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Questions and Answers
What is the primary goal of prevention in cancer?
What is the primary goal of prevention in cancer?
What is the role of molecular oncology in diagnosis?
What is the role of molecular oncology in diagnosis?
What is the effect of mutations in oncogenes on cell growth?
What is the effect of mutations in oncogenes on cell growth?
What is an example of a growth factor receptor oncogene?
What is an example of a growth factor receptor oncogene?
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What is the term for the protein encoded by an oncogene?
What is the term for the protein encoded by an oncogene?
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What was the focus of the TCGA study on head and neck squamous cell carcinomas?
What was the focus of the TCGA study on head and neck squamous cell carcinomas?
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What is the normal function of the gene product that is inactivated by mutations?
What is the normal function of the gene product that is inactivated by mutations?
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How many mutations are usually required to inactivate a tumor suppressor gene?
How many mutations are usually required to inactivate a tumor suppressor gene?
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What is the function of the tumor suppressor gene TP53?
What is the function of the tumor suppressor gene TP53?
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What is the result of DNA damage that is not repaired properly?
What is the result of DNA damage that is not repaired properly?
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What is the normal response of normal cells to internal or external signals?
What is the normal response of normal cells to internal or external signals?
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How do tumor cells resist cellular death?
How do tumor cells resist cellular death?
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What is the function of tumor suppressor genes such as BRCA1 and MLH1?
What is the function of tumor suppressor genes such as BRCA1 and MLH1?
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What is the result of the loss of tumor suppressor gene RB?
What is the result of the loss of tumor suppressor gene RB?
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What is the primary difference in energy metabolism between normal cells and cancer cells?
What is the primary difference in energy metabolism between normal cells and cancer cells?
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What is the purpose of using radiolabeled glucose in PET scans?
What is the purpose of using radiolabeled glucose in PET scans?
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What is the name of the phenomenon where cancer cells exhibit high glucose uptake and aerobic glycolysis?
What is the name of the phenomenon where cancer cells exhibit high glucose uptake and aerobic glycolysis?
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What is the energy yield of aerobic glycolysis in cancer cells?
What is the energy yield of aerobic glycolysis in cancer cells?
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What is the purpose of the Krebs cycle in normal cells?
What is the purpose of the Krebs cycle in normal cells?
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What is the difference in glucose metabolism between normal cells and stem cells?
What is the difference in glucose metabolism between normal cells and stem cells?
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What is the role of oncogenes in cancer cell proliferation?
What is the role of oncogenes in cancer cell proliferation?
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What is the significance of the Warburg effect in cancer metabolism?
What is the significance of the Warburg effect in cancer metabolism?
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What is the primary target of standard cytotoxic chemotherapy?
What is the primary target of standard cytotoxic chemotherapy?
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What is the advantage of molecularly targeted therapy compared to standard cytotoxic chemotherapy?
What is the advantage of molecularly targeted therapy compared to standard cytotoxic chemotherapy?
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What is the primary mechanism of action of cetuximab?
What is the primary mechanism of action of cetuximab?
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Which patient group may benefit more from EGFR-targeted therapy?
Which patient group may benefit more from EGFR-targeted therapy?
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What is the limitation of using EGFR-targeted therapy in HPV-positive HNSCC?
What is the limitation of using EGFR-targeted therapy in HPV-positive HNSCC?
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What is the primary reason why we don't all develop tumors?
What is the primary reason why we don't all develop tumors?
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What is the role of molecular knowledge in molecularly targeted therapy?
What is the role of molecular knowledge in molecularly targeted therapy?
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What is the primary advantage of consulting the NCCN guidelines?
What is the primary advantage of consulting the NCCN guidelines?
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What is the term used to describe the process by which a growing tumor induces its own blood supply?
What is the term used to describe the process by which a growing tumor induces its own blood supply?
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What is the consequence of mutations in tumor suppressor genes?
What is the consequence of mutations in tumor suppressor genes?
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What type of genes are responsible for regulating programmed cell death?
What type of genes are responsible for regulating programmed cell death?
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What is the term used to describe genetic mutations that affect cell cycle regulation and lead to neoplasia?
What is the term used to describe genetic mutations that affect cell cycle regulation and lead to neoplasia?
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What is the primary difference between proto-oncogenes and oncogenes?
What is the primary difference between proto-oncogenes and oncogenes?
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What is the term used to describe the process by which the immune system recognizes and clears abnormal cells?
What is the term used to describe the process by which the immune system recognizes and clears abnormal cells?
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What type of genetic lesions can lead to cancer?
What type of genetic lesions can lead to cancer?
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What is the term used to describe the 10 key characteristics of cancer cells?
What is the term used to describe the 10 key characteristics of cancer cells?
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Study Notes
Molecular Basis of Cancer
- Cancer arises from genetic lesions that affect cell cycle regulation, leading to increased cell proliferation and survival.
- The immune system clears most abnormal cells, but mutations can create "neo-epitopes" recognized by the immune system.
- Growing tumors must induce blood supply (angiogenesis) to exceed 1-2mm in size.
Risk Factors
- Exposure to radiation, chemicals/toxins/alcohol, and viruses
- Reproductive history, inflammation, immunodeficiency, hereditary, and age
- Geographic factors, including local differences, culture, and health disparities
Genetic Lesions
- Genetic damage can occur in DNA or epigenetic (DNA methylation or chromatin changes)
- Targets of genetic damage include growth regulatory genes, tumor suppressor genes, genes regulating programmed cell death, and DNA repair genes
Oncogenes and Proto-Oncogenes
- Oncogenes are genes that promote cell growth and proliferation when mutated
- Proto-oncogenes are normal genes that can become oncogenes when mutated
- Examples of oncogenes include PDGFB, PDGFBR, KRAS, MYC, and CDK4
Oncoproteins
- Oncoproteins are proteins encoded by oncogenes
- Mutations in oncogenes create constitutionally active versions of gene products that promote excessive cell growth
Tumor Suppressor Genes
- Mutations in tumor suppressor genes inactivate gene products that normally stop excessive cell growth
- Examples of tumor suppressor genes include p16, RB, TP53, CDH1, BRCA1, and MLH1
- Loss of tumor suppressor RB can lead to retinoblastoma
Cellular Alterations
- 10 hallmarks of cancer include:
- Self-sufficiency in growth signals
- Insensitivity to anti-growth signals
- Tissue invasion and metastasis
- Limitless replicative potential
- Evading apoptosis
- Sustained angiogenesis
- Tissue inflammation
- Evading immune surveillance
- Deregulating cellular energetics
- Genomic instability and mutation
Cancer Treatment
- Molecularly targeted therapy can be more effective than standard cytotoxic chemotherapy
- Examples of targeted therapy include EGFR inhibitors like cetuximab
- NCCN guidelines provide guidance on therapy for head and neck cancers
Head and Neck Cancer
- TCGA study sequencing of head and neck squamous cell carcinomas identified potential oncogenes
- EGFR is often overexpressed in head and neck cancer
- HPV-negative patients may benefit from EGFR-targeted therapy
Cellular Death
- Tumor cells resist cellular death by mutations in the programmed cell death signaling pathway
- Normal cells respond to internal or external signals for programmed cell death
Cellular Energetics
- Cancer cells use aerobic glycolysis (Warburg effect) to generate energy for rapid growth
- PET scans use radiolabeled glucose to track tumor metastases
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Description
Learn about the differences between proto-oncogenes and oncogenes, oncoproteins, and the 10 hallmarks of cancer. Understand the risk factors and epidemiology of cancer.