12 Questions
What is the difference between the cell wall of Chlamydia and a typical Gram-negative bacterium?
Chlamydia lacks a peptidoglycan layer
Why is azithromycin the drug of choice for treating Chlamydia genital infections?
It is not affected by the lack of peptidoglycan and penicillin-binding proteins
What is the characteristic of Chlamydia growth in a cell culture?
It grows in a reticulate body structure
Why are molecular tests preferred for diagnosing Chlamydia infections?
Chlamydia requires cells for growth, making culture-based tests difficult
What is the characteristic of Chlamydia genital infections in women?
They are often asymptomatic or have minimal symptoms
What is the reason for reviewing the choice of molecular target for Chlamydia testing?
To prevent mutant strains from resulting in negative tests
What is the primary reason why Chlamydia cannot be grown on a plate?
It requires a cell culture to replicate
What is the significance of the reticulate bodies in a cell culture?
They are a stage in the life cycle of Chlamydia
Why does Chlamydia not stain with Gram stain despite being Gram-negative?
It has a unique cell wall composition
What is the primary difference between Chlamydia and gonorrhoea genital infections?
Chlamydia causes mucoid discharge, while gonorrhoea causes purulent discharge
Why are two drugs used to treat both gonorrhoea and Chlamydia?
To ensure proper treatment of both infections
What is the primary reason for reviewing the choice of molecular target for Chlamydia testing?
To detect mutant strains that may lead to false negatives
Study Notes
Chlamydia and Gonorrhoea
- Chlamydia is an intracellular bacteria, whereas Gonorrhoea is non-intracellular but becomes intracellular to avoid the immune system.
- Chlamydia cannot be grown on a plate, but can be cultured in cell culture, similar to a virus.
- Chlamydia has a typical Gram-negative cell wall with an inner membrane and outer membrane, but lacks peptidoglycan, which is important for the Gram stain reaction.
- Chlamydia infection is similar to Gonorrhoea, but lacks purulent material and instead presents with mucoid discharge.
- Symptoms of Chlamydia infection include little to no symptoms, but can cause mild inflammation in the cervix, conjunctions, and follicular symptoms (feeling like sand in the eye).
Treatment and Testing
- Azithromycin is the drug of choice for treating Chlamydia and Gonorrhoea infections.
- Penicillin binding proteins are lacking in Chlamydia, making beta-lactam antibiotics ineffective.
- Molecular testing is the preferred method for diagnosing Chlamydia, as it requires cells for growth.
- Testing can be performed on First void urine samples, but the choice of molecular target needs to be reviewed as mutant strains may result in negative molecular tests.
Test your knowledge of Chlamydia, a type of intracellular bacteria, including its growth requirements, cell structure, and Gram staining properties. Learn how Chlamydia interacts with the immune system and its unique characteristics. This quiz is perfect for microbiology students and healthcare professionals.
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