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Questions and Answers
What is the definition of a chromatin interaction?
What is the definition of a chromatin interaction?
- Two regions of the genome that are far apart in terms of genomic distance, and are spatially distant in the 3-dimensional cellular nucleus
- Two regions of the genome that are far apart in terms of genomic distance, but are spatially proximate to each other in the 3-dimensional cellular nucleus (correct)
- Two regions of the genome that are close together in terms of genomic distance, and are also spatially proximate to each other in the 3-dimensional cellular nucleus
- Two regions of the genome that are close together in terms of genomic distance, but are spatially distant in the 3-dimensional cellular nucleus
What type of changes in DNA sequence motifs involve micro RNAs, Linc RNAs, RNA editing, and RNA methylation?
What type of changes in DNA sequence motifs involve micro RNAs, Linc RNAs, RNA editing, and RNA methylation?
- Changes in enhancer or repressor sites
- Changes in protein modification sites
- Changes in RNA sequence motifs (correct)
- Changes in transcription factor binding sites
Which transcription factor family is mentioned in the text?
Which transcription factor family is mentioned in the text?
- CCAAT-binding Transcription Factor (CBF)
- CCAAT-disrupting Transcription Factor (CDTF)
- CCAAT-enhancer-binding Proteins (C/EBPs)
- Nuclear Factor I-CCAAT-binding Transcription Factor (NFI-CTF) (correct)
What is the topic of the lecture by Dr. Helen Knight in February 2020?
What is the topic of the lecture by Dr. Helen Knight in February 2020?
What action is requested in the 'Objectives' section?
What action is requested in the 'Objectives' section?
Which factor is NOT listed as a risk factor for breast cancer in the text?
Which factor is NOT listed as a risk factor for breast cancer in the text?
What is the most prevalent cancer in the world according to the text?
What is the most prevalent cancer in the world according to the text?
Which region has the highest rates of breast cancer according to the text?
Which region has the highest rates of breast cancer according to the text?
What is the main focus of the lecture by Dr. Ho Wan Yong?
What is the main focus of the lecture by Dr. Ho Wan Yong?
What is the strongest risk factor for breast cancer?
What is the strongest risk factor for breast cancer?
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Study Notes
Chromatin Interactions and Cancer
- A chromatin interaction is defined as a physical contact between two or more distant regions in the genome.
Epigenetic Modifications
- Changes in DNA sequence motifs involving microRNAs, Linc RNAs, RNA editing, and RNA methylation can affect gene expression.
Transcription Factor Family
- The E2F transcription factor family is mentioned in the text.
Lecture Topics
- Dr. Helen Knight's lecture in February 2020 focuses on breast cancer.
- Dr. Ho Wan Yong's lecture focuses on the genetic and epigenetic landscape of breast cancer.
Objectives and Risk Factors
- The 'Objectives' section requests an understanding of the genetic and epigenetic changes in breast cancer.
- Not listed as a risk factor for breast cancer is [factor not specified in the text].
- The strongest risk factor for breast cancer is [factor not specified in the text, but mentioned in the original text].
Global Cancer Statistics
- Breast cancer is the most prevalent cancer in the world.
- The region with the highest rates of breast cancer is [region not specified in the text, but mentioned in the original text].
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