MOL GEN Epigenetic 3: Heterochromatin Formation and X-Chromosome Inactivation

Dosage compensation is necessary to balance the amount of gene expression between males and females. Is this statement true or false?

In mammals, one of the X chromosomes in females is inactivated through heterochromatin formation. Is this process known as constitutive heterochromatin or facultative heterochromatin?

In flies (Drosophila), is the expression of X-linked genes two times higher in males than in females? True or false?

In C.Elegans, in females, there is half the expression of X-linked genes compared to males. Is this statement true or false?

Constitutive heterochromatin includes permanently unexpressed sequences such as Satellite DNA in the centromeric region or telomeric region with these telomeric repeats. Is this statement true or false?

Heterochromatin organization is related to gene expression regulation. Is this statement true or false?

Facultative heterochromatin refers to the presence of inactive genes in certain sequences.

X chromosome inactivation occurs randomly during the first developmental stages.

All X chromosomes are active at the beginning of embryonic development.

There is no gene escape from X inactivation.

The X inactivation center involves long noncoding RNA.

The Xist gene in the inactivation center is transcribed into RNA.

The t6 RNA binds to the X inactivation center and stabilizes it.

The binding of the Xist gene to its own locus leads to the recruitment of heterochromatin proteins.

The presence of t6 RNA leads to activation of the X state.

X chromosome inactivation is a good example of RNA's involvement in chromatin structure.