Microbiology: Microbial Life and Discovery

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Questions and Answers

What is a microbe?

A microbe is a living organism that requires a microscope to be seen.

All microbes are single-celled organisms.

False (B)

What is the size range of microbes?

Microbes range in size from 0.2 micrometers (µm) to just a few millimeters (mm).

Viruses are larger than the smallest cells.

<p>False (B)</p> Signup and view all the answers

Who developed the first method of DNA sequencing that was fast enough to sequence large genomes?

<p>Fred Sanger</p> Signup and view all the answers

What was the first cellular microbe to have its genome sequenced?

<p>This bacterium, known for causing infections in the respiratory system, was fully sequenced in 1995, marking a significant milestone in microbial genomics.</p> Signup and view all the answers

What are metagenomes?

<p>Metagenomes are collections of sequences from diverse populations of microbes taken directly from the environment.</p> Signup and view all the answers

Which of the following are examples of prokaryotes?

<p>Archaea (D), Bacteria (E)</p> Signup and view all the answers

Which of the following are acellular entities?

<p>Viruses (F)</p> Signup and view all the answers

The bacteria, archaea, and eukaryotes are all thought to have evolved from a common ancestral cell.

<p>True (A)</p> Signup and view all the answers

What are lithotrophs?

<p>Lithotrophs are bacteria that can obtain energy from inorganic compounds.</p> Signup and view all the answers

What historical event profoundly affected human demographics and cultural practices?

<p>The bubonic plague, caused by Yersinia pestis, spread across Europe in the 14th century.</p> Signup and view all the answers

What disease was prevalent in the 19th century?

<p>Tuberculosis, caused by Mycobacterium tuberculosis.</p> Signup and view all the answers

What is AIDS caused by?

<p>AIDS is caused by the human immunodeficiency virus (HIV).</p> Signup and view all the answers

More soldiers have died from wounds in battle than microbial infections.

<p>False (B)</p> Signup and view all the answers

Who was Florence Nightingale?

<p>Florence Nightingale was a British nurse who is known for her work in improving sanitation and healthcare during the Crimean War.</p> Signup and view all the answers

What did Florence Nightingale use to show the deaths of soldiers due to various causes?

<p>Florence Nightingale devised the &quot;polar area chart&quot; to visualize the deaths of soldiers due to various causes, including disease and injuries. The chart was an innovative way to showcase the impact of infections on military losses in a clear and compelling way.</p> Signup and view all the answers

Who built the first compound microscope?

<p>Robert Hooke</p> Signup and view all the answers

What did Robert Hooke use his microscope to observe?

<p>Robert Hooke used his compound microscope to observe mold.</p> Signup and view all the answers

Robert Hooke coined the term "cell" when studying mold.

<p>True (A)</p> Signup and view all the answers

Flashcards

What is a microbe?

A microscopic organism that requires a microscope to be seen.

Microbial Cellular Structure

Organisms with a single cell, but some can form multicellular structures.

Viruses: Acellular Entities

Viruses are acellular entities, much smaller than the smallest cells, requiring a host to multiply.

Genome

The genetic information of an organism, containing instructions for its functions.

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DNA Sequencing

The process of determining the sequence of nucleotides in DNA.

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Sanger Sequencing

The first method of DNA sequencing suitable for large genomes, developed by Fred Sanger.

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Metagenome

Collection of sequences from diverse populations of microbes directly sampled from the environment.

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Prokaryotes

Single-celled organisms lacking a nucleus. Examples include bacteria and archaea.

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Eukaryotes

Organisms with cells containing a nucleus. Examples include algae, fungi, and protists.

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The Three Domains of Life

The three major evolutionary lineages of life: bacteria, archaea, and eukaryotes.

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Influence of Microbes on Human History

Microbes have played crucial roles in shaping human history.

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Microbial Role in Food and Drink

Microbes like yeasts and bacteria were used in the production of fermented foods and beverages.

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Lithtrophs

A type of bacteria that can obtain energy from inorganic compounds like rocks. They play a crucial role in metal mining and the deterioration of ancient stone monuments.

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Microbial Disease and Human Health

Infectious diseases caused by microorganisms have shaped human demographics and cultural practices.

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The Bubonic Plague

The bubonic plague, caused by the bacterium Yersinia pestis, was responsible for significant deaths during the 14th century.

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Tuberculosis

Tuberculosis, caused by the bacterium Mycobacterium tuberculosis, was a major cause of death in the 19th century.

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AIDS

Acquired immunodeficiency syndrome (AIDS), caused by the human immunodeficiency virus (HIV), continues to be a major public health concern.

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Microbes in Warfare

Microbial infections have been significant causes of death in warfare, surpassing battle injuries.

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Florence Nightingale and Medical Statistics

Florence Nightingale, a British nurse, established the science of medical statistics and professional nursing, recognizing the importance of disease in warfare.

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Polar Area Chart

A graphical representation used to show the causes of death among soldiers during the Crimean War, highlighting the impact of infectious disease.

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Robert Hooke and the First Compound Microscope

Robert Hooke, an English scientist, built the first compound microscope and observed mold, contributing to the discovery of the microbial world.

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Micrographia

The first manuscript illustrating objects observed with a microscope, published by Robert Hooke in 1665.

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Cell

The basic unit of life, observed by Robert Hooke through his microscope.

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Diversity of Microbes

Microbes are diverse and include prokaryotes (bacteria, archaea), some eukaryotes (algae, fungi, protists), and acellular entities like viruses and prions.

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Evolution from a Common Ancestor

The process by which organisms evolve from a common ancestor, explaining the diversity of life.

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Haemophilus influenzae

The first cellular microbe sequenced in 1995, paving the way for understanding microbial genomes.

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Bacteria

A single-celled organism that lacks a nucleus and is found in a wide variety of environments.

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Archaea

Single-celled organisms that lack a nucleus and are often found in extreme environments.

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Protists

Single-celled organisms that have a nucleus and include diverse groups like algae, fungi, and protozoa.

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Algae

Microscopic organisms that are often found in water and can produce their own food through photosynthesis.

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Fungi

A group of organisms that includes mushrooms, yeast, and molds.

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Prions

Infectious agents that can cause disease. They are made of a protein and genetic material, but cannot reproduce on their own.

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Study Notes

Microbial Life: Origin and Discovery

  • Microbiology is the study of microbes, organisms too small to be seen without a microscope.
  • Microbes encompass many different types of organisms, including prokaryotes (bacteria and archaea), eukaryotes (algae, fungi, and protists), and viruses and prions.
  • Prokaryotes lack a nucleus, while eukaryotes have a nucleus.
  • Viruses and prions are acellular entities, meaning they are not composed of cells.
  • All three domains of cellular organisms (bacteria, archaea, and eukaryotes) are thought to have evolved from a common ancestor.
  • Microbes range in size from 0.2 micrometers to a few millimeters; viruses are significantly smaller than cells.
  • Microbes are living organisms, but to be seen they require a microscope.
  • The majority of microbes consist of a single cell. However, some microbes, still microscopic, are multicellular but still function as independent individuals instead of a united whole.
  • Microbes play a crucial role in various environments, impacting human history through fermentation, disease, and other processes.

Chapter Overview

  • The chapter covers topics ranging from the definition, history, and characteristics of microbes to their role in human history and biology.
  • The chapter structure is based on a logical progression of concepts.

From Germ to Genome: What is a Microbe?

  • A microbe is any organism that requires a microscope to be seen.
  • Most microbes are single-celled, but some are multicellular.
  • Microbes range in size from 0.2 micrometers (µm) to a few millimeters (mm).
  • Viruses can be 10 times smaller than the smallest cell.
  • Each microbe has the genetic information to reproduce.

Microbes Shape Human History

  • Microbes have shaped human history from the beginning of civilization.
  • Yeasts and bacteria yield fermented foods and beverages, as well as influencing the spoiling of meat and wine respectively.
  • "Rock-eating" bacteria (lithotrophs) help with metal mining and deteriorating ancient stone monuments.
  • Microbes have caused diseases and famines that have affected populations throughout history.

Microbial Disease Devastates Human Populations

  • Microbial diseases have strongly influenced human demographics and cultural practices.
  • Examples include bubonic plague in the 14th century, tuberculosis in the 19th century, and acquired immunodeficiency syndrome (AIDS) in modern times.
  • Soldiers have died, and continue to die, from microbial infections more commonly than from battle wounds.
  • Florence Nightingale (1820-1910) recognized the impact of disease on warfare and helped to establish medical statistics and professional nursing.

Microscopes Reveal the Microbial World

  • Robert Hooke (1635-1703) built the first compound microscope.
  • Hooke used this microscope to observe mold and documented his observations in Micrographia, the first illustrated manuscript of microscopic objects.
  • Hooke coined the term "cell."

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