32 Questions
What is the main purpose of Organs-on-chips (OoCs)?
To mimic human physiology and maintain tissue-specific functions
What distinguishes OoCs from native tissues and organs?
They are much simpler than native tissues and organs but can serve as effective mimics of human physiology and disease
What are organoids?
Self-organized 3D tissue cultures derived from stem cells
What does the term 'diagnosis' mean in the context of its etymology?
To discern or observe
What is the purpose of growing organoids?
To better mimic human physiology and maintain tissue-specific functions
What is a key feature of the microfluidic chips used for OoCs?
They contain networks of hair-fine microchannels for guiding and manipulating minute volumes of solution
What is the main advantage of working on the microscale in terms of tissue life support and observation of cell and tissue behavior?
Attaining a higher level of control over the microenvironment and directly observing cell and tissue behavior
What is one of the main applications for Organ-on-a-Chip (OOC) devices mentioned in the text?
Evaluating the safety of drugs prior to entering clinical trials
What is the size of each organ-chip, such as the lung, liver, intestine, or brain, as mentioned in the text?
About the size of flash memory
What does a lab-on-a-chip device primarily aim to achieve based on the information provided?
Integrate laboratory functions on a single chip to handle particles in microfluidic channels
What does Liquid Biopsy (LB) mainly consist of isolating, as mentioned in the text?
Circulating tumor cells (CTCs), circulating tumor DNA (ctDNA), and tumor extracellular vesicles (EVs)
What is one potential benefit of Liquid Biopsy (LB) technology according to the text?
Non-invasive nature enabling accurate detection and continuous monitoring for cancer patients
What do Circulating Tumor Cells (CTCs) primarily account for according to the text?
Travel through the circulatory system and account for metastatic tumors at distal sites
What is one major function of Organs-on-Chips (OoCs) mentioned in the text?
Ability to replicate in vivo physiological conditions accurately
What is the main advantage of studying cell motility using hollow microfluidic channels according to the text?
Lowered fluid volume consumption, increased portability, and reduced cost
What is one key feature that allows researchers to observe organ functionality at a cellular and molecular level?
Transparency of the organ-chip
What is the primary purpose of Organs-on-chips (OoCs) mentioned in the text?
To mimic human physiology and disease outside the body
What distinguishes OoCs from native tissues and organs?
They are much simpler than native tissues and organs
What are organoids?
Tiny, self-organized 3D tissue cultures derived from stem cells
What is one potential benefit of Liquid Biopsy (LB) technology according to the text?
Isolation of circulating tumor cells
What is the main purpose of growing organoids?
To express selected aspects of an organ like producing only certain types of cells
What does the term 'diagnosis' mean in the context of its etymology?
To discern or observe
What is the main advantage of using microfluidic chips for Organ-on-a-Chip (OoC) technology?
Replicating in vivo physiological conditions accurately
What is one potential benefit of Liquid Biopsy (LB) technology?
Accurate detection and continuous monitoring of cancer in patients
What distinguishes Organs-on-Chips (OoCs) from traditional 2D cultures and simplistic 3D culture models?
Replication of in vivo physiological conditions
What accounts for the development of metastatic tumors according to the text?
Circulating tumor cells (CTCs) traveling through the circulatory system
What is the primary purpose of a lab-on-a-chip device based on the information provided?
Integrating laboratory functions on a single chip
What is one of the main applications for Organ-on-a-Chip (OoC) devices mentioned in the text?
Evaluating the safety of drugs before clinical trials
What does Liquid Biopsy (LB) primarily consist of isolating, as mentioned in the text?
Tumor-derived circulating tumor cells (CTCs)
What is the main advantage of working on the microscale in terms of tissue life support and observation of cell and tissue behavior?
Providing a higher level of control over the microenvironment
What distinguishes Organ-on-a-Chip (OoC) technology from traditional 2D cell cultures according to the text?
Increased accuracy in replicating in vivo physiological conditions
What is one potential benefit of Liquid Biopsy (LB) technology according to the text?
Continuous monitoring and treatment based on precision medicine
Learn about the etymology of the term 'diagnosis' and its significance in molecular diagnosis of human diseases. Explore the concepts presented by Prof. Hussein Sabit in this lecture.
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