Metolazone Drug Flashcards
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Questions and Answers

What is the drug classification of Metolazone?

  • Thiazide-like quinazoline derivative (correct)
  • Beta-blocker
  • Calcium channel blocker
  • ACE inhibitor

What are the common generic and trade names for Metolazone?

Metolazone / Zaroxolyn

The usual dosage range for Metolazone is ____ mg per day.

5-10

What is the typical dosage and route for Metolazone?

<p>PO 5 mg tab</p> Signup and view all the answers

Why is a client receiving Metolazone?

<p>Edema, Hypertension</p> Signup and view all the answers

How does Metolazone work?

<p>Acts on the distal tubule and cortical thick ascending limb of the loop of Henle in kidney, increasing exertion of sodium, water, chloride, magnesium, potassium, and bicarbonate, decreases GFR.</p> Signup and view all the answers

What side effects are most likely to occur due to Metolazone?

<p>Dizziness, fatigue, weakness, orthostatic hypotension, hypokalemia, nausea, vomiting, pancreatitis</p> Signup and view all the answers

What actions should a nurse take specific to Metolazone?

<p>Assess for orthostatic hypotension before, during therapy; monitor blood glucose if patient is diabetic; check for rashes, temperature elevation daily.</p> Signup and view all the answers

What should a nurse teach a client about Metolazone?

<p>Take medication early in the morning to prevent nocturia; take with food or milk if GI symptoms occur; monitor BP and pulse; notify prescriber if muscle cramps, weakness, nausea, dizziness, or numbness occur.</p> Signup and view all the answers

What other medications might interact with Metolazone?

<p>Alcohol: increased hypotension; Antidiabetics: increased hypoglycemia</p> Signup and view all the answers

Study Notes

Drug Classification

  • Metolazone is a thiazide-like quinazoline derivative.

Common Names

  • Generic name: Metolazone
  • Trade name: Zaroxolyn

Dosage Information

  • Usual oral dosage range: 5-10 mg/day, maximum 20 mg/day.
  • Common dosage form: 5 mg tablet taken orally.

Indications

  • Prescribed for conditions like edema and hypertension.

Mechanism of Action

  • Acts on distal tubule and cortical thick ascending limb of the loop of Henle in the kidneys.
  • Increases excretion of sodium, water, chloride, magnesium, potassium, and bicarbonate.
  • Decreases glomerular filtration rate (GFR).

Possible Side Effects

  • Common side effects include dizziness, fatigue, weakness, orthostatic hypotension, hypokalemia, nausea, vomiting, and pancreatitis.

Nursing Responsibilities

  • Monitor for orthostatic hypotension, assessing before and during therapy.
  • Check blood glucose levels for diabetic patients.
  • Observe for skin rashes and daily temperature elevation.

Patient Education

  • Instruct patients to take the medication early in the morning to reduce nocturia.
  • Advise taking with food or milk if gastrointestinal symptoms occur.
  • Teach self-monitoring of blood pressure and pulse, encouraging record-keeping.
  • Stress the importance of notifying the prescriber if muscle cramps, weakness, nausea, dizziness, or numbness occur.

Medication Interactions

  • Alcohol consumption can lead to increased hypotension.
  • Antidiabetic medications can cause increased hypoglycemia when taken with Metolazone.

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Description

This quiz focuses on Metolazone, a thiazide-like diuretic used for treating edema and hypertension. Test your knowledge of its classification, dosage, and common trade names through these flashcards. Perfect for pharmacy students and healthcare professionals.

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