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18 Questions

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Microarrays and Their Applications

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Questions and Answers

What are microRNAs (miRNAs)?

Transcripts that are unknown to scientists

Noise in high-density microarrays

Protein-coding genes in the genome

Small noncoding RNAs that regulate gene expression (correct)

How can microarrays be used to measure the expression of microRNAs?

By using probes specific to microRNAs (correct)

By studying protein-coding genes only

By increasing the density of microarray chips

By focusing on unknown transcripts

What are tiling arrays designed for?

Identifying unknown miRNAs

Measuring the abundance of all transcribed parts of the genome (correct)

Detecting noise in high-density microarrays

Studying protein-coding genes

What have scientists found using tiling arrays?

Most parts of the human genome are transcribed Signup and view all the answers

What is proteomics the study of?

All or many proteins Signup and view all the answers

What is the major difference between cDNA microarrays and oligonucleotide microarrays?

The way the probes are prepared Signup and view all the answers

How has the term 'transcriptome' changed over time?

From focusing on mRNA expression to studying all or many transcripts Signup and view all the answers

Which type of microarray is also known as cDNA microarray?

cDNA microarray Signup and view all the answers

What is the main function of DNA microarrays in the field of functional genomics?

Study gene expression patterns Signup and view all the answers

In what type of cell can DNA microarrays be used to identify altered gene expression, such as in cancer cells?

Both prokaryotic and eukaryotic cells Signup and view all the answers

What aspect of gene expression can DNA microarrays help researchers analyze?

Transcriptional regulation Signup and view all the answers

Which technique can DNA microarrays complement in the study of functional genomics?

Mass Spectrometry Signup and view all the answers

What is the typical application of mass spectrometry mentioned in the text?

Measuring mRNA abundances Signup and view all the answers

In mass spectrometry, what does aligning the peaks between different samples allow researchers to do?

Detect differentially expressed proteins Signup and view all the answers

What does ChIP-Chip technique combine ChIP with, according to the text?

DNA microarrays Signup and view all the answers

What is a primary focus of ChIP-Chip technique?

Detecting transcription factor binding sites Signup and view all the answers

How does ChIP-Sequencing help in studying DNA-protein interactions?

By sequencing DNAs bound by specific proteins Signup and view all the answers

What does ChIP-Chip technique help in studying according to the text?

Transcription factor binding sites Signup and view all the answers