct)

Adenine is replaced by thymine. What is this nucleotide substitution called?

Transversion Signup and view all the answers

Which of the following is an example of monosomy?

45,X Signup and view all the answers

A fetus with a karyotype of 92, XXXX has which type of mutation and what is the sex of the fetus?

Polyploidy, female sex Signup and view all the answers

Adenine was replaced by guanine. What type of nucleotide substitution is this?

Transition Signup and view all the answers

Child karyotype 47, XX, + 21. What is this mutation and when did it oeeur?

Aneuploidy, during parental gametogenesis Signup and view all the answers

What is the name of the chromosome mutation that involves two breaks on a chromosome followed by a 180-degree turn of the segment and reinsertion at its original breakpoints?

Inversion Signup and view all the answers

A 'reading frame' shift mutation occurs when:

One or more nucleotides is inserted or deleted (not a multiple of three). Signup and view all the answers

In a karyotype of 46 XX, how many Barr bodies will be present in the interphase nucleus of somatic cells?

one Signup and view all the answers

The karyotype 46,XX del(5p) indicates which of the following?

5 autosome short arm deletion Signup and view all the answers

Which of the following changes is a transversion base substitution?

Adenine is replaced by thymine Signup and view all the answers

what is neutral mutation

codes for different amino acid which does not change the protein function Signup and view all the answers

Genetics: Reading Frame Shift Mutation

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