Metal Ions in Catalysis

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Questions and Answers

What is the role of metal ions in enzyme catalysis for orientation of substrates?

  • Shielding positive charges
  • Electrostatically stabilizing negative charges
  • Activating the enzyme
  • Mediating oxidation-reduction reactions (correct)

What is the function of a coenzyme in enzyme catalysis?

  • Stabilize the enzyme's active site
  • Directly participate in the reaction mechanism (correct)
  • Assist in substrate binding
  • Provide structural stability to the enzyme

Which term describes an enzyme without its bound cofactor?

  • Coenzyme
  • Holoenzyme
  • Cofactorase
  • Apoenzyme (correct)

In enzyme catalysis, how do metal ions act similarly to H+?

<p>By stabilizing negative charges (A)</p> Signup and view all the answers

What is the term for enzymes that require a metal ion cofactor for activity?

<p>Metaloenzymes (A)</p> Signup and view all the answers

How do enzymes exhibit specificity towards substrates?

<p>Through charge complementarity (A)</p> Signup and view all the answers

What did Daniel Koshland modify in the 'lock and key' model of enzyme-substrate interaction?

<p>The amino acid side chains making up the active site (D)</p> Signup and view all the answers

Which model explains both enzyme specificity and the stabilization of the transition state?

<p>Induced fit model (C)</p> Signup and view all the answers

In chiral reactions, enzymes are typically:

<p>Stereospecific (D)</p> Signup and view all the answers

What concept from transition state theory helps explain how enzymes catalyze chemical reactions?

<p>Reaction Coordinate (A)</p> Signup and view all the answers

Which statement is true regarding metal ion cofactors in enzymes?

<p>They can alter the shape of the active site (A)</p> Signup and view all the answers

What role do coenzymes play in enzyme-catalyzed reactions?

<p>Facilitate electron transfer reactions (D)</p> Signup and view all the answers

What region of an enzyme contains the catalytic residues and binds the substrate to carry out the reaction?

<p>Active site (A)</p> Signup and view all the answers

Which type of molecules can act as cofactors for enzymes?

<p>Metal ions and organic molecules (D)</p> Signup and view all the answers

What is the role of coenzymes in enzymatic reactions?

<p>To transiently associate with enzymes (A)</p> Signup and view all the answers

Which type of enzymes require metal ions for their catalytic activity?

<p>Metalloenzymes (A)</p> Signup and view all the answers

What is the function of metal ion cofactors in metalloenzymes?

<p>Act as essential components for catalysis (D)</p> Signup and view all the answers

Which type of cofactors are most commonly associated with vitamins?

<p>Coenzymes (B)</p> Signup and view all the answers

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