Pharm: Antibacterial introduction

What is the minimum inhibitory concentration?

What is the MBC?

The MIC and the zone diameter of inhibition are _________ correlated

What is the effect of a bactericidal?

What does a large MBC/MIC ratio indicate for a bacteriostatic drug?

When are bactericidal antibiotics indicated over bacteriostatic antibiotics?

What does a low MBC/MIC ratio indicate for bactericidal drugs?

Why do bacteriostatic antibiotics with a large MBC/MIC ratio require a functional immune system?

Why should bactericidal and bacteriostatic drugs generally NOT be given together?

What happens to bacterial killing rates when bactericidal and bacteriostatic drugs are combined?

How do time-dependent antibiotics achieve their effect?

What percentage of the dosing interval should a time-dependent drug remain above the MIC for optimal efficacy?

Why does increasing the concentration of a time-dependent drug beyond the MIC NOT significantly improve efficacy?

Which of the following is true about time-dependent antibiotics?

What is the primary factor that determines the efficacy of concentration-dependent antibiotics?

Why is it NOT beneficial to maintain a high concentration of a concentration-dependent drug for prolonged periods?

How does the mechanism of concentration-dependent drugs differ from time-dependent drugs?

What is a common feature of concentration-dependent antibiotics?

What is the post-antibiotic effect (PAE)?

Why do drugs with long post-antibiotic effects (PAE) need to be dosed less frequently?

Which of the following is true about antibiotics with short PAE?

What are the common routes of administration?

What is the most common side effect of antibiotics in general?

List the bactericidals that are concentration dependent

List the antibiotics that have a long post antibiotic effect

List the antibiotics with an intermediate postantibiotic effect

Which of the following antibiotic(s) have a long postantibiotic effect and an intermediate effect?

Which of the following antibiotic(s) has an intermediate postantibiotic effect and a short post antibiotic effect?

Which of the following bactericidals are time dependent?

Glycopeptides are a bactericidal that are time dependent

What antibiotics with a bacteriostatic effect are time dependent?

Match the antibiotic to its effect

Aminoglycosides have a _______________ (bactericidal/bacteriostatic) effect

Diaminopyrimidines have a ___________________ (bactericidal/bacteriostatic) effect

In general, folic acid synthesis inhibitors have a bactericidal effect

The antibiotic rifampin , can have both bactericidal and bacteriostatic effects

Metronidazole has a __________________ (bactericidal/bacteriostatic) effect

Tetracyclines inhibit protein synthesis

Aminoglycosides impair proofreading, resulting in production of faulty proteins