Module 3: Tests for Intended Parents

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Questions and Answers

What is the primary purpose of the psychological evaluation for intended parents?

To evaluate the mental and emotional readiness for surrogacy (correct)

To determine the financial stability of the intended parents

To assess physical health conditions

To test for infectious diseases

Which of the following tests is included in medical screening for intended parents?

HIV testing

Chlamydia screening

DNA fragmentation checks (correct)

Psychological assessments

What is the importance of infectious disease testing in the context of surrogacy?

To evaluate the emotional readiness of intended parents

To screen for conditions affecting the surrogate and child (correct)

To determine the legal implications of surrogacy

To ensure the financial stability of the surrogate

What might poor sperm quality indicate during medical screening?

Potential challenges in the surrogacy journey Signup and view all the answers

Why is it important to assess the ovarian reserve of female partners in the medical screening process?

To determine reproductive potential Signup and view all the answers

What is the consequence of not conducting a psychological evaluation for intended parents?

Ignoring potential psychological challenges Signup and view all the answers

Which of the following diseases is NOT part of the infectious disease testing for intended parents?

Diabetes Signup and view all the answers

How does medical screening directly impact the surrogacy process?

By identifying health issues that may affect success Signup and view all the answers

What is one of the main issues associated with a high percentage of sperm showing DNA fragmentation?

Poor embryo development Signup and view all the answers

What does a normal Karyotype indicate in males?

46XY Signup and view all the answers

What is the probability of having a child with a genetic disease if both parents are carriers of the same mutation?

25% Signup and view all the answers

Which genetic conditions can be analyzed using Next-Generation Sequencing (NGS) in Carrier Genetic Testing?

Cystic Fibrosis and Spinal Muscular Atrophy Signup and view all the answers

What action is required from intended parents (IPs) before conducting Carrier Genetic Testing?

Join a WhatsApp group with a genetic lab representative Signup and view all the answers

What happens after the sample for Carrier Genetic Testing is received at the laboratory?

The report is released in 35-45 days. Signup and view all the answers

If an intended parent refuses Carrier Genetic Testing after counseling, what must they do?

Inform the team via email. Signup and view all the answers

What additional screening is needed if a genetic carrier mutation is found in the intended father?

The egg donor must be tested for the same mutation. Signup and view all the answers

What is one benefit of using the Igenomix genetic lab for Carrier Genetic Testing?

All egg donors are tested there, allowing for better comparative analysis. Signup and view all the answers

If the chosen egg donor is found to be a carrier of the same genetic mutation, who bears the cost of testing a second donor?

The intended parents are responsible for the additional costs. Signup and view all the answers

What is the main purpose of Carrier Genetic Testing (CGT) in the context of surrogacy?

To identify potential genetic disorders that may be passed to the child Signup and view all the answers

Which of the following tests is highly recommended but not mandatory for intended parents?

Carrier Genetic Testing (CGT) Signup and view all the answers

What does a semen analysis NOT evaluate?

Sperm DNA fragmentation rate Signup and view all the answers

Why is it important to conduct legal and background checks for intended parents in surrogacy?

To ensure compliance with legal regulations Signup and view all the answers

Which panel of CGT tests is the most comprehensive and assesses the highest number of genes?

CGT Exome Signup and view all the answers

What minimum sperm concentration is considered normal in a semen analysis?

15 million per milliliter Signup and view all the answers

What is the significance of sperm DNA fragmentation in infertility assessments?

It measures the structural integrity of sperm DNA. Signup and view all the answers

Which of the following infections is NOT included in the screening for intended parents?

Tuberculosis Signup and view all the answers

What does karyotype analysis assess in intended parents?

Presence of genetic disorders or abnormalities Signup and view all the answers

Which hormone is NOT typically monitored in female fertility tests?

Progesterone Signup and view all the answers

What is the recommended abstinence period before a sperm collection for analysis?

3 days Signup and view all the answers

Why are infection screenings conducted for intended parents?

To prevent transmission of infectious diseases to the child Signup and view all the answers

What is the normal range for sperm motility according to semen analysis parameters?

40% to 81% Signup and view all the answers

What is one significant role of conducting initially required tests in surrogacy?

They help assess the readiness and health of intended parents. Signup and view all the answers

Study Notes

Psychological Evaluation

Evaluates mental and emotional readiness of intended parents for the surrogacy process.
Identifies psychological challenges potentially impacting the surrogacy journey.
Ensures parents are equipped to handle emotional complexities.

Medical Screening

Involves sperm tests for males and ovarian reserve check-ups for females.
Assesses reproductive health to guide the surrogacy process effectively.
Identifies health issues that may affect the surrogate or child's well-being.

Infectious Disease Testing

Screens for Hepatitis B, Hepatitis C, HIV, Syphilis, Chlamydia, Gonorrhea, and other infections.
Aims to prevent communicable disease transmission during surrogacy.
Protects the health of the surrogate and child while ensuring legal compliance.

Genetic Testing

Includes Carrier Genetic Testing (CGT) and karyotype analysis.
Evaluates genetic compatibility and risks for intended parents.
Aims to prevent genetic disorders and supports informed decision-making.

Legal and Background Checks

Confirms legal status and eligibility of intended parents for surrogacy.
Protects rights and interests of all participants in the surrogacy arrangement.
Ensures compliance with legal regulations governing surrogacy.

Sperm Lab Analysis

Evaluates sperm concentration, motility, morphology, and DNA fragmentation.
Helps identify potential fertility problems based on structured sperm analysis.
Normal sperm parameters include pH 7.2-8.0, volume 1.5-7.6 ml, and motility 40-81%.

DNA Fragmentation

Refers to changes or breaks in sperm DNA, impacting fertility and embryo development.
High DNA fragmentation correlates with poor implantation and increased miscarriage rates.

Karyotype Analysis

Provides a visual representation of an individual’s chromosomes.
Identifies chromosomal abnormalities and genetic disorders.
Normal karyotypes for males and females are noted as 46XY and 46XX, respectively.

Carrier Genetic Testing (CGT)

Determines risk of genetic diseases in offspring by identifying recessive gene carriers.
Utilizes Next-Generation Sequencing (NGS) for a comprehensive panel analysis.
Essential for ensuring compatibility between intended parents and egg donors.

Recommended CGT Panels

Essential (24 genes), Plus (579 genes), and Exome (2200 genes) with varying prices.
Plus or Exome programs highly recommended for thorough lifetime genetic reports.

Testing Process and Responsibilities

Organize sample collection with an Igenomix representative and send a saliva kit.
Return sample to the lab, with results typically available in 35-45 days.
Results influence additional testing for selected egg donors if required.

Documentation and Communication

Coordinators manage collection and storage of all required tests and documents.
Clear communication channels must be established, including WhatsApp for assistance and documentation sharing.
Patients have the right to decline tests, but must document their decision formally.

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Description

Explore the essential initial tests required for intended parents in the surrogacy process. This quiz emphasizes the importance of psychological evaluations and how they help assess the readiness of parents to handle the emotional challenges of surrogacy.