Questions and Answers
What is the brand name for Methylergonovine?
Methergine
What is the therapeutic classification for Methergine?
Oxytocic
What is the pharmacologic class for Methylergonovine?
Ergot Alkaloids
What are the indications for Methergine?
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What is uterine atony?
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What is involution in relation to the uterus?
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What is the action of Methergine?
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What are the therapeutic effects of Methergine?
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How can Methergine be administered?
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What is known about the distribution of Methergine?
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How is Methergine metabolized and excreted?
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In what scenario is Methergine contraindicated in obstetrics?
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What is a contraindication for Methergine during lactation?
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Who should use Methergine cautiously?
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What are some adverse reactions to Methergine?
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Why should Methergine not be administered intravenously routinely?
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What risks do patients with coronary artery disease face when using Methergine?
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What effect can Ergot Alkaloids cause?
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What is the uterotonic effect of Methergine after delivery?
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What should be assessed in a nursing evaluation for Methergine?
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Study Notes
Methylergonovine Overview
- Brand name: Methergine
- Classification: Therapeutic - oxytocic; Pharmacologic - Ergot Alkaloids
Drug Class Characteristics
- Oxytocic Drugs: Promote uterine contractions to accelerate childbirth and prevent postpartum hemorrhage.
- Ergot Alkaloids: Enhance contraction rate and strength while increasing uterine muscle stiffness.
Indications
- Used for prevention and treatment of postpartum or postabortion hemorrhage due to uterine atony or subinvolution.
Uterine Conditions
- Uterine Atony: Relaxation of the uterus that leads to postpartum hemorrhage; results from failure of the uterine muscle to contract effectively.
- Subinvolution: Failure of the uterus to return to its normal size post-enlargement due to functional activity.
- Involution: Reduction in size of the uterus after birth, returning to its nonpregnant state.
Mechanism of Action
- Stimulates uterine and vascular smooth muscle directly.
Therapeutic Effects
- Promotes uterine contraction.
Pharmacokinetics
- Absorption: Administered orally or via intramuscular (IM) injection.
- Distribution: Unknown distribution profile; enters breast milk in small amounts.
- Metabolism & Excretion: Likely metabolized by the liver.
Contraindications
- Not for inducing labor in obstetric patients.
- Contraindicated in lactation; avoid breastfeeding during treatment and for 12 hours post-dose.
- Use cautiously in patients with hypertension or eclampsia due to increased susceptibility to side effects.
Adverse Reactions
- CNS: Stroke, dizziness, headache.
- Cardiovascular: Hypertension, arrhythmias, AV block, chest pain, palpitations.
- Gastrointestinal: Nausea/Vomiting (N/V).
- Genitourinary: Cramps.
- Neurological: Paresthesia.
Administration Considerations
- Avoid routine IV administration due to risk of sudden hypertensive crises and cerebrovascular accidents.
- Patients with coronary artery disease or risk factors (e.g., smoking, obesity, diabetes, high cholesterol) may have increased risk of myocardial ischemia and infarction.
Additional Effects
- Ergot Alkaloids can cause vasoconstriction, which is an important consideration in management.
- Uterotonic effect of Methergine assists involution and decreases hemorrhage, thus shortening the third stage of labor.
Nursing Assessment
- Monitor blood pressure (BP), heart rate (HR), and uterine response closely during treatment.
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Description
Test your knowledge on Methylergonovine, also known as Methergine, through these flashcards. Learn about its therapeutic classification, pharmacologic class, and its role as an oxytocic drug. Perfect for students in pharmacology or nursing programs!
