Podcast
Questions and Answers
What is the most immediate consequence of a mutation that shifts the reading frame of a gene?
What is the most immediate consequence of a mutation that shifts the reading frame of a gene?
- The protein will have a different number of subunits.
- The protein will lose its prosthetic group.
- The amino acid sequence after the mutation will be altered. (correct)
- The protein will fold to a different 3D structure.
How does a mutation in a gamete potentially impact future generations?
How does a mutation in a gamete potentially impact future generations?
- It will only affect the protein structure of the individual where the mutation takes place.
- It will cause the zygote to divide abnormally.
- It can be inherited by the offspring and affect their proteins. (correct)
- It will cause the gamete not to be viable anymore.
Given that a change in protein primary structure may affect function, what direct impact would be expected due to changes in the external 3D hydrophilic groups of hemoglobin?
Given that a change in protein primary structure may affect function, what direct impact would be expected due to changes in the external 3D hydrophilic groups of hemoglobin?
- Increased $Fe^{2+}$ binding to the heme.
- Reduced oxygen binding capacity of heme group.
- Changes in the shape of the 4 subunits of the protein.
- Interference with hemoglobin's interactions within the red blood cell. (correct)
In the context of sickle cell anemia, how does a mutation in the beta polypeptide chain of hemoglobin primarily cause the disease?
In the context of sickle cell anemia, how does a mutation in the beta polypeptide chain of hemoglobin primarily cause the disease?
What is the direct function of the iron ($Fe^{2+}$) atom within the heme group of hemoglobin?
What is the direct function of the iron ($Fe^{2+}$) atom within the heme group of hemoglobin?
Flashcards
Mutation Effects on Reading Frame
Mutation Effects on Reading Frame
Mutations can disrupt the reading frame of a gene, altering protein synthesis.
Inherited Mutations
Inherited Mutations
Mutations in gamete DNA can be passed to offspring and change protein structure.
Protein Structure Dependence
Protein Structure Dependence
Protein function is directly affected by its primary structure due to amino acid sequence changes.
Sickle Cell Anemia
Sickle Cell Anemia
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Hemoglobin Structure
Hemoglobin Structure
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