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Questions and Answers
Which characteristic is NOT associated with Yersinia pestis?
Which characteristic is NOT associated with Yersinia pestis?
What is one of the main ways Yersinia pestis spreads in the body after inoculation?
What is one of the main ways Yersinia pestis spreads in the body after inoculation?
Which of the following is a known reservoir for Yersinia pestis?
Which of the following is a known reservoir for Yersinia pestis?
What type of antigen is produced by Yersinia pestis that contributes to its virulence?
What type of antigen is produced by Yersinia pestis that contributes to its virulence?
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Which of the following describes the sylvatic plague cycle?
Which of the following describes the sylvatic plague cycle?
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Study Notes
General Properties of Yersinia pestis
- Non-motile, non-spore-forming, gram-negative bacillus.
- Exhibits pleomorphism and bipolar staining.
- Member of the Enterobacteriaceae family, alongside other pathogenic Yersinia species like Y. pseudotuberculosis and Y. enterocolitica.
- Contains virulence plasmids responsible for producing the F1 antigen, a glycoprotein capsule, and enzymes with various activities such as phospholipase and protease.
Pathogenesis
- Transmitted via lymphatic system from the site of inoculation to regional lymph nodes.
- Ingestion by phagocytes allows Y. pestis to multiply within immune cells.
- Potential for hematogenous spread leading to hemorrhagic lesions in various organs and tissues.
Disease Cycles
- Two primary cycles: sylvatic (wild) and urban (domestic).
- Maintained by specific rodent reservoirs including:
- Rock squirrels
- Ground squirrels
- Prairie dogs
- Mice and voles
- Sylvatic plague predominantly affects animal populations and can enter an enzootic state with low rodent mortality and steady disease levels.
Clinical Presentation and Management
- Requires understanding of specimen collection for culture, treatment options, and preventive measures against plague.
- Presence of virulence factors contributes to the severity and spread of the disease.
- Recognition of disease cycles is crucial for control strategies and public health management.
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Description
This quiz focuses on the microbiological properties of Yersinia pestis and its relationship to the plague. Students will learn about cultural techniques, epidemiology, pathophysiology, and the clinical aspects of plague, including treatment and prevention strategies.
