18 Questions
What is the role of metal ions in enzyme catalysis for orientation of substrates?
Mediating oxidation-reduction reactions
What is the function of a coenzyme in enzyme catalysis?
Directly participate in the reaction mechanism
Which term describes an enzyme without its bound cofactor?
Apoenzyme
In enzyme catalysis, how do metal ions act similarly to H+?
By stabilizing negative charges
What is the term for enzymes that require a metal ion cofactor for activity?
Metaloenzymes
How do enzymes exhibit specificity towards substrates?
Through charge complementarity
What did Daniel Koshland modify in the 'lock and key' model of enzyme-substrate interaction?
The amino acid side chains making up the active site
Which model explains both enzyme specificity and the stabilization of the transition state?
Induced fit model
In chiral reactions, enzymes are typically:
Stereospecific
What concept from transition state theory helps explain how enzymes catalyze chemical reactions?
Reaction Coordinate
Which statement is true regarding metal ion cofactors in enzymes?
They can alter the shape of the active site
What role do coenzymes play in enzyme-catalyzed reactions?
Facilitate electron transfer reactions
What region of an enzyme contains the catalytic residues and binds the substrate to carry out the reaction?
Active site
Which type of molecules can act as cofactors for enzymes?
Metal ions and organic molecules
What is the role of coenzymes in enzymatic reactions?
To transiently associate with enzymes
Which type of enzymes require metal ions for their catalytic activity?
Metalloenzymes
What is the function of metal ion cofactors in metalloenzymes?
Act as essential components for catalysis
Which type of cofactors are most commonly associated with vitamins?
Coenzymes
Learn about the role of metal ions in catalytic processes, including their involvement in substrate binding, oxidation-reduction reactions, and electrostatic stabilization. Explore how metal ions function similarly to H+ but with more charges and are abundant at neutral pH.
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