Podcast
Questions and Answers
What is the process of forming new glucose from non-carbohydrate substrates called?
What is the process of forming new glucose from non-carbohydrate substrates called?
Which hormone is responsible for stimulating the breakdown of glycogen?
Which hormone is responsible for stimulating the breakdown of glycogen?
What is the process of converting acetyl-CoA to fatty acids called?
What is the process of converting acetyl-CoA to fatty acids called?
What is the primary role of insulin in metabolic processes?
What is the primary role of insulin in metabolic processes?
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The breakdown of glucose into pyruvate or lactate is known as what process?
The breakdown of glucose into pyruvate or lactate is known as what process?
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Which of these statements about HSL is correct?
Which of these statements about HSL is correct?
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Which of the following is NOT an effect of insulin on skeletal muscle?
Which of the following is NOT an effect of insulin on skeletal muscle?
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What is the primary role of insulin in the liver?
What is the primary role of insulin in the liver?
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Which of the following events directly triggers insulin release from beta cells?
Which of the following events directly triggers insulin release from beta cells?
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Which of the following inhibits insulin secretion?
Which of the following inhibits insulin secretion?
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What is the role of GIP (Gastric Inhibitory Peptide) in regulating insulin secretion?
What is the role of GIP (Gastric Inhibitory Peptide) in regulating insulin secretion?
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Which of these is NOT a direct action of Growth Hormone (GH)?
Which of these is NOT a direct action of Growth Hormone (GH)?
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Which of the following is an effect of low Growth Hormone levels?
Which of the following is an effect of low Growth Hormone levels?
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What is the main characteristic that differentiates catabolic hormones from anabolic hormones?
What is the main characteristic that differentiates catabolic hormones from anabolic hormones?
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Which hormone is primarily involved in regulating blood glucose levels during fasting?
Which hormone is primarily involved in regulating blood glucose levels during fasting?
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Which of the following is not a factor that stimulates glucagon secretion?
Which of the following is not a factor that stimulates glucagon secretion?
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What is the primary effect of glucagon on liver cells?
What is the primary effect of glucagon on liver cells?
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Which hormone is primarily responsible for regulating insulin and glucagon secretion?
Which hormone is primarily responsible for regulating insulin and glucagon secretion?
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Which of the following hormones is NOT associated with increasing plasma glucose levels?
Which of the following hormones is NOT associated with increasing plasma glucose levels?
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Which of the following hormones is directly involved in increasing glucose production by the liver?
Which of the following hormones is directly involved in increasing glucose production by the liver?
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What is the primary effect of glucagon on adipose tissue?
What is the primary effect of glucagon on adipose tissue?
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Which pancreatic cell type produces insulin?
Which pancreatic cell type produces insulin?
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Which of the following hormones is not involved in the combined catabolic effects during fasting?
Which of the following hormones is not involved in the combined catabolic effects during fasting?
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What is the precursor molecule for insulin synthesis?
What is the precursor molecule for insulin synthesis?
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What is the primary function of C-peptide?
What is the primary function of C-peptide?
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Which of the following is a characteristic of cortisol's action on glucose metabolism?
Which of the following is a characteristic of cortisol's action on glucose metabolism?
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Which of the following is not a common symptom of Cushing's Syndrome, a condition of cortisol excess?
Which of the following is not a common symptom of Cushing's Syndrome, a condition of cortisol excess?
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Which of the following is NOT a rapid action of insulin?
Which of the following is NOT a rapid action of insulin?
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Which enzyme is activated by insulin to facilitate glucose entry into cells?
Which enzyme is activated by insulin to facilitate glucose entry into cells?
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Which of the following is a characteristic of Addison's Disease, a condition of cortisol deficiency?
Which of the following is a characteristic of Addison's Disease, a condition of cortisol deficiency?
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What is the primary role of beta-2 receptors in the body in response to epinephrine?
What is the primary role of beta-2 receptors in the body in response to epinephrine?
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Which of the following is NOT a stimulus for insulin release?
Which of the following is NOT a stimulus for insulin release?
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What is the primary effect of insulin on liver cells?
What is the primary effect of insulin on liver cells?
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Epinephrine and glucagon both stimulate glycogenolysis. How are their actions different?
Epinephrine and glucagon both stimulate glycogenolysis. How are their actions different?
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Which hormone is directly responsible for the breakdown of triglycerides in adipose tissue?
Which hormone is directly responsible for the breakdown of triglycerides in adipose tissue?
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Which of the following hormones is primarily responsible for increasing blood glucose levels during fasting?
Which of the following hormones is primarily responsible for increasing blood glucose levels during fasting?
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Which of the following hormones is not produced by the pancreas?
Which of the following hormones is not produced by the pancreas?
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Which two hormones are primarily responsible for the breakdown of glycogen in the liver?
Which two hormones are primarily responsible for the breakdown of glycogen in the liver?
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Which hormone promotes protein synthesis in skeletal muscle?
Which hormone promotes protein synthesis in skeletal muscle?
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Cortisol's effect on glucose metabolism is primarily to:
Cortisol's effect on glucose metabolism is primarily to:
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Which of the following is not a consequence of cortisol excess (Cushing's syndrome)?
Which of the following is not a consequence of cortisol excess (Cushing's syndrome)?
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Which hormone is secreted from beta cells and helps regulate glucose levels by slowing gastric emptying and increasing satiety?
Which hormone is secreted from beta cells and helps regulate glucose levels by slowing gastric emptying and increasing satiety?
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Epinephrine's action on the pancreas is to:
Epinephrine's action on the pancreas is to:
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Which hormone produced by adipose tissue is involved in regulating insulin sensitivity and glucose levels?
Which hormone produced by adipose tissue is involved in regulating insulin sensitivity and glucose levels?
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Which hormone is primarily responsible for regulating metabolic rate and overall metabolism?
Which hormone is primarily responsible for regulating metabolic rate and overall metabolism?
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Which of the following is not a factor that stimulates epinephrine release?
Which of the following is not a factor that stimulates epinephrine release?
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What is the primary effect of glucagon during the fasting state?
What is the primary effect of glucagon during the fasting state?
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What is the primary role of insulin in the fed state?
What is the primary role of insulin in the fed state?
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Which hormone is primarily elevated during extended fasting?
Which hormone is primarily elevated during extended fasting?
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What is the primary role of ketones in the body during starvation?
What is the primary role of ketones in the body during starvation?
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Which of the following is NOT a symptom of diabetes?
Which of the following is NOT a symptom of diabetes?
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What is the primary difference between Type 1 and Type 2 diabetes?
What is the primary difference between Type 1 and Type 2 diabetes?
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Which of the following is a diagnostic criterion for diabetes based on a fasting plasma glucose level?
Which of the following is a diagnostic criterion for diabetes based on a fasting plasma glucose level?
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What is the primary cause of Type 1 diabetes?
What is the primary cause of Type 1 diabetes?
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What is the primary characteristic of Type II diabetes?
What is the primary characteristic of Type II diabetes?
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Which of the following is a hallmark symptom of diabetic ketoacidosis?
Which of the following is a hallmark symptom of diabetic ketoacidosis?
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What does an A1C test measure?
What does an A1C test measure?
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Which hormone is NOT involved in the metabolic response to fasting?
Which hormone is NOT involved in the metabolic response to fasting?
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What is the function of growth hormone during a fasting state?
What is the function of growth hormone during a fasting state?
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Which of these is NOT a common autoantibody found in individuals with Type 1 diabetes?
Which of these is NOT a common autoantibody found in individuals with Type 1 diabetes?
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Which of these is a characteristic of gestational diabetes?
Which of these is a characteristic of gestational diabetes?
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What is the primary factor contributing to the development of Type II diabetes in children?
What is the primary factor contributing to the development of Type II diabetes in children?
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What is considered a desirable level for total cholesterol?
What is considered a desirable level for total cholesterol?
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Which level of LDL cholesterol is classified as high?
Which level of LDL cholesterol is classified as high?
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Which factor is known to decrease HDL cholesterol levels?
Which factor is known to decrease HDL cholesterol levels?
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What is the normal range for Thyroid-Stimulating Hormone (TSH)?
What is the normal range for Thyroid-Stimulating Hormone (TSH)?
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What hormone is primarily secreted by the thyroid gland?
What hormone is primarily secreted by the thyroid gland?
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An increased level of TSH indicates which condition?
An increased level of TSH indicates which condition?
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What is the expected outcome of a Dexamethasone Suppression Test in a healthy individual?
What is the expected outcome of a Dexamethasone Suppression Test in a healthy individual?
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What is the normal morning range for cortisol levels?
What is the normal morning range for cortisol levels?
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What effect does cosyntropin have during the ACTH Stimulation Test in healthy individuals?
What effect does cosyntropin have during the ACTH Stimulation Test in healthy individuals?
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Which condition is suggested by cortisol levels greater than 5 mcg/dL after a Dexamethasone Suppression Test?
Which condition is suggested by cortisol levels greater than 5 mcg/dL after a Dexamethasone Suppression Test?
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What is a consequence of insulin deficiency in diabetic ketoacidosis?
What is a consequence of insulin deficiency in diabetic ketoacidosis?
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Which statement accurately describes the role of SGLT2 in glucose metabolism?
Which statement accurately describes the role of SGLT2 in glucose metabolism?
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Which hormone is responsible for breaking down glycogen in the liver?
Which hormone is responsible for breaking down glycogen in the liver?
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What might excessive glucose in the urine indicate?
What might excessive glucose in the urine indicate?
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What is a common symptom of diabetes related to excessive thirst?
What is a common symptom of diabetes related to excessive thirst?
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Which complication of diabetes is characterized by eye damage that can lead to blindness?
Which complication of diabetes is characterized by eye damage that can lead to blindness?
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Which of the following is associated with increased LDL levels in diabetic patients?
Which of the following is associated with increased LDL levels in diabetic patients?
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What is one effect of cortisol in diabetic conditions?
What is one effect of cortisol in diabetic conditions?
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Which mechanism contributes to increased reactive oxygen species (ROS) in diabetes?
Which mechanism contributes to increased reactive oxygen species (ROS) in diabetes?
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What is the primary reason for polydipsia in diabetes?
What is the primary reason for polydipsia in diabetes?
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What condition is most likely to cause severe metabolic acidosis in diabetes?
What condition is most likely to cause severe metabolic acidosis in diabetes?
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Which of the following is not a symptom commonly associated with diabetes?
Which of the following is not a symptom commonly associated with diabetes?
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What role does GLUT4 play in glucose metabolism?
What role does GLUT4 play in glucose metabolism?
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Which of the following can lead to decreased peripheral glucose utilization?
Which of the following can lead to decreased peripheral glucose utilization?
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What is the major effect of decreased insulin in relation to glucose metabolism?
What is the major effect of decreased insulin in relation to glucose metabolism?
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Which ketone form is primarily produced from fatty acids during ketogenesis?
Which ketone form is primarily produced from fatty acids during ketogenesis?
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What role does epinephrine play in glucose metabolism under stress?
What role does epinephrine play in glucose metabolism under stress?
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Which of the following is a symptom of hyperglycemia?
Which of the following is a symptom of hyperglycemia?
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What blood glucose level is typically considered hypoglycemic?
What blood glucose level is typically considered hypoglycemic?
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What causes the fruity smell in the breath of patients with diabetic ketoacidosis?
What causes the fruity smell in the breath of patients with diabetic ketoacidosis?
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Which process is stimulated by insulin?
Which process is stimulated by insulin?
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What is the normal fasting glucose range considered healthy?
What is the normal fasting glucose range considered healthy?
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What is the relationship between LDL levels and coronary heart disease risk?
What is the relationship between LDL levels and coronary heart disease risk?
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What can result from overdosing on insulin?
What can result from overdosing on insulin?
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What is the main purpose of measuring Hemoglobin A1c (HbA1c)?
What is the main purpose of measuring Hemoglobin A1c (HbA1c)?
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Which scenario can impair gluconeogenesis, increasing the risk of hypoglycemia?
Which scenario can impair gluconeogenesis, increasing the risk of hypoglycemia?
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What happens to glucose levels during osmotic diuresis?
What happens to glucose levels during osmotic diuresis?
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What are common symptoms of repeated hypoglycemic episodes?
What are common symptoms of repeated hypoglycemic episodes?
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Which of these is a characteristic of Type II diabetes?
Which of these is a characteristic of Type II diabetes?
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What is a common complication associated with gestational diabetes for babies?
What is a common complication associated with gestational diabetes for babies?
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What is the typical time frame for testing for gestational diabetes?
What is the typical time frame for testing for gestational diabetes?
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Which of these is NOT a risk factor for gestational diabetes?
Which of these is NOT a risk factor for gestational diabetes?
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What is the most likely reason for the rise in gestational diabetes?
What is the most likely reason for the rise in gestational diabetes?
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Which of these is a complication for mothers with gestational diabetes?
Which of these is a complication for mothers with gestational diabetes?
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What is the most common method used to diagnose gestational diabetes?
What is the most common method used to diagnose gestational diabetes?
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Which of these scenarios would most strongly suggest a patient has Type II diabetes?
Which of these scenarios would most strongly suggest a patient has Type II diabetes?
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What effect does untreated diabetes have on the liver?
What effect does untreated diabetes have on the liver?
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Why might a patient with Type II diabetes have elevated triglyceride levels?
Why might a patient with Type II diabetes have elevated triglyceride levels?
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What is a potential consequence of a lack of insulin regulation on amino acid metabolism?
What is a potential consequence of a lack of insulin regulation on amino acid metabolism?
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Which component of blood lipids is considered 'good cholesterol'?
Which component of blood lipids is considered 'good cholesterol'?
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What is a major factor contributing to insulin resistance in Type II diabetes?
What is a major factor contributing to insulin resistance in Type II diabetes?
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What does the presence of albumin in the urine indicate in a patient with Type II diabetes?
What does the presence of albumin in the urine indicate in a patient with Type II diabetes?
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What is the primary function of the GLUT-4 transporter?
What is the primary function of the GLUT-4 transporter?
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Flashcards
Glycogenesis
Glycogenesis
Process of glycogen formation in the body.
Glycogenolysis
Glycogenolysis
Process of breaking down glycogen into glucose.
Glycolysis
Glycolysis
The breakdown of glucose into pyruvate or lactate.
Gluconeogenesis
Gluconeogenesis
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Lipogenesis
Lipogenesis
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Insulin
Insulin
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Glucagon
Glucagon
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Amylin
Amylin
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Somatostatin (SST)
Somatostatin (SST)
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Growth Hormone (GH)
Growth Hormone (GH)
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Epinephrine
Epinephrine
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Cortisol
Cortisol
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GLP-1
GLP-1
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Leptin
Leptin
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T3 and T4
T3 and T4
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Anabolic Hormones
Anabolic Hormones
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Catabolic Hormones
Catabolic Hormones
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Insulin Mechanism
Insulin Mechanism
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Insulin Release Stimuli
Insulin Release Stimuli
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Insulin in Fat Tissue
Insulin in Fat Tissue
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Lipolysis
Lipolysis
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Glucagon Action on Liver
Glucagon Action on Liver
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Factors Stimulating Glucagon Secretion
Factors Stimulating Glucagon Secretion
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Inhibitors of Glucagon Secretion
Inhibitors of Glucagon Secretion
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Epinephrine Effects on Blood Pressure
Epinephrine Effects on Blood Pressure
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Combined Catabolic Effects
Combined Catabolic Effects
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Cushing's Syndrome
Cushing's Syndrome
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HSL Function
HSL Function
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Insulin in Muscle
Insulin in Muscle
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Addison's Disease
Addison's Disease
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Insulin in Liver
Insulin in Liver
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Protein Breakdown
Protein Breakdown
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Glucose Insulin Secretion
Glucose Insulin Secretion
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Hormone Sensitive Lipase
Hormone Sensitive Lipase
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Insulin Secretagogues
Insulin Secretagogues
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GIP
GIP
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Growth Hormone Effects
Growth Hormone Effects
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Stimuli for Growth Hormone
Stimuli for Growth Hormone
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Fed State
Fed State
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Effect of Insulin
Effect of Insulin
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Glucagon in Fed State
Glucagon in Fed State
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Net Effect of Fasting
Net Effect of Fasting
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Epinephrine Role in Fasting
Epinephrine Role in Fasting
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Growth Hormone in Fasting
Growth Hormone in Fasting
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Cortisol in Extended Fasting
Cortisol in Extended Fasting
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Starvation Effects
Starvation Effects
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A1C Test
A1C Test
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Diabetes Diagnosis Criteria
Diabetes Diagnosis Criteria
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Type I Diabetes
Type I Diabetes
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Type II Diabetes
Type II Diabetes
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Diabetes Symptoms
Diabetes Symptoms
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Oral Glucose Tolerance Test (OGTT)
Oral Glucose Tolerance Test (OGTT)
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Ketoacidosis
Ketoacidosis
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Catabolic Function
Catabolic Function
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Ketone Production
Ketone Production
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SGLT1
SGLT1
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SGLT2
SGLT2
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Diabetic Glucosuria
Diabetic Glucosuria
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GLUT2
GLUT2
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GLUT4
GLUT4
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Diabetic Neuropathy
Diabetic Neuropathy
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Diabetic Retinopathy
Diabetic Retinopathy
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Reactive Oxygen Species (ROS)
Reactive Oxygen Species (ROS)
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Advanced Glycation End Products (AGEs)
Advanced Glycation End Products (AGEs)
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Diabetic Ketoacidosis (DKA)
Diabetic Ketoacidosis (DKA)
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Total Cholesterol Levels
Total Cholesterol Levels
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LDL Cholesterol Levels
LDL Cholesterol Levels
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Fasting Triglycerides Levels
Fasting Triglycerides Levels
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Non-HDL Cholesterol Levels
Non-HDL Cholesterol Levels
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HDL Cholesterol Levels
HDL Cholesterol Levels
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Thyroid-Stimulating Hormone (TSH)
Thyroid-Stimulating Hormone (TSH)
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Thyroxine (T4) Levels
Thyroxine (T4) Levels
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Triiodothyronine (T3) Levels
Triiodothyronine (T3) Levels
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Normal Cortisol Levels
Normal Cortisol Levels
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Dexamethasone Suppression Test
Dexamethasone Suppression Test
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Catecholamines
Catecholamines
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Ketogenesis
Ketogenesis
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Hypoglycemia Symptoms
Hypoglycemia Symptoms
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Hemoglobin A1c (HbA1c)
Hemoglobin A1c (HbA1c)
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Fasting Glucose
Fasting Glucose
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Frequent Urination (Polyuria)
Frequent Urination (Polyuria)
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Acetoacetate
Acetoacetate
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Ketoacidosis Symptoms
Ketoacidosis Symptoms
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Insulin Resistance
Insulin Resistance
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Beta Cell Function
Beta Cell Function
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GLUT-2 Transporter
GLUT-2 Transporter
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First Phase Insulin Secretion
First Phase Insulin Secretion
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Second Phase Insulin Secretion
Second Phase Insulin Secretion
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Obesity's Role in Diabetes
Obesity's Role in Diabetes
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Gestational Diabetes
Gestational Diabetes
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Macrosomia
Macrosomia
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C-peptide Levels
C-peptide Levels
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Complications of Uncontrolled Diabetes
Complications of Uncontrolled Diabetes
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Hyperinsulinemia
Hyperinsulinemia
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Elevated Free Fatty Acids
Elevated Free Fatty Acids
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Study Notes
Glucose and Lipid Metabolism (Part 1)
- Hormones regulating metabolism: Insulin, glucagon, somatostatin, epinephrine, growth hormone, cortisol, gut hormones (GI), and nutrients all play crucial roles.
- Insulin's role: Promotes glucose, lipid, and protein storage. Acts anabolically. Insulin stimulates glycogenesis, lipogenesis, and protein synthesis, decreasing glucose, amino acids, and fatty acids
- Glucagon's role: Promotes glucose production, acting catabolically. Triggers glycogenolysis and gluconeogenesis. Also stimulates lipolysis.
- Somatostatin: Regulates insulin and glucagon (inhibits them).
- Epinephrine: Increases glucose production and lipolysis.
- Growth Hormone's role (GH): Increases glucose and protein production (anabolic, primarily protein), and regulates other functions such as sodium retention and lipolysis.
- Cortisol's role: Increases glucose production, also increases breakdown of protein and fat. Catabolic effects.
- Gut hormones (GI): Alters insulin secretion and enhance glucose metabolism.
- Insulin release: Stimulated by increased plasma glucose and amino acid levels.
- Insulin mechanism of action: Activates PI3 kinase, which is needed to insert GLUT4 transporters into cell membranes, allowing glucose entry. Also involved in protein synthesis and glycogen storage.
- Fast action of insulin: Facilitates GLUT4 insertion and potassium uptake into cells
- Intermediate action of insulin: Stimulates protein synthesis and glycolytic enzymes. Promotes glycogen synthesis
- Slow action of insulin: Inhibits phosphorylase and gluconeogenic enzymes, increases mRNA for lipogenic enzymes.
- Insulin actions on different tissues: Insulin impacts various organs like liver, fat tissue, and skeletal muscle, driving anabolic reactions.
- Liver: Stimulates glucose uptake, glycolysis, glycogen synthesis, lipid synthesis, and protein synthesis.
- Fat tissue: Enhances triglyceride synthesis for storage.
- Skeletal muscle: Stimulates protein synthesis, boosts glucose and glycogen uptake, and decreases protein breakdown. Also promotes ketone and potassium uptake.
- Amylin: Secreted by beta cells, inhibits glucagon, and decreases glucose.
Glucose and Lipid Metabolism (Part 2)
- Growth Hormone (GH) details: Enhances protein synthesis, reduces insulin sensitivity and promotes lipolysis. A key anabolic hormone in protein synthesis, it is distinct from insulin's broader anabolic effects on glycogen and triglycerides.
- Insulin-like growth factor 1 (IGF-1): Promotes protein synthesis, anti-lipolytic (prevents fat breakdown) and related effects. Part of GH interaction.
- Growth hormone actions: Direct and indirect (through IGF-1) promotion of protein synthesis. Effects on bone growth and bone mass.
- Glucagon secretion: Stimulated by low blood glucose, protein meals, GI hormones, stress, exercise, infection, and fasting.
- Glucagon actions: Promotes glycogenolysis in the liver and gluconeogenesis. Stimulates lipolysis in fat tissue. Inhibits glucose metabolism.
- Epinephrine actions: Increased glycogenolysis and gluconeogenesis (in both liver and muscle) and increased blood glucose levels, and lipolysis.
- Cortisol actions: Stimulates gluconeogenesis, protein breakdown and lipolysis.
Glucose and Lipid Metabolism (Part 3)
- Hormonal changes in different metabolic states: Clear patterns of hormonal response to fed, fasting, and other states exist.
- Combined catabolic effect (glucagon, epinephrine, cortisol) during fasting: Glucagon and epinephrine have a rapid effect, while the effects of cortisol are slower and have synergistic interaction with the previous two.
- Diabetic states: Detailed overview of Type 1 Diabetes, Type 2 Diabetes and gestational diabetes, including risks, complications, differences in symptoms and progression.
- Glucose transporters: SGLT1 and SGLT2 (kidneys) and GLUT2 and GLUT4 (various tissues) detailed, emphasizing their roles in glucose uptake, reabsorption.
- Types of Diabetes: Important overview of Type I and Type 2 Diabetes: differences in symptoms, progression, and insulin dependence.
- Hormones that increase glucose levels: Glucagon along with epinephrine, thyroid hormones, cortisol and growth hormone. Effects on cellular functions and pathways highlighted.
Diabetes Diagnosis and Management
- Diabetes diagnosis criteria: Methods used to diagnose diabetes, including fasting plasma glucose, 2-hour postprandial glucose, random plasma glucose, and HbA1c (glycated hemoglobin) levels.
- Oral Glucose Tolerance Test (OGTT): Details of the test to assess glucose tolerance over time.
- Diabetes classification: Categorization of diabetes into Type 1, Type 2, Gestational, and other types.
- Type 1 Diabetes: Autoimmune disorder, abrupt/rapid onset, generally lean body type and early onset.
- Type 2 Diabetes: Insulin resistance, gradual onset, typically adult onset and associated with obesity, or poor diet.
- Gestational Diabetes: Glucose intolerance during pregnancy, increasing incidence related to societal obesity trends.
- Symptoms and outcomes: Description of various stages and symptoms of hypoglycemia and hyperglycemia, and detailed description of diabetes complications like long-term health implications.
Markers of Endocrine Function
- Glucose levels: Normal ranges and importance in diagnosing and monitoring health.
- Hemoglobin A1c (HbA1c): Reflects average blood glucose over months.
- Lipid panel: Detailed information on total cholesterol, LDL, HDL, triglycerides, and significance in cardiovascular health.
- Thyroid markers: Thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) levels, roles in metabolism, and associated pathologies.
- Adrenal gland markers: Cortisol, ACTH, and related tests (e.g., Dexamethasone suppression test) for diagnosing and managing adrenal disorders.
Studying That Suits You
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Description
Test your knowledge on metabolic processes and the hormones that regulate them. This quiz covers topics such as glucose formation, hormonal actions, and the roles of specific hormones like insulin and Growth Hormone. Assess your understanding of how these factors influence metabolism.