Microbial Escape Tactics

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Questions and Answers

Which mechanism do intracellular bacteria like Mycobacterium tuberculosis use to escape into the cytosol?

  • Inhibit class I MHC–associated antigen presentation
  • Remove newly synthesized class I molecules from the ER
  • Block transport of antigenic peptides from the cytosol into the endoplasmic reticulum
  • Inhibit fusion of phagosomes with lysosomes (correct)

What is the result of viral mechanisms that inhibit class I MHC expression?

  • Increased loading of class I MHC molecules by viral peptides
  • Increased surface expression of class I MHC molecules
  • Reduced surface expression of class I MHC molecules (correct)
  • Reduced loading of class I MHC molecules by viral peptides

Which cells are activated by class I-deficient cells?

  • T lymphocytes
  • B cells
  • NK cells (correct)
  • Phagocytes

Which process occurs in chronic viral infections where CD8+ T cells become inactivated and the virus persists?

<p>Exhaustion (A)</p> Signup and view all the answers

What happens to CD8+ T cells in acute viral infections?

<p>They proliferate and differentiate into effector CTLs and memory cells (D)</p> Signup and view all the answers

What is the main difference between acute and chronic viral infections in terms of CD8+ T cell response?

<p>CD8+ T cells clear the virus in chronic infections (C)</p> Signup and view all the answers

Which of the following is a mechanism by which viruses establish chronic infections?

<p>All of the above (D)</p> Signup and view all the answers

What is the term used to describe the phenomenon in which T cells mount an initial response against a virus but the response is prematurely terminated?

<p>T cell exhaustion (B)</p> Signup and view all the answers

Which of the following is an example of a virus that is able to survive in infected persons by killing CD4+ T cells?

<p>Human immunodeficiency virus (HIV) (B)</p> Signup and view all the answers

What is one approach for tilting the balance between the host and microbes in favor of protective immunity?

<p>Enhancing adaptive immune responses through vaccination (B)</p> Signup and view all the answers

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