5 Questions
What is the function of Drosha in miRNA biogenesis?
Drosha cleaves the base of the hairpin structure to form pre-miRNA.
Describe the process by which the mature miRNA is released from the pre-miRNA molecule.
The Dicer enzyme cuts 20-25 nucleotides from the base of the hairpin to release the mature miRNA.
Where does the annealing of miRNA to mRNA usually occur?
The annealing of the miRNA to the mRNA usually occurs at a site in the 3’-UTR (untranslated region) of the mRNA.
What is the function of miRNAs in gene regulation?
The function of miRNAs appears to be in gene regulation by inhibiting protein translation through annealing with mRNA or triggering mRNA degradation.
How does the formation of double-stranded RNA through the binding of miRNA affect mRNA transcript?
In some cases, it triggers the degradation of the mRNA transcript through a process similar to RNAi, and in other cases, it blocks the protein translation machinery without causing mRNA degradation.
Test your knowledge of miRNA biogenesis and the formation of pri-miRNA and pre-miRNA with this quiz. Explore the process of how miRNA sequences form a double-stranded RNA hairpin loop and are cleaved by Drosha to generate pre-miRNA.
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