Microbiology of the Respiratory System
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Questions and Answers

What is the primary role of normal microbiota in the upper respiratory system?

  • To produce mucus for filtering air
  • To suppress pathogens through competitive inhibition (correct)
  • To break down particulate matter in the air
  • To aid in gas exchange in alveoli
  • Which of the following statements about the lower respiratory system is true?

  • It is the primary site of pathogen growth.
  • It contains a diverse range of microbiota.
  • It has a higher density of immune cells than the upper respiratory system.
  • It is predominantly sterile under normal conditions. (correct)
  • What role do alveolar macrophages play in respiratory health?

  • They exercise competitive inhibition against bacteria.
  • They facilitate the exchange of oxygen and carbon dioxide.
  • They produce mucus to trap pathogens.
  • They serve as a first line of defense against inhaled pathogens. (correct)
  • What is the primary function of hairs in the nasal passages?

    <p>To filter and trap particles from inhaled air (C)</p> Signup and view all the answers

    How does competitive inhibition help maintain respiratory health?

    <p>It allows beneficial microbes to outcompete harmful pathogens. (C)</p> Signup and view all the answers

    What type of bacteria causes diphtheria?

    <p>Corynebacterium diphtheriae (B)</p> Signup and view all the answers

    Which symptom is associated with diphtheria?

    <p>Gray membrane formation in the throat (C)</p> Signup and view all the answers

    How is diphtheria primarily treated?

    <p>Antibiotics and antitoxins (A)</p> Signup and view all the answers

    What vaccine is used to prevent diphtheria?

    <p>DTaP vaccine (B)</p> Signup and view all the answers

    Which of the following is a common pathogen associated with otitis media?

    <p>Haemophilus influenzae (B)</p> Signup and view all the answers

    Which anatomical structure is NOT part of the lower respiratory system?

    <p>Tonsils (C)</p> Signup and view all the answers

    What is the function of the epiglottis in the respiratory system?

    <p>To prevent food from entering the trachea (B)</p> Signup and view all the answers

    Which of the following structures serves as a voice box in the lower respiratory system?

    <p>Larynx (B)</p> Signup and view all the answers

    Which structure is responsible for conducting air from the throat to the lungs?

    <p>Trachea (D)</p> Signup and view all the answers

    What role do bronchioles have in the respiratory system?

    <p>They distribute air to the alveoli (D)</p> Signup and view all the answers

    Which part of the respiratory system is primarily involved in gas exchange?

    <p>Alveoli (C)</p> Signup and view all the answers

    What anatomical structure connects the pharynx to the lungs?

    <p>Trachea (B)</p> Signup and view all the answers

    Which component is responsible for regulating airflow in the respiratory system?

    <p>Bronchioles (A)</p> Signup and view all the answers

    What is the primary causative agent of streptococcal pharyngitis?

    <p>Streptococcus pyogenes (D)</p> Signup and view all the answers

    Which symptom is NOT commonly associated with streptococcal pharyngitis?

    <p>Coughing (C)</p> Signup and view all the answers

    What is the recommended treatment for streptococcal pharyngitis?

    <p>Penicillin (A)</p> Signup and view all the answers

    What complication can arise from untreated streptococcal pharyngitis?

    <p>Scarlet fever (C)</p> Signup and view all the answers

    How is the diagnosis of streptococcal pharyngitis commonly confirmed?

    <p>Enzyme immunoassay (EIA) tests (C)</p> Signup and view all the answers

    Which factor contributes to the virulence of Streptococcus pyogenes?

    <p>Cytotoxic streptolysins (A)</p> Signup and view all the answers

    Which other condition is commonly associated with streptococcal pharyngitis?

    <p>Otitis media (D)</p> Signup and view all the answers

    Which of the following statements about scarlet fever is correct?

    <p>It is caused by a toxin from Streptococcus pyogenes. (B)</p> Signup and view all the answers

    Which bacterial species is associated with the appearance of a grayish membrane in the throat?

    <p>Corynebacterium diphtheriae (A)</p> Signup and view all the answers

    Which of the following diseases is NOT routinely prevented through childhood immunization?

    <p>Streptococcus pyogenes infection (C)</p> Signup and view all the answers

    What is the characteristic feature of Bordetella pertussis?

    <p>Gram-negative coccobacillus (B)</p> Signup and view all the answers

    During which stage of whooping cough do prolonged coughing fits with a 'whooping' sound occur?

    <p>The paroxysmal stage (D)</p> Signup and view all the answers

    What is the transmission route for Mycobacterium tuberculosis?

    <p>Airborne transmission (B)</p> Signup and view all the answers

    What type of bacteria is known for having a capsule and damaging ciliated cells in the respiratory tract?

    <p>Bordetella pertussis (B)</p> Signup and view all the answers

    Which of the following respiratory diseases is caused by an acid-fast rod?

    <p>Tuberculosis (D)</p> Signup and view all the answers

    What is a common symptom of infections caused by Streptococcus pyogenes?

    <p>Sore throat and fever (A)</p> Signup and view all the answers

    Which virus is NOT typically associated with the common cold?

    <p>Simplex virus (A)</p> Signup and view all the answers

    What percentage of common cold cases is caused by rhinoviruses?

    <p>30–50% (C)</p> Signup and view all the answers

    Which complication is NOT commonly associated with the common cold?

    <p>Pneumonia (C)</p> Signup and view all the answers

    Which of the following is true regarding treatment for the common cold?

    <p>Cough suppressants can reduce discomfort (A)</p> Signup and view all the answers

    How long do symptoms of the common cold typically last?

    <p>5-7 days (C)</p> Signup and view all the answers

    Which type of coronavirus is associated with the common cold?

    <p>Alphacoronavirus (D)</p> Signup and view all the answers

    What is the approximate percentage of common colds caused by coronaviruses?

    <p>10–15% (C)</p> Signup and view all the answers

    Which symptom is most explicitly linked to a complication of the common cold?

    <p>Headache (D)</p> Signup and view all the answers

    Flashcards

    Respiratory tract microbiota

    Microorganisms that naturally reside in the respiratory system.

    Competitive inhibition

    When normal microbiota use resources, preventing harmful microbes from using them.

    Upper respiratory system microbiota

    Microbes in the nasal passages and other upper parts of the respiratory system.

    Lower respiratory system sterility

    The lower respiratory tract is largely devoid of microbes.

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    Alveolar macrophage

    Specialized immune cells protecting the lower respiratory tract.

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    Pharynx

    The throat, a part of the throat that connects the oral cavity and nasal cavity to the esophagus and larynx.

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    Larynx

    The voice box, a part of the respiratory system that contains the vocal cords.

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    Trachea

    The windpipe, a tube that carries air from the larynx to the lungs.

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    Esophagus

    The tube that carries food from the pharynx to the stomach.

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    Oral Cavity

    Mouth, the initial part of the digestive system.

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    Tongue

    Muscular organ in the oral cavity used for tasting, chewing, and swallowing.

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    Epiglottis

    A flap of cartilage that covers the windpipe during swallowing.

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    Tonsils

    Lymphoid tissues in the throat that help fight infection.

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    Streptococcal Pharyngitis

    A throat infection caused by Streptococcus pyogenes bacteria.

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    Streptococcus pyogenes

    The bacteria that cause strep throat.

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    Symptoms of Strep Throat

    Local inflammation, fever, swelling, tonsillitis, and otitis media (ear infection).

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    Treatment for Strep Throat

    Penicillin antibiotics.

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    Scarlet Fever

    A strep throat-related illness that causes pink-red rash and high fever.

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    Erythrogenic toxin

    A toxin produced by lysogenized Streptococcus pyogenes bacteria causing scarlet fever symptoms.

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    Diagnosis of Strep Throat

    Using enzyme immunoassay (EIA) tests.

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    Pharyngitis

    Inflammation of the pharynx (throat).

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    Diphtheria

    A bacterial infection caused by Corynebacterium diphtheriae, characterized by a sore throat, fever, and a gray membrane forming in the throat.

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    Diphtheria Toxin

    A toxin produced by Corynebacterium diphtheriae that causes the characteristic symptoms of diphtheria, including the formation of the gray membrane in the throat.

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    Otitis Media

    An infection of the middle ear, commonly caused by bacteria like Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella catarrhalis, leading to ear pain, fever, and fluid buildup behind the eardrum.

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    S. pneumoniae in Otitis Media

    Streptococcus pneumoniae, a common cause of otitis media, is often responsible for about 35% of cases.

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    How does the DTaP vaccine prevent diphtheria?

    The DTaP vaccine contains diphtheria toxoid, which is a weakened form of the diphtheria toxin. This exposes the body to the toxoid, allowing it to develop immunity without causing disease.

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    Common Cold Causative Viruses

    The common cold can be caused by a variety of viruses, but the two most prevalent are rhinoviruses (accounting for 30-50% of cases) and coronaviruses (accounting for 10-15%).

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    Common Cold Symptoms Duration

    Symptoms of the common cold typically last for about a week.

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    Common Cold Treatment Effectiveness

    While cough suppressants and antihistamines can help alleviate discomfort, no medication can actually speed up recovery from a common cold.

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    Common Cold Complications

    Common cold complications include laryngitis (inflammation of the voice box) and otitis media (middle ear infection).

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    Simplex Virus HHV-1

    Simplex virus human alphaherpesvirus (HHV-1), commonly known as herpes simplex virus, is NOT a cause of the common cold.

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    Alphacoronavirus

    Alphacoronaviruses are a type of virus that can cause the common cold.

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    Betacoronavirus

    Betacoronaviruses are a type of virus that can cause the common cold.

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    Enterovirus Rhinovirus

    Enterovirus rhinoviruses are a type of virus that can cause the common cold.

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    Pertussis (Whooping Cough)

    A highly contagious respiratory disease caused by Bordetella pertussis bacteria, characterized by severe coughing spells, often resulting in a whooping sound.

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    Paroxysmal Stage

    The stage of pertussis marked by severe, prolonged coughing spasms, often ending with a whooping intake of breath.

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    Tuberculosis

    A chronic bacterial infection caused by Mycobacterium tuberculosis, mainly affecting the lungs but potentially affecting other organs, spreading through airborne transmission.

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    Mycobacterium tuberculosis

    The bacteria responsible for tuberculosis, known for its acid-fastness, meaning it resists decolorization during staining.

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    Acid-fast bacteria

    Bacteria that retain their red stain even after being treated with acid alcohol, which is used to decolorize other types of bacteria.

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    Bronchitis

    Inflammation of the bronchi in the lower respiratory tract, often caused by viruses and leading to coughing, shortness of breath, and wheezing.

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    Bronchiolitis

    Inflammation of the bronchioles (small airways) in the lower respiratory tract, often caused by viruses, especially in infants, and leading to wheezing and difficulty breathing.

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    Study Notes

    Normal Microbiota of the Respiratory System

    • Suppress pathogens through competitive inhibition in the upper respiratory system
    • The lower respiratory system is generally sterile, primarily due to alveolar macrophages

    Test Your Understanding (Respiratory Tract)

    • Nasal hairs function to filter inhaled air
    • Lower respiratory tract is mostly sterile due to the actions of alveolar macrophages

    Test Your Understanding (Respiratory Diseases)

    • The lower respiratory system is comprised of the lungs, bronchi, and trachea
    • The pharynx is part of the upper respiratory system

    Streptococcal Pharyngitis (Strep Throat)

    • Causative agent: Streptococcus pyogenes
    • Resistant to phagocytosis
    • Symptoms: local inflammation and fever; swelling of tonsils and potential ear infections
    • Diagnosis via enzyme immunoassay (EIA) tests
    • Treatment: penicillin
    • Scarlet fever: related condition with pink-red rash and fever, produced by erythrogenic toxins from lysogenized S. pyogenes.

    Diphtheria

    • Causative agent: Corynebacterium diphtheriae, gram-positive rod
    • Symptoms: sore throat, fever, malaise, swelling of the neck; gray membrane formation
    • Diagnosis via tests for presence of diphtheria toxin
    • Treatment: antibiotics and antitoxins
    • Prevention through DTaP vaccine (diphtheria toxoid)

    Otitis Media

    • Common bacterial causes:
      • S. pneumoniae
      • H. influenzae
      • M. catarrhalis
      • S. pyogenes
      • S. aureus
    • Incidence of S. pneumoniae reduced by vaccine

    Common Cold

    • Primarily caused by rhinoviruses (~30-50%) and coronaviruses (~10-15%)
    • Symptoms last about a week, with complications possible such as laryngitis and otitis media
    • Cough suppressants and antihistamines can ease discomfort, but don't hasten recovery

    Upper Respiratory Diseases

    • Pharyngitis (sore throat)
    • Laryngitis (inflammation of larynx)
    • Tonsillitis (inflammation of tonsils)
    • Sinusitis (inflammation of sinuses)
    • Epiglottitis (inflammation of epiglottis), often due to H. influenzae type b

    Lower Respiratory System Diseases- Pertussis (Whooping Cough)

    • Causative agent: Bordetella pertussis
    • Symptoms characterized by stages including catarrhal, paroxysmal, and convalescent
    • Severity in paroxysmal stage with prolonged coughing
    • Transmission through airborne droplets
    • Prevention through DTaP vaccine (acellular Pertussis cell fragments)

    Tuberculosis

    • Causative agent: Mycobacterium tuberculosis
    • Transmitted human-to-human, with a <1% rate from M. bovis
    • Symptoms can vary from initial infection to a mature tubercle
    • Diagnosis involves microscopic examination of sputum, blood tests, and skin tests.
    • Treatment is prolonged (6+ months) multiple antibiotic treatment

    Detection of Tuberculosis

    • Microscopic examination of sputum
    • Blood tests, measuring release of IFN-y from white blood cells
    • Nucleic acid amplification tests (NAATs)
    • Skin test

    Pneumonia (General)

    • Infectious inflammation of the alveoli (air sacs of lungs) characterized by fluid accumulation.
    • Bacterial, viral, or fungal causes

    Haemophilus influenzae Pneumonia

    • Predisposing factors: alcoholism, poor nutrition, cancer, diabetes
    • Symptoms resemble pneumococcal pneumonia
    • Diagnosis by isolation, special media (X and V factors)
    • Treatment: cephalosporins

    Pneumococcal Pneumonia

    • Causative agent: Streptococcus pneumoniae (encapsulated diplococci)
    • Symptoms: infected alveoli, fluid accumulation interfering with oxygen uptake
    • Diagnosis: optochin-inhibition test, bile solubility test, or serological typing tests on bacteria
    • Treatment: macrolides, fluoroquinolones
    • Prevention: pneumococcal vaccines

    Mycoplasmal Pneumonia

    • Causative agent: Mycoplasma pneumoniae (wall-less bacteria)
    • Symptoms: generally mild, respiratory symptoms, cough, headache
    • Diagnosis: PCR, serological (IgM) testing
    • Treatment: tetracyclines

    Legionellosis

    • Causative agent: Legionella pneumophila
    • Transmitted by inhaling aerosols; not by person-to-person
    • Symptoms: potentially fatal pneumonia
    • Diagnostic methods: culture on selective media, DNA probe
    • Treatment: erythromycin

    Psittacosis (Ornithosis)

    • Causative agent: Chlamydophila psittaci
    • Transmitted to humans by elementary bodies from bird droppings; reorganizes into reticulate body in host cells
    • Symptoms: fever, headache, chills
    • Diagnosis via bacteria growth in eggs or cell cultures
    • Treatment: tetracyclines

    Pontiac Fever

    • Causative agent: Legionella pneumophila
    • Mild respiratory infection characterised by fever, muscle aches, and cough
    • Self-limiting condition

    Chlamydial Pneumonia

    • Causative agent: Chlamydophila pneumoniae
    • Transmitted from person to person
    • Affects mostly young people
    • Symptoms resembling mycoplasmal pneumonia
    • Diagnosis via serological tests
    • Treatment: tetracyclines

    Q Fever

    • Causative agent: Coxiella burnetii
    • Reservoir: large mammals; can be contracted from unpasteurized milk
    • Symptoms: mild respiratory disease, complications include endocarditis
    • Diagnosis by detection in cell culture
    • Treatment: doxycycline

    Melioidosis

    • Causative agent: Burkholderia pseudomallei
    • Reservoir: soil
    • Symptoms are pneumonia or tissue abscesses, and severe sepsis
    • Diagnosis: bacterial culture
    • Treatment: ceftazidime

    Pneumocystis Pneumonia

    • Causative agent: Pneumocystis jirovecii
    • Symptoms: Pneumonia, few symptoms if unaffected immune system
    • Diagnosis: microscopy
    • Treatment: trimethoprim

    Blastomycosis

    • Causative agent: Blastomyces dermatitidis
    • Reservoir: soil in the Mississippi valley
    • Symptoms: abscesses, cutaneous ulcers, extensive tissue damage
    • Diagnosis: Isolation of pathogen from pus or biopsy specimens.
    • Treatment: amphotericin B

    Coccidioidomycosis

    • Causative agent: Coccidioides immitis (Valley fever)
    • Reservoir: desert soils of the southwestern U.S.
    • Symptoms: chest pain, fever, and cough
    • Diagnosis: serological tests.
    • Treatment: amphotericin B.

    Case Studies

    (These are presented in the provided text but need details for specific notetaking)

    COVID-19

    • Causative agent: Betacoronavirus SARS-CoV-2
    • Transmission: droplets or aerosols
    • Symptoms: range from minor to severe
    • Diagnostic methods: home ELISA test kits, PCR
    • Treatment: varying, including remdesivir, Paxlovid, and convalescent plasma

    Respiratory Syncytial Virus (RSV)

    • Common in infants; causes significant respiratory infections
    • Causes cell fusion (syncytium) in cell culture
    • Symptoms: pneumonia in infants
    • Diagnosis: serological test
    • Treatment: ribavirin, palivizumab

    Influenza (Flu)

    • Symptoms: chills, fever, aches.
    • Transmission: airborne droplets
    • Diagnosis: PCR or serological test
    • Treatment: zanamivir, oseltamivir
    • Prophylaxis: multivalent vaccine

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    Description

    Explore the role of normal microbiota in the respiratory system, including how they suppress pathogens. Understand the structure of the respiratory tract and related diseases like Streptococcal Pharyngitis. This quiz will test your knowledge of critical concepts and details in respiratory microbiology.

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