Skin therapeutics

<p>The potential for ototoxicity if the tympanic membrane is ruptured</p> Signup and view all the answers

<p>Maximum 1-2 times weekly</p> Signup and view all the answers

<p>Possible toxicity or loss of efficacy if licked off</p> Signup and view all the answers

<p>Resistance to antibiotics</p> Signup and view all the answers

<p>Fluoroquinolone products</p> Signup and view all the answers

<p>Hydrocortisone</p> Signup and view all the answers

<p>Polymixin-B</p> Signup and view all the answers

<p>Pus</p> Signup and view all the answers

<p>Limited access to skin due to hair</p> Signup and view all the answers

<p>Improve skin barrier function</p> Signup and view all the answers

<p>Actions of the drugs</p> Signup and view all the answers

<p>Squalene</p> Signup and view all the answers

<p>Increased risk of infection</p> Signup and view all the answers

<p>They reduce transepidermal water loss</p> Signup and view all the answers

<p>Colloidal oatmeal</p> Signup and view all the answers

<p>To increase water content of the stratum corneum</p> Signup and view all the answers

<p>Essential fatty acids</p> Signup and view all the answers

<p>To reduce cohesion between cells of the stratum corneum</p> Signup and view all the answers

<p>Sulphur</p> Signup and view all the answers

<p>Whether the coat is greasy or dry</p> Signup and view all the answers

<p>Antibiotic, antifungal, and corticosteroid</p> Signup and view all the answers

<p>To treat secondary infection</p> Signup and view all the answers

<p>They can cause maceration of the ear canal</p> Signup and view all the answers

<p>The lowest potency glucocorticoid possible is hydrocortisone.</p> Signup and view all the answers

<p>Gentamycin and polymixin-B are more ototoxic than others.</p> Signup and view all the answers

<p>Polymixin-B is inactivated by pus.</p> Signup and view all the answers

<p>Ear cleaners should be used a maximum of 1-2 times weekly to avoid maceration of the ear canal.</p> Signup and view all the answers

<p>The common aims of therapy for otitis externa are to kill/repel parasites, control/cure microbial infection, control inflammation/pruritus, moisturize/improve skin barrier function, and resolve scale.</p> Signup and view all the answers

<p>The pros of using topical therapy include decreased concerns about side effects associated with systemic drugs, direct delivery of drug to skin which can achieve higher concentration than with systemic therapy, and the ability to target therapy and achieve differing actions on different areas.</p> Signup and view all the answers

<p>The cons of using topical therapy include being labor-intensive with compliance being an issue, some animals may not tolerate it, the area of the body may preclude its use, hair may impede access to the skin, and there is a possible toxicity/loss of efficacy if licked off.</p> Signup and view all the answers

<p>Emollients are substances that soften, lubricate, and soothe the skin. They help to seal in water and reduce water loss from the stratum corneum. They can be derived from animal or plant-based oils, such as lanolin, coconut oil, or vaseline.</p> Signup and view all the answers

<p>Moisturisers increase the water content of the stratum corneum by drawing in water. They contain ingredients such as colloidal oatmeal, aloe vera, urea, glycerine, propylene glycol, sodium or ammonium lactate/lactic acid.</p> Signup and view all the answers

<p>Some agents that can improve skin barrier function include essential fatty acids (taken orally or applied topically), some essential oils, and ophytrium.</p> Signup and view all the answers

<p>Antiseborrhoeic agents used to control scale have keratolytic and keratoplastic properties. Keratolytic agents reduce the cohesion between cells of the stratum corneum, while keratoplastic agents restore normal epidermal epithelialisation and keratinisation and reduce epithelial turnover. Common keratoplastic/keratolytic agents include sulphur, salicylic acid, and ammonium lactate.</p> Signup and view all the answers

<p>Drying drugs like chlorhexidine should be used with caution as they can have a drying effect on the skin. They may need to be formulated with a moisturiser to minimize drying, and regularity of application should be considered.</p> Signup and view all the answers

<p>Polypharmacy ear drops/creams used to treat otitis externa typically contain an antibiotic, an antifungal, and a corticosteroid. These components are used to treat the inflammation and secondary infection often associated with otitis externa.</p> Signup and view all the answers

<p>The selection of a product for otitis externa treatment is based on various factors. These include the severity of inflammation and infection, the presence of pus, the greasiness or dryness of the coat, and the desired outcome of the therapy.</p> Signup and view all the answers