MIC541: Virology Section by Michael Belshan
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Questions and Answers

What is the primary characteristic that defines a virus as an obligate intracellular parasite?

  • They can only infect eukaryotic cells.
  • They require host cell metabolic processes and protein synthesis machinery. (correct)
  • They have a cell wall similar to bacteria.
  • They can replicate outside of a host cell.

What is the typical size range of the RNA or DNA genome in a virus?

  • 300-500 nm
  • 20-300 nm (correct)
  • 2-10 nm
  • 10-20 nm

What is unique about the structure of viruses?

  • They all have a icosahedral structure.
  • They all have a helical structure.
  • They have a diverse range of structures, including icosahedral, helical, and others. (correct)
  • They all have a cell wall similar to bacteria.

Where can a virus replicate in a host cell?

<p>In the cytoplasm, the nucleus, or both (B)</p> Signup and view all the answers

What is the size range of human viral pathogens?

<p>20-450 nm (B)</p> Signup and view all the answers

What was the first identified virus?

<p>Tobacco mosaic virus (C)</p> Signup and view all the answers

What is the range of pathogenesis of viruses?

<p>Asymptomatic infections to acute death (C)</p> Signup and view all the answers

What is the primary function of the capsid in a virus?

<p>To protect the genome from environmental variations (C)</p> Signup and view all the answers

What is the term for a single virus particle?

<p>Virion (D)</p> Signup and view all the answers

What type of viral genome is the same as messenger RNA (mRNA)?

<p>Positive sense (+) RNA (B)</p> Signup and view all the answers

What is the term for the process of converting RNA into DNA during a virus's life cycle?

<p>Reverse transcription (B)</p> Signup and view all the answers

What is the main advantage of a viral envelope?

<p>It protects the virus from chemicals and enzymes (A)</p> Signup and view all the answers

What is the purpose of the matrix in a virus?

<p>To associate with the virion membrane (C)</p> Signup and view all the answers

Why do most viruses have a specific host, tissue, or cell type?

<p>Because they require specific cellular pathways (D)</p> Signup and view all the answers

What is the term for the classification of viruses based on their nucleic acid type and replication?

<p>Baltimore classification (B)</p> Signup and view all the answers

What is the term for the shape of a virus with 20 triangular faces and 12 vertices?

<p>Icosahedron (A)</p> Signup and view all the answers

What is a characteristic of DNA viruses that distinguishes them from RNA viruses?

<p>They carry enzymes to increase dNTP pools (B)</p> Signup and view all the answers

Which of the following viruses is limited to infecting mitotically active cells?

<p>Parvovirus (B)</p> Signup and view all the answers

What is the primary site of assembly for enveloped DNA viruses?

<p>Plasma membrane (C)</p> Signup and view all the answers

What is the term for diseases that are naturally transmitted between humans and other vertebrates?

<p>Zoonoses (B)</p> Signup and view all the answers

Which of the following transmission routes is dependent on the stability of the virus in environmental conditions?

<p>Fomites (B)</p> Signup and view all the answers

What is the term for the period between exposure and the onset of symptoms in a viral disease?

<p>Incubation period (D)</p> Signup and view all the answers

Which of the following is an example of a transmission factor that enhances the transmission of a virus?

<p>School holidays (C)</p> Signup and view all the answers

What is the term for the process by which viruses assemble capsids and inject their genome into a host cell?

<p>Assembly (A)</p> Signup and view all the answers

Which of the following is an example of a virus that usurps the ESCRT vesicular budding pathway?

<p>HIV-1 (A)</p> Signup and view all the answers

What is the term for the cells that are targeted by a virus and result in clinical disease?

<p>Target cells (C)</p> Signup and view all the answers

What is the primary factor that determines the absolute measurement of a virus's host range?

<p>Availability of host cell receptors for virus binding (D)</p> Signup and view all the answers

Which of the following is an example of a non-epithelial site where viral infections can initiate?

<p>Skin (C)</p> Signup and view all the answers

What is the result of receptor binding during virus fusion and entry?

<p>Conformation change in envelope protein and fusion with cell membrane (B)</p> Signup and view all the answers

What is the mechanism of endocytosis involved in virus fusion and entry?

<p>Receptor-mediated endocytosis (D)</p> Signup and view all the answers

What is the role of dsRNA in RNA virus replication?

<p>It is an intermediate in RNA replication (B)</p> Signup and view all the answers

What is the purpose of membranous replication complexes in RNA virus replication?

<p>To sequester viral components and protect against innate immunity (A)</p> Signup and view all the answers

What is the limitation of RNA virus genome size?

<p>Maximum of 30,000 nucleotides (C)</p> Signup and view all the answers

What is the mechanism used by RNA viruses to increase genetic capacity?

<p>All of the above (D)</p> Signup and view all the answers

Where does DNA virus replication typically occur?

<p>In the nucleus (A)</p> Signup and view all the answers

What is the role of origin-binding proteins in DNA virus replication?

<p>To bind to the origin of replication (B)</p> Signup and view all the answers

What is the result of the host immune response being stronger than the virus?

<p>Resolution of the infection (D)</p> Signup and view all the answers

What is the typical outcome of most viral infections?

<p>No disease (C)</p> Signup and view all the answers

Which type of viral infection involves an initial acute phase, followed by apparent recovery, and then a secondary disease phase?

<p>Biphasic disease (C)</p> Signup and view all the answers

What is the term for the ability of a virus to establish a long-term infection that can last for many years or a lifetime?

<p>Persistence (C)</p> Signup and view all the answers

Which type of viral infection involves the virus entering a dormant phase, with no symptoms, and can reactivate to cause recurrent infections?

<p>Latent infection (D)</p> Signup and view all the answers

What is the term for the process by which a virus promotes cell growth and survival, leading to an increased tolerance for DNA mutations and ultimately cellular transformation?

<p>Neoplastic transformation (B)</p> Signup and view all the answers

Which type of diagnostic test involves the detection of viral nucleic acids in blood, mucus, excretion, or tissue samples?

<p>PCR or RT-PCR (C)</p> Signup and view all the answers

What is the primary target for the treatment of viral diseases?

<p>Unique viral enzymes (B)</p> Signup and view all the answers

What is the term for the type of vaccine that safely induces an immune response capable of preventing or attenuating illness?

<p>Prophylactic vaccine (D)</p> Signup and view all the answers

What is the purpose of a therapeutic vaccine?

<p>To boost the immune response to reduce pathology (A)</p> Signup and view all the answers

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