Metabolism Overview Quiz
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Questions and Answers

Which of the following is NOT a component of micelles?

  • Free fatty acids
  • Monoglycerides
  • Cholesterol (correct)
  • Bile salts
  • Where are TAGs repackaged after being digested?

  • Liver
  • Intestinal cells (correct)
  • Lymphatic system
  • Small intestine
  • What is the primary function of chylomicrons?

  • Transporting TAGs from intestinal cells to the bloodstream (correct)
  • Transporting cholesterol from the liver to cells
  • Transporting phospholipids from the liver to cells
  • Transporting TAGs from the liver to cells
  • Which of the following phospholipids is NOT involved in fat transport?

    <p>Triglycerides (A)</p> Signup and view all the answers

    What is the role of pancreatic lipase in lipid digestion?

    <p>It hydrolyzes ester bonds in triglycerides. (D)</p> Signup and view all the answers

    What is the primary function of pepsin in protein digestion?

    <p>It denatures proteins, exposing peptide bonds for further hydrolysis. (B)</p> Signup and view all the answers

    What is the role of HCl in the stomach during protein digestion?

    <p>It activates the enzyme pepsinogen, converting it into the active form pepsin. (D)</p> Signup and view all the answers

    Where does the final digestion of carbohydrates take place?

    <p>Small Intestine (B)</p> Signup and view all the answers

    Which hormone is secreted in response to the arrival of acidified protein in the small intestine?

    <p>Secretin (B)</p> Signup and view all the answers

    Which of the following enzymes is responsible for breaking down starch and glycogen in the mouth?

    <p>α-amylase (C)</p> Signup and view all the answers

    Which of the following enzymes are involved in protein digestion in the small intestine?

    <p>Trypsin, chymotrypsin, and carboxypeptidase. (D)</p> Signup and view all the answers

    What is the primary function of bicarbonate ions (HCO3-) in protein digestion?

    <p>They neutralize the acidic gastric content, creating a more favorable environment for other enzymes. (D)</p> Signup and view all the answers

    Why is carbohydrate digestion limited in the stomach?

    <p>Both A and B (C)</p> Signup and view all the answers

    What is the role of pancreatic α-amylase in carbohydrate digestion?

    <p>It breaks down polysaccharides into disaccharides. (D)</p> Signup and view all the answers

    Which of the following statements about digestion is incorrect?

    <p>The stomach is the primary site for carbohydrate digestion. (A)</p> Signup and view all the answers

    What is the role of bile acids in the digestion of carbohydrates?

    <p>They emulsify dietary lipids, aiding in their digestion. (A)</p> Signup and view all the answers

    What is the primary function of enteropeptidase in the digestive system?

    <p>It activates pancreatic enzymes. (A)</p> Signup and view all the answers

    How are most digestive enzymes secreted?

    <p>As inactive precursors called zymogens. (A)</p> Signup and view all the answers

    Which of the following is NOT a characteristic of catabolism?

    <p>Synthesis of biological macromolecules (D)</p> Signup and view all the answers

    What is the primary function of the duodenum in the digestive process?

    <p>Mixing ingested food and initiating digestion. (C)</p> Signup and view all the answers

    Which of these is a characteristic of the small intestine?

    <p>Majority of digestion and absorption takes place here. (C)</p> Signup and view all the answers

    What is the primary role of bile in digestion?

    <p>Breaking down fats into fatty acids and glycerol. (C)</p> Signup and view all the answers

    Why are most digestive enzymes secreted as inactive precursors?

    <p>To prevent premature digestion in the producing cell. (C)</p> Signup and view all the answers

    What are the main mechanisms used to regulate metabolic pathways?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the difference between catabolic and anabolic pathways?

    <p>Catabolic pathways break down large molecules, while anabolic pathways build up larger molecules. (A)</p> Signup and view all the answers

    Why are catabolic and anabolic pathways not simple reversals of each other?

    <p>They involve different enzymes and require different energy inputs. (D)</p> Signup and view all the answers

    Which enzyme is primarily responsible for the breakdown of lactose into glucose and galactose?

    <p>Lactase (A)</p> Signup and view all the answers

    How do bile salts influence the digestion of lipids?

    <p>Bile salts emulsify lipids, increasing their surface area for enzyme action. (A)</p> Signup and view all the answers

    Which of the following is NOT a product of glucose metabolism in the liver?

    <p>Fructose (A)</p> Signup and view all the answers

    Which of the following statements accurately describes the role of gastric lipase in lipid digestion?

    <p>Gastric lipase hydrolyzes about 10% of triacylglycerols, producing fatty acids and monoacylglycerol. (D)</p> Signup and view all the answers

    Which of the following describes the process of digestion and absorption of carbohydrates?

    <p>Carbohydrates are digested by enzymes in the mouth, stomach, and small intestine, and then absorbed as monosaccharides into the bloodstream. (D)</p> Signup and view all the answers

    Flashcards

    Metabolism

    The sum of all chemical reactions in a cell or organism.

    Catabolism

    The breakdown of large nutrient molecules into smaller ones, producing energy.

    Anabolism

    The production of biological macromolecules through biosynthesis, requiring energy.

    Metabolic Pathways

    A series of biochemical reactions that are not simple reversals of each other.

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    Regulation of Metabolic Pathways

    Control mechanisms like enzyme concentration, activity, and compartmentation.

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    Digestive Process

    The breakdown of food into absorbable components.

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    Zymogens

    Inactive enzyme precursors secreted to prevent premature digestion.

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    Digestive Enzymes

    Catalysts that help break down food, mostly secreted as zymogens.

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    Pancreatic Lipase

    An enzyme that hydrolyzes ester bonds to produce fatty acids and glycerol.

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    Micelles

    Small droplets formed from fatty acids, monoacylglycerol, and bile salts that aid in fat absorption.

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    Chylomicrons

    Lipid transport particles that carry TAGs from intestinal cells to the bloodstream via lymphatic system.

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    Phospholipids

    Lipids formed in the liver that are crucial for nerve and brain tissue formation.

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    Lecithin

    A type of phospholipid that helps transport fats to tissues and is important for brain health.

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    TAG Hydrolysis

    Triacylglycerols (TAGs) are hydrolyzed into fatty acids and glycerol by lipase enzymes in the bloodstream.

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    Fat Storage

    Excess fats are stored in adipocytes, primarily located beneath the skin and around vital organs.

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    Adipose Tissue Functions

    Adipose tissue protects against heat loss and mechanical shock while storing energy.

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    Protein Digestion Start

    Protein digestion begins in the stomach with the release of gastrin and activation of pepsinogen by HCl.

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    Secretin Hormone

    Secretin stimulates bicarbonate production and activates pancreatic enzymes in response to acidified proteins in the small intestine.

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    Maltase

    An enzyme that hydrolyzes maltose into glucose.

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    Sucrase

    An enzyme that hydrolyzes sucrose into glucose and fructose.

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    Lactase

    An enzyme that hydrolyzes lactose into glucose and galactose.

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    Absorption of Monosaccharides

    Glucose, galactose, and fructose are absorbed into the bloodstream.

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    Gastric Lipase

    An enzyme that hydrolyzes TAGs in the stomach into fatty acids and monoacylglycerol.

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    Inactive precursors

    Digestive enzymes secreted in an inactive form called zymogens before activation.

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    Protease

    Enzyme that digests proteins by breaking down peptide bonds.

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    Lipase

    Enzyme that digests fats by breaking down lipids into fatty acids.

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    Activation of zymogens

    Zymogens can be activated by pH changes or by specific enzymes like enteropeptidase.

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    α-amylase

    Salivary enzyme that begins carbohydrate digestion in the mouth.

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    Carbohydrate digestion site

    The primary site for carbohydrate digestion is the small intestine.

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    Function of bile acids

    Bile acids emulsify fats in the intestine to facilitate digestion and absorption.

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    Mucosal cell digestion

    Final carbohydrate digestion occurs on membranes of intestinal mucosal cells.

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    Study Notes

    Metabolism

    • Metabolism: The sum of all chemical reactions in a cell or organism.
    • Pathway: A series of biochemical reactions
    • Catabolism: Breakdown of large nutrient molecules into smaller molecules with the concurrent production of energy. Catabolism is generally accompanied by a net release of energy.
    • Anabolism: Production of biological macromolecules through biosynthesis. Anabolism requires a net input of chemical energy.
    • Catabolic and anabolic pathways with the same end points are not simple reversals of each other. Each pathway must be thermodynamically favorable in its own direction.
    • Metabolic pathways are regulated by several mechanisms, including control of enzyme concentration, enzyme activity, and enzyme compartmentation.

    Overview of Metabolism

    • Nutrients: Fats, polysaccharides, and proteins are involved in both catabolism and anabolism.
    • Catabolism: Oxidative process that converts nutrients into energy-releasing products.
    • Anabolism: Reductive process requiring energy input to produce biological macromolecules including proteins, lipids, and nucleic acids.
    • Some nutrients and products of catabolism require reducing agents and energy.

    Digestive System and Digestive Juices

    • Digestion: The process by which food is broken down into components simple enough to be absorbed in the intestine.
    • The mouth, stomach, and duodenum deal with the initial process of mixing ingested food and initiating digestion.
    • The duodenum receives bile and pancreatic secretions through the common bile duct.
    • The small intestine is the main digestive area (jejunum and ileum). Absorption is initiated in the jejunum and continues through the ileum.
    • The large intestine (specifically the colon) is primarily involved in absorbing electrolytes and water.

    Digestive System and Digestive Juices - Details

    • Most digestive enzymes are secreted as inactive precursors (zymogens)
    • Enzymes involved in digesting proteins are secreted as inactive zymogens. Activation occurs when released to the gut lumen
    • Activation can also happen due to change in pH or by enzyme activation by other enzymes.
    • Secretion and function of enzymes is similar in salivary glands, gastric mucosa, and pancreas

    Digestion and Absorption of Carbohydrates

    • Carbohydrate digestion begins in the mouth with salivary a-amylase hydrolyzing some a-glycosidic linkages.
    • Little carbohydrate digestion occurs in the stomach due to food being swallowed quickly.
    • Stomach acidity inactivates the salivary amylase.
    • The primary site for carbohydrate digestion is the small intestine.
    • Pancreatic a-amylase further breaks down polysaccharides into disaccharides, which are then hydrolyzed by enzymes (maltase, sucrase, lactase) on the surface of the intestinal mucosal cells into monosaccharides.
    • Monosaccharides (glucose, fructose, galactose) are absorbed by active transport into intestinal lining cells, and then enter the bloodstream.
    • Galactose and fructose are converted to glucose intermediates in the liver prior to entering glycolysis.
    • Glucose may be converted to glycogen for storage in the liver or tissues, oxidized for energy production or converted to fat.

    Digestion and Absorption of Lipids

    • Dietary lipids are mainly triacylglycerols (TAGs).
    • Salivary enzymes have no effect on lipids in the mouth.
    • In the stomach, TAGs are physically broken down into smaller globules. Gastric lipases start the hydrolysis of TAGs ( ~ 10%).
    • Bile salts emulsify fat globules in the small intestine.
    • Pancreatic lipases further hydrolyze TAGs producing fatty acids and monoacylglycerols.
    • These products form micelles, which are absorbed into intestinal cells.
    • Inside the cells, the products are reassembled into TAGs, packaged with cholesterol and phospholipids into chylomicrons for transport through the lymphatic system to the bloodstream.

    Digestion and Absorption of Proteins

    • Protein digestion begins in the stomach.
    • HCI denatures proteins and activates pepsinogen to pepsin.
    • Pepsin hydrolyzes peptide bonds.
    • Large polypeptides pass from the stomach to the small intestine where additional enzymes (trypsin, chymotrypsin, carboxypeptidase, aminopeptidase) hydrolyze peptides further into oligopeptides and amino acids.
    • Amino acids are absorbed into the bloodstream via active transport.

    Summary of Intermediary Metabolism (Anabolism & Catabolism)

    • Anabolism (reduction): Synthesis of simple organic compounds from inorganic components like CO2 and H2O.
    • Catabolism (oxidation): Conversion of carbon in metabolic fuels to an activated 2-carbon fragment (acetyl-CoA).
    • Catabolism is usually accompanied by a net release of energy.
    • Anabolism typically requires a net input of energy.
    • Metabolic pathways have intermediate steps which are often reversible in vivo but some are not and these irreversible steps are important regulatory points in the pathway.
    • The activity of many metabolic pathways is controlled by multiple factors inside and outside the cell.

    Cellular Respiration (Oxidation of Acetyl-CoA)

    • The citric acid cycle is a key part of cellular respiration.
    • Cellular respiration takes place in the mitochondria.
    • This process includes glycolysis, a key component before entering the citric acid cycle, converting glucose to pyruvate and capturing a small amount of energy
    • Intermediate reactions occur before full oxidation and the generation of ATP via the electron transport chain and an associated process--oxidative phosphorylation.

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    Description

    Test your knowledge on metabolism with this quiz, focusing on catabolism and anabolism. Explore biochemical pathways, nutrient roles, and the regulation of metabolic processes. Perfect for students learning about cellular biology.

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