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Questions and Answers
Which of the following is NOT a component of micelles?
Which of the following is NOT a component of micelles?
Where are TAGs repackaged after being digested?
Where are TAGs repackaged after being digested?
What is the primary function of chylomicrons?
What is the primary function of chylomicrons?
Which of the following phospholipids is NOT involved in fat transport?
Which of the following phospholipids is NOT involved in fat transport?
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What is the role of pancreatic lipase in lipid digestion?
What is the role of pancreatic lipase in lipid digestion?
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What is the primary function of pepsin in protein digestion?
What is the primary function of pepsin in protein digestion?
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What is the role of HCl in the stomach during protein digestion?
What is the role of HCl in the stomach during protein digestion?
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Where does the final digestion of carbohydrates take place?
Where does the final digestion of carbohydrates take place?
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Which hormone is secreted in response to the arrival of acidified protein in the small intestine?
Which hormone is secreted in response to the arrival of acidified protein in the small intestine?
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Which of the following enzymes is responsible for breaking down starch and glycogen in the mouth?
Which of the following enzymes is responsible for breaking down starch and glycogen in the mouth?
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Which of the following enzymes are involved in protein digestion in the small intestine?
Which of the following enzymes are involved in protein digestion in the small intestine?
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What is the primary function of bicarbonate ions (HCO3-) in protein digestion?
What is the primary function of bicarbonate ions (HCO3-) in protein digestion?
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Why is carbohydrate digestion limited in the stomach?
Why is carbohydrate digestion limited in the stomach?
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What is the role of pancreatic α-amylase in carbohydrate digestion?
What is the role of pancreatic α-amylase in carbohydrate digestion?
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Which of the following statements about digestion is incorrect?
Which of the following statements about digestion is incorrect?
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What is the role of bile acids in the digestion of carbohydrates?
What is the role of bile acids in the digestion of carbohydrates?
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What is the primary function of enteropeptidase in the digestive system?
What is the primary function of enteropeptidase in the digestive system?
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How are most digestive enzymes secreted?
How are most digestive enzymes secreted?
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Which of the following is NOT a characteristic of catabolism?
Which of the following is NOT a characteristic of catabolism?
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What is the primary function of the duodenum in the digestive process?
What is the primary function of the duodenum in the digestive process?
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Which of these is a characteristic of the small intestine?
Which of these is a characteristic of the small intestine?
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What is the primary role of bile in digestion?
What is the primary role of bile in digestion?
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Why are most digestive enzymes secreted as inactive precursors?
Why are most digestive enzymes secreted as inactive precursors?
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What are the main mechanisms used to regulate metabolic pathways?
What are the main mechanisms used to regulate metabolic pathways?
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What is the difference between catabolic and anabolic pathways?
What is the difference between catabolic and anabolic pathways?
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Why are catabolic and anabolic pathways not simple reversals of each other?
Why are catabolic and anabolic pathways not simple reversals of each other?
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Which enzyme is primarily responsible for the breakdown of lactose into glucose and galactose?
Which enzyme is primarily responsible for the breakdown of lactose into glucose and galactose?
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How do bile salts influence the digestion of lipids?
How do bile salts influence the digestion of lipids?
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Which of the following is NOT a product of glucose metabolism in the liver?
Which of the following is NOT a product of glucose metabolism in the liver?
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Which of the following statements accurately describes the role of gastric lipase in lipid digestion?
Which of the following statements accurately describes the role of gastric lipase in lipid digestion?
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Which of the following describes the process of digestion and absorption of carbohydrates?
Which of the following describes the process of digestion and absorption of carbohydrates?
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Flashcards
Metabolism
Metabolism
The sum of all chemical reactions in a cell or organism.
Catabolism
Catabolism
The breakdown of large nutrient molecules into smaller ones, producing energy.
Anabolism
Anabolism
The production of biological macromolecules through biosynthesis, requiring energy.
Metabolic Pathways
Metabolic Pathways
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Regulation of Metabolic Pathways
Regulation of Metabolic Pathways
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Digestive Process
Digestive Process
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Zymogens
Zymogens
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Digestive Enzymes
Digestive Enzymes
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Pancreatic Lipase
Pancreatic Lipase
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Micelles
Micelles
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Chylomicrons
Chylomicrons
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Phospholipids
Phospholipids
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Lecithin
Lecithin
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TAG Hydrolysis
TAG Hydrolysis
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Fat Storage
Fat Storage
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Adipose Tissue Functions
Adipose Tissue Functions
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Protein Digestion Start
Protein Digestion Start
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Secretin Hormone
Secretin Hormone
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Maltase
Maltase
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Sucrase
Sucrase
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Lactase
Lactase
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Absorption of Monosaccharides
Absorption of Monosaccharides
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Gastric Lipase
Gastric Lipase
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Inactive precursors
Inactive precursors
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Protease
Protease
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Lipase
Lipase
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Activation of zymogens
Activation of zymogens
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α-amylase
α-amylase
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Carbohydrate digestion site
Carbohydrate digestion site
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Function of bile acids
Function of bile acids
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Mucosal cell digestion
Mucosal cell digestion
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Study Notes
Metabolism
- Metabolism: The sum of all chemical reactions in a cell or organism.
- Pathway: A series of biochemical reactions
- Catabolism: Breakdown of large nutrient molecules into smaller molecules with the concurrent production of energy. Catabolism is generally accompanied by a net release of energy.
- Anabolism: Production of biological macromolecules through biosynthesis. Anabolism requires a net input of chemical energy.
- Catabolic and anabolic pathways with the same end points are not simple reversals of each other. Each pathway must be thermodynamically favorable in its own direction.
- Metabolic pathways are regulated by several mechanisms, including control of enzyme concentration, enzyme activity, and enzyme compartmentation.
Overview of Metabolism
- Nutrients: Fats, polysaccharides, and proteins are involved in both catabolism and anabolism.
- Catabolism: Oxidative process that converts nutrients into energy-releasing products.
- Anabolism: Reductive process requiring energy input to produce biological macromolecules including proteins, lipids, and nucleic acids.
- Some nutrients and products of catabolism require reducing agents and energy.
Digestive System and Digestive Juices
- Digestion: The process by which food is broken down into components simple enough to be absorbed in the intestine.
- The mouth, stomach, and duodenum deal with the initial process of mixing ingested food and initiating digestion.
- The duodenum receives bile and pancreatic secretions through the common bile duct.
- The small intestine is the main digestive area (jejunum and ileum). Absorption is initiated in the jejunum and continues through the ileum.
- The large intestine (specifically the colon) is primarily involved in absorbing electrolytes and water.
Digestive System and Digestive Juices - Details
- Most digestive enzymes are secreted as inactive precursors (zymogens)
- Enzymes involved in digesting proteins are secreted as inactive zymogens. Activation occurs when released to the gut lumen
- Activation can also happen due to change in pH or by enzyme activation by other enzymes.
- Secretion and function of enzymes is similar in salivary glands, gastric mucosa, and pancreas
Digestion and Absorption of Carbohydrates
- Carbohydrate digestion begins in the mouth with salivary a-amylase hydrolyzing some a-glycosidic linkages.
- Little carbohydrate digestion occurs in the stomach due to food being swallowed quickly.
- Stomach acidity inactivates the salivary amylase.
- The primary site for carbohydrate digestion is the small intestine.
- Pancreatic a-amylase further breaks down polysaccharides into disaccharides, which are then hydrolyzed by enzymes (maltase, sucrase, lactase) on the surface of the intestinal mucosal cells into monosaccharides.
- Monosaccharides (glucose, fructose, galactose) are absorbed by active transport into intestinal lining cells, and then enter the bloodstream.
- Galactose and fructose are converted to glucose intermediates in the liver prior to entering glycolysis.
- Glucose may be converted to glycogen for storage in the liver or tissues, oxidized for energy production or converted to fat.
Digestion and Absorption of Lipids
- Dietary lipids are mainly triacylglycerols (TAGs).
- Salivary enzymes have no effect on lipids in the mouth.
- In the stomach, TAGs are physically broken down into smaller globules. Gastric lipases start the hydrolysis of TAGs ( ~ 10%).
- Bile salts emulsify fat globules in the small intestine.
- Pancreatic lipases further hydrolyze TAGs producing fatty acids and monoacylglycerols.
- These products form micelles, which are absorbed into intestinal cells.
- Inside the cells, the products are reassembled into TAGs, packaged with cholesterol and phospholipids into chylomicrons for transport through the lymphatic system to the bloodstream.
Digestion and Absorption of Proteins
- Protein digestion begins in the stomach.
- HCI denatures proteins and activates pepsinogen to pepsin.
- Pepsin hydrolyzes peptide bonds.
- Large polypeptides pass from the stomach to the small intestine where additional enzymes (trypsin, chymotrypsin, carboxypeptidase, aminopeptidase) hydrolyze peptides further into oligopeptides and amino acids.
- Amino acids are absorbed into the bloodstream via active transport.
Summary of Intermediary Metabolism (Anabolism & Catabolism)
- Anabolism (reduction): Synthesis of simple organic compounds from inorganic components like CO2 and H2O.
- Catabolism (oxidation): Conversion of carbon in metabolic fuels to an activated 2-carbon fragment (acetyl-CoA).
- Catabolism is usually accompanied by a net release of energy.
- Anabolism typically requires a net input of energy.
- Metabolic pathways have intermediate steps which are often reversible in vivo but some are not and these irreversible steps are important regulatory points in the pathway.
- The activity of many metabolic pathways is controlled by multiple factors inside and outside the cell.
Cellular Respiration (Oxidation of Acetyl-CoA)
- The citric acid cycle is a key part of cellular respiration.
- Cellular respiration takes place in the mitochondria.
- This process includes glycolysis, a key component before entering the citric acid cycle, converting glucose to pyruvate and capturing a small amount of energy
- Intermediate reactions occur before full oxidation and the generation of ATP via the electron transport chain and an associated process--oxidative phosphorylation.
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Description
Test your knowledge on metabolism with this quiz, focusing on catabolism and anabolism. Explore biochemical pathways, nutrient roles, and the regulation of metabolic processes. Perfect for students learning about cellular biology.