Metolazone Drug Flashcards

Questions and Answers

What is the drug classification of Metolazone?

Thiazide-like quinazoline derivative (correct)

Beta-blocker

Calcium channel blocker

ACE inhibitor

What are the common generic and trade names for Metolazone?

Metolazone / Zaroxolyn

The usual dosage range for Metolazone is ____ mg per day.

5-10

What is the typical dosage and route for Metolazone?

PO 5 mg tab Signup and view all the answers

Why is a client receiving Metolazone?

Edema, Hypertension Signup and view all the answers

How does Metolazone work?

Acts on the distal tubule and cortical thick ascending limb of the loop of Henle in kidney, increasing exertion of sodium, water, chloride, magnesium, potassium, and bicarbonate, decreases GFR. Signup and view all the answers

What side effects are most likely to occur due to Metolazone?

Dizziness, fatigue, weakness, orthostatic hypotension, hypokalemia, nausea, vomiting, pancreatitis Signup and view all the answers

What actions should a nurse take specific to Metolazone?

Assess for orthostatic hypotension before, during therapy; monitor blood glucose if patient is diabetic; check for rashes, temperature elevation daily. Signup and view all the answers

What should a nurse teach a client about Metolazone?

Take medication early in the morning to prevent nocturia; take with food or milk if GI symptoms occur; monitor BP and pulse; notify prescriber if muscle cramps, weakness, nausea, dizziness, or numbness occur. Signup and view all the answers

What other medications might interact with Metolazone?

Alcohol: increased hypotension; Antidiabetics: increased hypoglycemia Signup and view all the answers

Study Notes

Drug Classification

Metolazone is a thiazide-like quinazoline derivative.

Common Names

Generic name: Metolazone
Trade name: Zaroxolyn

Dosage Information

Usual oral dosage range: 5-10 mg/day, maximum 20 mg/day.
Common dosage form: 5 mg tablet taken orally.

Indications

Prescribed for conditions like edema and hypertension.

Mechanism of Action

Acts on distal tubule and cortical thick ascending limb of the loop of Henle in the kidneys.
Increases excretion of sodium, water, chloride, magnesium, potassium, and bicarbonate.
Decreases glomerular filtration rate (GFR).

Possible Side Effects

Common side effects include dizziness, fatigue, weakness, orthostatic hypotension, hypokalemia, nausea, vomiting, and pancreatitis.

Nursing Responsibilities

Monitor for orthostatic hypotension, assessing before and during therapy.
Check blood glucose levels for diabetic patients.
Observe for skin rashes and daily temperature elevation.

Patient Education

Instruct patients to take the medication early in the morning to reduce nocturia.
Advise taking with food or milk if gastrointestinal symptoms occur.
Teach self-monitoring of blood pressure and pulse, encouraging record-keeping.
Stress the importance of notifying the prescriber if muscle cramps, weakness, nausea, dizziness, or numbness occur.

Medication Interactions

Alcohol consumption can lead to increased hypotension.
Antidiabetic medications can cause increased hypoglycemia when taken with Metolazone.

Description

This quiz focuses on Metolazone, a thiazide-like diuretic used for treating edema and hypertension. Test your knowledge of its classification, dosage, and common trade names through these flashcards. Perfect for pharmacy students and healthcare professionals.