Pharm I: Infectious Diseases

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Questions and Answers

Which of the following is NOT a characteristic of Empiric therapy?

  • Antibiotic selection based on knowledge of typical pathogens
  • May involve combination therapy to target most common pathogens
  • Therapy started before culture results are available
  • Always involves monotherapy with a narrow-spectrum antibiotic (correct)

Which bacterial genus is a Gram-positive cocci and is commonly associated with skin infections?

  • Clostridium
  • Corynebacterium
  • Streptococcus
  • Staphylococcus (correct)

Which bacterial genus is a Gram-positive rod that is commonly associated with food poisoning and can be a serious concern for pregnant women?

  • Corynebacterium
  • Listeria (correct)
  • Clostridium
  • Enterococcus

Which of the following is NOT a characteristic of Definitive therapy?

<p>Always involves combination therapy with broad-spectrum antibiotics (A)</p> Signup and view all the answers

Which of the following statements accurately describes the differences between Gram stain and bacterial culture?

<p>Bacterial culture is more time-consuming, but provides definitive identification of the organism while Gram stain only indicates the presence of bacteria (D)</p> Signup and view all the answers

Which of the following is an atypical bacteria that is NOT a spirochete?

<p>Mycoplasma (B), Legionella (C), Mycobacterium (D)</p> Signup and view all the answers

Which of the following statements is TRUE about the use of antibiotics?

<p>The overuse and misuse of antibiotics can contribute to the development of antibiotic resistance. (D)</p> Signup and view all the answers

What makes the treatment of fungal infections challenging?

<p>All of the above. (D)</p> Signup and view all the answers

Why are many antifungal drugs designed to slow the growth of the fungus rather than killing it?

<p>Slowing growth allows the host's immune system to effectively combat the infection. (B)</p> Signup and view all the answers

Which of the following is NOT an opportunistic fungal infection?

<p>Histoplasmosis (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of ergosterol?

<p>It is essential for the synthesis of DNA and RNA in fungi. (D)</p> Signup and view all the answers

Which of the following bacterial species is typically associated with urinary tract infections (UTIs)?

<p>Escherichia coli (A)</p> Signup and view all the answers

Which of the following is a commensal fungal species that is part of the normal flora of humans?

<p>Candida albicans (C)</p> Signup and view all the answers

Which of the following antibiotics is most likely to be bactericidal?

<p>Vancomycin (C)</p> Signup and view all the answers

Which of the following antibiotic classes is known to be effective against a broad spectrum of bacteria, including Gram-positive, Gram-negative, and atypical organisms?

<p>Fluoroquinolones (D)</p> Signup and view all the answers

Which of the following statements is TRUE about bacteriostatic antibiotics?

<p>They prevent bacterial growth but do not eliminate existing bacteria. (A)</p> Signup and view all the answers

Which one of these bacterial species is known to be a nitrite reducer?

<p>Salmonella enterica (B)</p> Signup and view all the answers

Which of the following antibiotics is a narrow-spectrum antibiotic?

<p>Cefazolin (D)</p> Signup and view all the answers

Which of the following bacterial species is considered a non-fermenter?

<p>Pseudomonas aeruginosa (D)</p> Signup and view all the answers

Which of the following statements best describes a patient who should NOT receive a bacteriostatic antibiotic?

<p>A patient with a severe infection and compromised immune system. (C)</p> Signup and view all the answers

Which of the following is NOT a key principle of effective antibiotic use?

<p>Determining the patient's blood type for compatibility. (B)</p> Signup and view all the answers

Which of the following antibiotic classes primarily targets bacterial protein synthesis?

<p>Aminoglycosides (D)</p> Signup and view all the answers

Which of the following mechanisms of antibiotic resistance involves the alteration of the target site?

<p>MRSA's alteration of the beta-lactam binding protein (D)</p> Signup and view all the answers

Which of the following antibiotic classes is commonly affected by reduced permeability in gram-negative bacteria?

<p>Fluoroquinolones (D)</p> Signup and view all the answers

Which of the following mechanisms of antibiotic resistance is commonly associated with multidrug resistance (MDR) efflux pumps?

<p>Efflux pump activity (C)</p> Signup and view all the answers

Which of the following antibiotic classes is specifically mentioned as being resistant in cases of Rifampin resistance due to alterations in the binding site?

<p>Rifampin (C)</p> Signup and view all the answers

Which of the following is NOT a mechanism of antibiotic resistance discussed in the provided text?

<p>Increased bacterial cell division rate (A)</p> Signup and view all the answers

Which of the following is a crucial step in the systematic approach to selection of antimicrobial agents?

<p>Identification of the causative pathogen (C)</p> Signup and view all the answers

Which of the following is NOT a common approach to guiding empiric antibiotic therapy?

<p>Direct microscopic examination of the patient's blood (A)</p> Signup and view all the answers

Which of the following is a critical aspect of monitoring therapeutic response in patients receiving antimicrobial treatment?

<p>Monitoring for signs of potential antibiotic resistance (D)</p> Signup and view all the answers

Which of the following mechanisms of antibiotic resistance is particularly common in gram-negative bacteria, especially Pseudomonas, and often affects beta-lactams, fluoroquinolones, and aminoglycosides?

<p>Reduced permeability (B)</p> Signup and view all the answers

Which of the following is NOT a consequence of Reverse Transcriptase's error-prone nature?

<p>Increased efficiency of viral protein synthesis (C)</p> Signup and view all the answers

What is the primary target of Antiretroviral Therapy (ART) in HIV patients?

<p>Reverse Transcriptase (D)</p> Signup and view all the answers

Which of the following statements accurately describes the function of Integrase?

<p>Integrase integrates HIV DNA into the host cell's chromosome (A)</p> Signup and view all the answers

What is the primary reason why HIV cannot be cured with current treatments?

<p>The integration of HIV DNA into the host cell's genome (C)</p> Signup and view all the answers

What is the main reason why continuous ART is necessary for managing HIV?

<p>To control viral load and prevent transmission (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic of a retrovirus?

<p>Replication through a DNA intermediate (A)</p> Signup and view all the answers

Which of the following is NOT a consequence of HIV's rapid mutation rate?

<p>Inability to integrate viral DNA into the host genome (B)</p> Signup and view all the answers

Which of the following best describes the goal of achieving undetectable levels of HIV-RNA in patients undergoing ART?

<p>Suppressing HIV replication to a point where it cannot harm the immune system (D)</p> Signup and view all the answers

Why is it important to suppress HIV replication to maximal levels in patients receiving ART?

<p>To minimize the risk of transmission to others (C)</p> Signup and view all the answers

Which enzyme is NOT unique to retroviruses?

<p>DNA Polymerase (C)</p> Signup and view all the answers

Which type of shock is characterized by a loss of vascular tone leading to vasodilation and hypoperfusion, despite a normal cardiac output?

<p>Distributive/Vasodilatory Shock (D)</p> Signup and view all the answers

Which of the following statements accurately describes the pathophysiology of Septic Shock?

<p>Uncontrolled systemic inflammation triggered by infection causes vasodilation and increased capillary permeability, leading to tissue hypoperfusion despite normal cardiac output. (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of Septic Shock?

<p>Reduced cardiac output due to decreased contractility of the heart muscle (A)</p> Signup and view all the answers

Which of the following is a key component of treatment for Sepsis?

<p>Early recognition of the condition and initiation of appropriate interventions (B)</p> Signup and view all the answers

What is the primary reason for the use of vasopressors in the treatment of Septic Shock?

<p>To constrict blood vessels and increase blood pressure, restoring adequate tissue perfusion (B)</p> Signup and view all the answers

Which of the following is a hallmark of a patient with Septic Shock who is receiving appropriate care?

<p>Sustained improvement in blood pressure and tissue perfusion with adequate fluid resuscitation and vasopressor support (D)</p> Signup and view all the answers

Which of the following is NOT a typical sign of tissue hypoperfusion in a patient with shock?

<p>Increased urine output (D)</p> Signup and view all the answers

What is the primary cause of the decreased venous return seen in Hypovolemic Shock?

<p>Loss of fluid volume due to hemorrhage or dehydration (C)</p> Signup and view all the answers

Which of the following BEST summarizes the concept of 'The Tank is Empty' in the context of Hypovolemic Shock?

<p>There is a lack of adequate fluid volume in the circulatory system, creating a shortage of blood to pump. (B)</p> Signup and view all the answers

Which of the following antibiotic classes is primarily known for its bactericidal activity against a wide range of bacteria, including Gram-positive, Gram-negative, and atypical organisms?

<p>Fluoroquinolones (A)</p> Signup and view all the answers

Which of the following scenarios would be LEAST appropriate for the use of a bacteriostatic antibiotic?

<p>A patient with a compromised immune system suffering from a serious bacterial infection. (C)</p> Signup and view all the answers

Which of the following groups of bacteria are commonly associated with urinary tract infections (UTIs) and are known as nitrite producers?

<p>coli, Proteus, Klebsiella (C)</p> Signup and view all the answers

Which of the following antibiotic classes is known to be effective against a broad spectrum of bacteria, including Gram-positive, Gram-negative, and atypical organisms, making them useful for empiric therapy?

<p>Fluoroquinolones (D)</p> Signup and view all the answers

What type of patient should not receive a bacteriostatic antibiotic?

<p>A patient recovering from surgery with a compromised immune system (C)</p> Signup and view all the answers

Which of the following best describes a non-fermenter bacteria, such as Pseudomonas, as it relates to its metabolic characteristics?

<p>They lack the ability to use glucose as an energy source. (A)</p> Signup and view all the answers

Which of the following statements accurately describes a key principle of effective antibiotic use?

<p>Understanding the causative organism and its susceptibility to the chosen antibiotic is crucial for effective treatment. (D)</p> Signup and view all the answers

What is the primary mechanism of action for Nucleotide Reverse Transcriptase Inhibitors (NRTIs)?

<p>Terminate DNA elongation by binding to Reverse Transcriptase (B)</p> Signup and view all the answers

Which class of antiretroviral drugs is particularly associated with increased risk of developing a rash that may lead to serious conditions like DRESS or SJS?

<p>Non-nucleotide Reverse Transcriptase Inhibitors (D)</p> Signup and view all the answers

For patients with a CD4 count less than 200, what is the recommended first-line prophylactic therapy against Pneumocystis jirovecii pneumonia (PCP)?

<p>Trimethoprim-sulfamethoxazole (Bactrim) (C)</p> Signup and view all the answers

What is a common consequence when using Integrase Strand Transfer Inhibitors (InSTIs) and antacids together?

<p>Decreased bioavailability of InSTIs (B)</p> Signup and view all the answers

What is a major limitation in the use of non-nucleotide reverse transcriptase inhibitors (NNRTIs) in HIV treatment?

<p>High incidence of resistance development with any mutation that changes binding site (C)</p> Signup and view all the answers

What is a crucial safety concern associated with the use of Ganciclovir and Valganciclovir?

<p>Myelosuppression and potential for infertility (A)</p> Signup and view all the answers

Which of the following statements about Acyclovir is incorrect?

<p>It becomes active outside cells infected with herpes virus. (D)</p> Signup and view all the answers

What is the primary mechanism by which Remdesivir acts against viral infections?

<p>Inhibiting RNA polymerase (B)</p> Signup and view all the answers

For which patient population is Daily Suppressive Therapy for HSV most recommended?

<p>Patients with frequent HSV outbreaks (C)</p> Signup and view all the answers

Which class of antiviral drugs is primarily used to treat Cytomegalovirus infections?

<p>Nucleoside Analogues (C)</p> Signup and view all the answers

What is a common adverse effect of Remdesivir that requires monitoring during treatment?

<p>Elevated liver function tests (A)</p> Signup and view all the answers

What distinguishes Valacyclovir from Acyclovir?

<p>Valacyclovir is a prodrug with better oral bioavailability (D)</p> Signup and view all the answers

Which of the following is NOT a recommended treatment for COVID-19?

<p>Probenecid (C)</p> Signup and view all the answers

Why are Adamantanes not recommended for treating influenza?

<p>They only work against Influenza A H1N1, which is now predominantly resistant. (D)</p> Signup and view all the answers

What is the primary role of Reverse Transcriptase in the lifecycle of a retrovirus?

<p>To convert RNA into DNA (A)</p> Signup and view all the answers

What consequence does the poor fidelity of Reverse Transcriptase have on HIV?

<p>It contributes to rapid mutation and drug resistance (A)</p> Signup and view all the answers

What is the role of Integrase in HIV infection?

<p>To integrate viral DNA into the host cell's genome (C)</p> Signup and view all the answers

Why is ART (Antiretroviral Therapy) required to be taken continuously?

<p>Because of the persistent latent infection established by Integrase (D)</p> Signup and view all the answers

What are the primary goals of ART in HIV patients?

<p>Restore immune function and prevent transmission (A)</p> Signup and view all the answers

What challenge arises from the integration of HIV DNA into the host’s chromosome?

<p>It creates a reservoir for latent infection (D)</p> Signup and view all the answers

In what way does the retrovirus lifecycle differ from typical viral replication?

<p>It uses RNA as a template to synthesize DNA (A)</p> Signup and view all the answers

What is primarily targeted by ART to reduce HIV replication?

<p>Reverse Transcriptase enzyme (A)</p> Signup and view all the answers

What makes developing a vaccine against HIV particularly complicated?

<p>The high mutation rate due to Reverse Transcriptase errors (A)</p> Signup and view all the answers

What percentage of people with HIV are estimated to be unaware of their infection?

<p>13% (A)</p> Signup and view all the answers

Flashcards

Pathogenic Fungi

Fungi that can cause diseases in healthy individuals.

Candidiasis

A common fungal infection caused by Candida species.

Opportunistic Fungi

Fungi that infect those with weakened immune systems.

Ergosterol

A sterol component of fungal cell membranes, similar to cholesterol.

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Challenges in Treating Fungal Infections

Fungal infections are hard to treat due to slow growth and immune dependence.

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Bactericidal

Antibiotics that kill bacteria and can eradicate them even if the immune system is weak.

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Bacteriostatic

Antibiotics that inhibit bacterial growth but require an effective immune system to eliminate bacteria.

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Broad Spectrum Antibiotics

Antibiotics that cover a wide range of bacteria, including gram-positive and gram-negative strains.

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Narrow Spectrum Antibiotics

Antibiotics that target fewer organisms, preferred when the specific causative agent is known.

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Nitrite Producers

Bacteria that can convert nitrate to nitrite, commonly associated with UTIs.

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Antibiotic Resistance

The ability of bacteria to withstand the effects of antibiotics that once killed them or inhibited their growth.

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Gram-negative bacteria

Bacteria characterized by a thin peptidoglycan layer and an outer membrane, often resistant to antibiotics.

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PCN and Cephalosporins

Types of beta-lactam antibiotics that are very effective and bactericidal.

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Effective Antibiotic Use

Key considerations include identifying the organism, drug efficacy, and potential harm to the patient.

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Retrovirus

A type of virus that uses RNA to create DNA, then replicates.

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Reverse Transcriptase

An enzyme that converts RNA into DNA in retroviruses, crucial for replication.

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HIV Mutation

HIV's rapid changes due to errors in Reverse Transcriptase during replication.

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Integrase

An enzyme that integrates viral DNA into the host cell's chromosomes.

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Antiretroviral Therapy (ART)

A medication regimen aimed at reducing HIV replication and preserving immune function.

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Maximal Suppression

The goal to lower HIV-RNA levels to undetectable levels through ART.

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Immune Function Restoration

The process of restoring a person's immune response affected by HIV.

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Latent Infection

A persistent but inactive infection where the virus hides in cells.

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Drug Resistance in HIV

When HIV becomes less susceptible to medications due to mutations.

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Undetectable HIV Levels

When the amount of HIV-RNA in a person's blood is so low it cannot be detected.

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Antibiotic

A medication used to treat bacterial infections by killing or inhibiting their growth.

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Cell Wall Synthesis Inhibitors

Antibiotics that disrupt the formation of bacterial cell walls.

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Beta-Lactams

A class of antibiotics including Penicillin, Cephalosporins, and Carbapenems that contain a beta-lactam ring.

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Antibiotic Resistance Mechanisms

Processes bacteria use to survive exposure to antibiotics, such as enzymatic inactivation and efflux pumps.

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MRSA

Methicillin-resistant Staphylococcus aureus, a type of bacteria resistant to many antibiotics.

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Efflux Pumps

Protein systems in bacteria that expel antibiotics out of the cell, contributing to resistance.

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Biofilms

Communities of bacteria that cling to surfaces and are encased in a protective matrix, often increasing resistance.

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Aminoglycosides

A class of antibiotics that inhibit bacterial protein synthesis, effective against aerobic gram-negative bacteria.

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Sepsis

A life-threatening condition caused by the body's response to an infection, leading to tissue damage and organ failure.

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Pseudomonas

A genus of bacteria often resistant to multiple antibiotics and known to cause opportunistic infections.

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Empiric Therapy

Treatment started before knowing the causative agent.

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Definitive Therapy

Tailored therapy based on culture and sensitivity results.

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Gram Stain

A quick test indicating possible bacterial infections.

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Gram Positive Bacteria

Bacteria with a thick cell wall; stain purple in Gram stain.

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Combination Therapy

Using multiple antibiotics to treat infections.

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Bactericidal vs. Bacteriostatic

Bactericidal kills bacteria, while bacteriostatic inhibits growth.

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When to use Bactericidal

Bactericidal antibiotics are preferred for immunocompromised patients.

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When to use Bacteriostatic

Bacteriostatic antibiotics require a competent immune system to eliminate bacteria.

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Key considerations for Antibiotic Use

Identify organism, drug efficacy, patient safety, and drug delivery.

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Cell Wall & DNA Synthesis Inhibitors

Drugs that interrupt cell wall or DNA synthesis are typically bactericidal.

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Shock

Life threatening organ dysfunction caused by a dysregulated host response to infection leading to inflammation.

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Signs of Tissue Hypoperfusion

Symptoms indicating inadequate blood flow, including hypotension, elevated lactate, oliguria, and elevated liver enzymes.

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Hypovolemic Shock

Shock due to fluid loss, causing inadequate venous return and low cardiac output.

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Cardiogenic Shock

Shock caused by decreased cardiac function, leading to low cardiac output.

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Obstructive Shock

Shock caused by extracardiac obstruction of blood flow, leading to low cardiac output.

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Distributive Shock

Shock due to loss of vascular tone, causing vasodilation and hypoperfusion despite normal cardiac output.

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Septic Shock

Persistent hypotension requiring vasopressors in a patient with sepsis, despite fluid resuscitation.

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Treatment of Sepsis

Includes early recognition, fluid resuscitation, and culturing for infections.

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HIV-RNA Levels

Indicates the amount of HIV replication in the body.

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NRTIs

Nucleotide Reverse Transcriptase Inhibitors that block HIV DNA synthesis.

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Opportunistic Infections (OI)

Infections that occur more frequently in individuals with weakened immune systems, often related to CD4 counts.

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Bactrim

The treatment of choice for Pneumocystis jirovecii pneumonia, prevents and treats certain infections.

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HIV Treatment Challenges

The difficulties in creating a cure for HIV due to its rapid mutation and latent infection.

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Reverse Transcriptase Mutations

Mistakes made by Reverse Transcriptase during RNA to DNA conversion, leading to HIV mutations.

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Integrase Function

Enzyme that integrates viral DNA into the host's chromosomes, leading to persistent infection.

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Continuous ART Importance

Antiretroviral Therapy must be taken continuously to prevent HIV from reactivating.

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HIV RNA Levels Goal

The target of ART is to reduce HIV-RNA levels to undetectable.

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Effects of HIV Mutation

Allow HIV to evade immune responses and develop drug resistance.

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Role of RNA-Dependent DNA Polymerase

Enzyme necessary for retroviruses to convert RNA into DNA, targeted by ART.

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Latent HIV Infection

A state where HIV hides in the host cells, making it difficult to eradicate.

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Antiretroviral Therapy Goals

To restore immune function and prevent transmission of HIV.

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HIV Evading Immune Response

HIV's ability to change rapidly prevents the immune system from effectively targeting it.

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Acyclovir

Protype antiviral for herpes viruses, inhibits viral DNA synthesis.

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Valacyclovir

Prodrug of Acyclovir with improved oral bioavailability and less frequent dosing.

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Ganciclovir

Antiviral effective against herpes viruses, especially CMV, administered IV.

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CMV

Cytomegalovirus, a herpes virus causing disease in immunocompromised patients.

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Remdesivir

Antiviral developed for RNA viruses; inhibits viral RNA synthesis for COVID-19.

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Paxlovid

Combination antiviral for COVID-19; includes Nirmatrelvir and Ritonavir.

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HIV Infection

Infects immune cells, leading to CD4 cell depletion and eventual AIDs.

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Chronic Suppressive Therapy

Treatment for frequent HSV recurrences; reduces risk of transmission.

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Adverse Effects of Acyclovir

Generally well tolerated; rare nephrotoxicity and CNS symptoms can occur.

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COVID-19 Medications

Includes Remdesivir, Paxlovid, glucocorticoids, and monoclonal antibodies.

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Study Notes

Antimicrobial Therapy

  • Antibiotics are life-saving drugs.
  • Antibiotics only treat bacterial infections.
  • Many sore throats do not require an antibiotic.
  • Some ear infections do not require an antibiotic.
  • Green colored mucus is not a sign that an antibiotic is needed.
  • Risks exist when taking prescription drugs.
  • Consult a clinician about safe antibiotic use.

Some Semantics

  • Antibiotics inhibit or kill pathogens.
  • Antibacterial drugs target bacteria.
  • Antifungal drugs target fungi.
  • Antiviral drugs target viruses.

Empiric Therapy

  • Empiric therapy is the common use of antibiotics in clinical medicine.
  • Therapy is started before culture and sensitivity results are known.
  • Antibiotic selection is based on typical pathogens associated with an infection.
  • Definitive identification of a causative organism takes up to 48 hours.
  • Delay in treatment can be harmful.
  • Combination therapy is sometimes used.
  • Broader spectrum antibiotics are often used.

Definitive Therapy

  • Definitive therapy is tailored to culture and sensitivity results.
  • The provider knows exactly which antibiotics will work.
  • Adjustments to empiric therapy may be needed.
  • Monotherapy is preferred.
  • Narrow spectrum antibiotics are preferred to reduce drug resistance.

Gram Stain vs. Bacterial Culture

  • Gram stain indicates the possible bacterial cause of an illness.
  • It differentiates bacteria based on cell wall characteristics.
  • Gram stain results are quicker than bacterial culture results.
  • Bacterial culture can take 24-48 hours.
  • Culture results allow for targeted therapy against the specific organism.

Bacteria Review

  • Gram-positive bacteria are one type of bacteria.
  • Gram-negative bacteria are another type of bacteria.
  • Atypical bacteria include Spirochetes, Rickettsia, Mycobacteria, Mycoplasma, and Legionella.

Gram-Positive Cocci

  • Staphylococcus aureus
  • Staphylococcus epidermis
  • Streptococcus pneumonia
  • Streptococcus pyogenes (GAS)
  • Streptococcus agalactiae (GBS)
  • Enterococci
  • E. faecalis

Gram-Positive Rods

  • Clostridia
  • C. tetani
  • C. botulinum
  • C. difficile
  • Corynebacterium
  • C. diphtheria
  • Listeria
  • L. monocytogenes

Gram-Negative Bacteria

  • Enterobacteriaceae
  • E. coli
  • Proteus
  • Klebsiella
  • Shigella
  • Salmonella
  • Yersinia
  • Citrobacter
  • UTI
  • Pneumonia
  • Diarrhea
  • Sepsis
  • Nitrite producers
  • Non-fermenters
  • Moraxella
  • Pseudomonas
  • Antibiotic resistance
  • Neisseria
  • Chlamydia
  • Haemophilus
  • H. pylori

Gram Positive vs. Gram Negative

  • Gram-positive bacteria have a thick peptidoglycan layer.
  • Gram-negative bacteria have a thin peptidoglycan layer.

Bactericidal vs. Bacteriostatic

  • Bactericidal drugs kill bacteria.
  • Bacteriostatic drugs prevent bacteria from growing and reproducing.
  • Penicillins, Cephalosporins, Aminoglycosides, Vancomycin, Fluoroquinolones, and Metronidazole are bactericidal drugs.
  • Bactericidal drugs frequently interrupt cell wall or DNA synthesis.
  • Chloramphenicol, Erythromycin, Clindamycin, Sulfonamides, Trimethoprim, and Tetracyclines are bacteriostatic.

Mnemonic

  • ECSTaTiC – refers to bacteriostatic drugs
  • Very ProFicient At Complete Cell Murder – refers to bacteriocidal drugs

Spectrum of Activity

  • Broad spectrum covers a wide range of bacteria (gram +, gram-, and atypicals).
  • This is good for empiric therapy, but increases infections and resistance.
  • Narrow spectrum is preferred when the causative organism is known.
  • It reduces resistance and superinfections, and is targeted therapy.

Keys to Effective Antibiotic Use

  • Identify the organism causing the disease.
  • Confirm if the drug is effective against the organism.
  • Evaluate if there are any risks to the patient.
  • Confirm the drug can reach the site of infection in the body.
  • Assess if the drug stays in the body long enough for effectiveness.

Antibiotic Targets

  • Cell wall synthesis, Folate synthesis, Nucleic acid synthesis, Cell membrane, Protein synthesis.

Mechanisms of Antibiotic Resistance

  • Enzymatic or metabolic inactivation.
  • Alteration of target site
  • Efflux pumps
  • Reduced permeability
  • Alteration of metabolic pathways
  • Biofilms formation
  • Horizontal Gene Transfer

How Antibiotic Resistance Happens

  • Resistant germs exist and when antibiotics kill pathogens, they also kill beneficial bacteria in the body, weakening the body's ability to resist infection.
  • Antibiotic-resistant bacteria increase and take over.
  • Resistant bacteria can spread that resistance to other bacteria, creating further issues.

Other sections (as provided in the prompt)

  • All the other sections (MRSA, Pseudomonas, EMRA Antibiotic Guide...etc) are here with the provided information.
  • Note:* There was no new information provided about these sections to add more details.

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