10 Questions
Which mechanism do intracellular bacteria like Mycobacterium tuberculosis use to escape into the cytosol?
Inhibit fusion of phagosomes with lysosomes
What is the result of viral mechanisms that inhibit class I MHC expression?
Reduced surface expression of class I MHC molecules
Which cells are activated by class I-deficient cells?
NK cells
Which process occurs in chronic viral infections where CD8+ T cells become inactivated and the virus persists?
Exhaustion
What happens to CD8+ T cells in acute viral infections?
They proliferate and differentiate into effector CTLs and memory cells
What is the main difference between acute and chronic viral infections in terms of CD8+ T cell response?
CD8+ T cells clear the virus in chronic infections
Which of the following is a mechanism by which viruses establish chronic infections?
All of the above
What is the term used to describe the phenomenon in which T cells mount an initial response against a virus but the response is prematurely terminated?
T cell exhaustion
Which of the following is an example of a virus that is able to survive in infected persons by killing CD4+ T cells?
Human immunodeficiency virus (HIV)
What is one approach for tilting the balance between the host and microbes in favor of protective immunity?
Enhancing adaptive immune responses through vaccination
Quiz: Mechanisms of Microbial Escape from T Lymphocyte Defense Test your knowledge on the diverse mechanisms that different microbes use to resist T lymphocyte-mediated host defense. Learn about how intracellular bacteria like Mycobacterium tuberculosis, Legionella pneumophila, and Listeria monocytogenes evade phagosome-lysosome fusion or create pores in phagosome membranes to escape into the cytosol. Uncover the strategies employed by these microbes to survive and thrive in the
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