Metabolism and Hormones Quiz
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Questions and Answers

What is the process of forming new glucose from non-carbohydrate substrates called?

  • Glycogenolysis
  • Glycogenesis
  • Glycolysis
  • Gluconeogenesis (correct)
  • Which hormone is responsible for stimulating the breakdown of glycogen?

  • Glucagon (correct)
  • Epinephrine
  • Insulin
  • Somatostatin
  • What is the process of converting acetyl-CoA to fatty acids called?

  • Glycolysis
  • Adipogenesis
  • Lipolysis
  • Lipogenesis (correct)
  • What is the primary role of insulin in metabolic processes?

    <p>Promoting the uptake of glucose by cells (D)</p> Signup and view all the answers

    The breakdown of glucose into pyruvate or lactate is known as what process?

    <p>Glycolysis (A)</p> Signup and view all the answers

    Which of these statements about HSL is correct?

    <p>HSL breaks down triglycerides into free fatty acids and glycerol. (B)</p> Signup and view all the answers

    Which of the following is NOT an effect of insulin on skeletal muscle?

    <p>Increases gluconeogenesis. (A)</p> Signup and view all the answers

    What is the primary role of insulin in the liver?

    <p>Promote protein and lipid synthesis. (C)</p> Signup and view all the answers

    Which of the following events directly triggers insulin release from beta cells?

    <p>Calcium influx into the beta cell. (A)</p> Signup and view all the answers

    Which of the following inhibits insulin secretion?

    <p>Somatostatin. (D)</p> Signup and view all the answers

    What is the role of GIP (Gastric Inhibitory Peptide) in regulating insulin secretion?

    <p>GIP stimulates insulin secretion in the presence of glucose. (C)</p> Signup and view all the answers

    Which of these is NOT a direct action of Growth Hormone (GH)?

    <p>Increases glycogen synthesis. (B)</p> Signup and view all the answers

    Which of the following is an effect of low Growth Hormone levels?

    <p>Smaller protein mass. (D)</p> Signup and view all the answers

    What is the main characteristic that differentiates catabolic hormones from anabolic hormones?

    <p>Catabolic hormones promote the breakdown of molecules. (D)</p> Signup and view all the answers

    Which hormone is primarily involved in regulating blood glucose levels during fasting?

    <p>Glucagon. (B)</p> Signup and view all the answers

    Which of the following is not a factor that stimulates glucagon secretion?

    <p>Glucose (A)</p> Signup and view all the answers

    What is the primary effect of glucagon on liver cells?

    <p>Stimulates glycogenolysis and gluconeogenesis (D)</p> Signup and view all the answers

    Which hormone is primarily responsible for regulating insulin and glucagon secretion?

    <p>Somatostatin (D)</p> Signup and view all the answers

    Which of the following hormones is NOT associated with increasing plasma glucose levels?

    <p>Insulin (C)</p> Signup and view all the answers

    Which of the following hormones is directly involved in increasing glucose production by the liver?

    <p>Epinephrine (B)</p> Signup and view all the answers

    What is the primary effect of glucagon on adipose tissue?

    <p>Stimulates lipolysis (C)</p> Signup and view all the answers

    Which pancreatic cell type produces insulin?

    <p>Beta cells (B)</p> Signup and view all the answers

    Which of the following hormones is not involved in the combined catabolic effects during fasting?

    <p>Insulin (B)</p> Signup and view all the answers

    What is the precursor molecule for insulin synthesis?

    <p>Proinsulin (A)</p> Signup and view all the answers

    What is the primary function of C-peptide?

    <p>Serving as a marker for insulin levels (C)</p> Signup and view all the answers

    Which of the following is a characteristic of cortisol's action on glucose metabolism?

    <p>Enhances the effects of glucagon and epinephrine on gluconeogensis (B)</p> Signup and view all the answers

    Which of the following is not a common symptom of Cushing's Syndrome, a condition of cortisol excess?

    <p>Hypoglycemia (A)</p> Signup and view all the answers

    Which of the following is NOT a rapid action of insulin?

    <p>Activation of glycolytic enzymes (A)</p> Signup and view all the answers

    Which enzyme is activated by insulin to facilitate glucose entry into cells?

    <p>PI3 kinase (D)</p> Signup and view all the answers

    Which of the following is a characteristic of Addison's Disease, a condition of cortisol deficiency?

    <p>Hyperpigmentation of the skin (A)</p> Signup and view all the answers

    What is the primary role of beta-2 receptors in the body in response to epinephrine?

    <p>Glycogenolysis (A)</p> Signup and view all the answers

    Which of the following is NOT a stimulus for insulin release?

    <p>Decreased blood glucose levels (A)</p> Signup and view all the answers

    What is the primary effect of insulin on liver cells?

    <p>Promotion of glucose uptake and storage (D)</p> Signup and view all the answers

    Epinephrine and glucagon both stimulate glycogenolysis. How are their actions different?

    <p>Glucagon only acts on the liver, while epinephrine acts on both the liver and muscle. (D)</p> Signup and view all the answers

    Which hormone is directly responsible for the breakdown of triglycerides in adipose tissue?

    <p>Hormone-sensitive lipase (HSL) (B)</p> Signup and view all the answers

    Which of the following hormones is primarily responsible for increasing blood glucose levels during fasting?

    <p>Glucagon (D)</p> Signup and view all the answers

    Which of the following hormones is not produced by the pancreas?

    <p>Epinephrine (B)</p> Signup and view all the answers

    Which two hormones are primarily responsible for the breakdown of glycogen in the liver?

    <p>Glucagon and epinephrine (B)</p> Signup and view all the answers

    Which hormone promotes protein synthesis in skeletal muscle?

    <p>Insulin (A)</p> Signup and view all the answers

    Cortisol's effect on glucose metabolism is primarily to:

    <p>Enhance the effects of glucagon and epinephrine on gluconeogenesis (C)</p> Signup and view all the answers

    Which of the following is not a consequence of cortisol excess (Cushing's syndrome)?

    <p>Increased bone density (A)</p> Signup and view all the answers

    Which hormone is secreted from beta cells and helps regulate glucose levels by slowing gastric emptying and increasing satiety?

    <p>Amylin (A)</p> Signup and view all the answers

    Epinephrine's action on the pancreas is to:

    <p>Stimulate glucagon secretion (C)</p> Signup and view all the answers

    Which hormone produced by adipose tissue is involved in regulating insulin sensitivity and glucose levels?

    <p>All of the above (D)</p> Signup and view all the answers

    Which hormone is primarily responsible for regulating metabolic rate and overall metabolism?

    <p>Thyroid hormones (T3 and T4) (A)</p> Signup and view all the answers

    Which of the following is not a factor that stimulates epinephrine release?

    <p>Hyperglycemia (D)</p> Signup and view all the answers

    What is the primary effect of glucagon during the fasting state?

    <p>Stimulates the breakdown of stored glycogen and gluconeogenesis (D)</p> Signup and view all the answers

    What is the primary role of insulin in the fed state?

    <p>Promotes the uptake and storage of glucose, protein, and fat (C)</p> Signup and view all the answers

    Which hormone is primarily elevated during extended fasting?

    <p>Cortisol (B)</p> Signup and view all the answers

    What is the primary role of ketones in the body during starvation?

    <p>Serve as an alternative fuel source for the brain (A)</p> Signup and view all the answers

    Which of the following is NOT a symptom of diabetes?

    <p>Increased appetite (B)</p> Signup and view all the answers

    What is the primary difference between Type 1 and Type 2 diabetes?

    <p>Type 1 is caused by insulin deficiency, while Type 2 is caused by insulin insensitivity (A)</p> Signup and view all the answers

    Which of the following is a diagnostic criterion for diabetes based on a fasting plasma glucose level?

    <p>Over 126 mg/dL (B)</p> Signup and view all the answers

    What is the primary cause of Type 1 diabetes?

    <p>Autoimmune destruction of beta cells in the pancreas (A)</p> Signup and view all the answers

    What is the primary characteristic of Type II diabetes?

    <p>Insulin resistance due to factors like obesity and genetics (A)</p> Signup and view all the answers

    Which of the following is a hallmark symptom of diabetic ketoacidosis?

    <p>High levels of ketones in the blood and urine (B)</p> Signup and view all the answers

    What does an A1C test measure?

    <p>Average blood glucose levels over the past 3 months (A)</p> Signup and view all the answers

    Which hormone is NOT involved in the metabolic response to fasting?

    <p>Thyroid Hormone (A)</p> Signup and view all the answers

    What is the function of growth hormone during a fasting state?

    <p>Inhibit insulin secretion and promote protein synthesis (A)</p> Signup and view all the answers

    Which of these is NOT a common autoantibody found in individuals with Type 1 diabetes?

    <p>Antibodies to C-peptide (D)</p> Signup and view all the answers

    Which of these is a characteristic of gestational diabetes?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the primary factor contributing to the development of Type II diabetes in children?

    <p>Increasing prevalence of childhood obesity (D)</p> Signup and view all the answers

    What is considered a desirable level for total cholesterol?

    <p>Less than 200 mg/dL (B)</p> Signup and view all the answers

    Which level of LDL cholesterol is classified as high?

    <p>190 mg/dL or greater (D)</p> Signup and view all the answers

    Which factor is known to decrease HDL cholesterol levels?

    <p>Poorly controlled diabetes (D)</p> Signup and view all the answers

    What is the normal range for Thyroid-Stimulating Hormone (TSH)?

    <p>0.3 to 5 mIU/L (D)</p> Signup and view all the answers

    What hormone is primarily secreted by the thyroid gland?

    <p>T4 (D)</p> Signup and view all the answers

    An increased level of TSH indicates which condition?

    <p>Hypothyroidism (C)</p> Signup and view all the answers

    What is the expected outcome of a Dexamethasone Suppression Test in a healthy individual?

    <p>Suppression of cortisol production (A)</p> Signup and view all the answers

    What is the normal morning range for cortisol levels?

    <p>6 to 25 mcg/dL (B)</p> Signup and view all the answers

    What effect does cosyntropin have during the ACTH Stimulation Test in healthy individuals?

    <p>Stimulates cortisol secretion (D)</p> Signup and view all the answers

    Which condition is suggested by cortisol levels greater than 5 mcg/dL after a Dexamethasone Suppression Test?

    <p>Cushing syndrome (D)</p> Signup and view all the answers

    What is a consequence of insulin deficiency in diabetic ketoacidosis?

    <p>Increased ketone production (A)</p> Signup and view all the answers

    Which statement accurately describes the role of SGLT2 in glucose metabolism?

    <p>It helps excrete glucose during hyperglycemia. (C)</p> Signup and view all the answers

    Which hormone is responsible for breaking down glycogen in the liver?

    <p>Glucagon (C)</p> Signup and view all the answers

    What might excessive glucose in the urine indicate?

    <p>High blood glucose levels (A)</p> Signup and view all the answers

    What is a common symptom of diabetes related to excessive thirst?

    <p>Polydipsia (D)</p> Signup and view all the answers

    Which complication of diabetes is characterized by eye damage that can lead to blindness?

    <p>Diabetic retinopathy (A)</p> Signup and view all the answers

    Which of the following is associated with increased LDL levels in diabetic patients?

    <p>Accelerated atherosclerosis (D)</p> Signup and view all the answers

    What is one effect of cortisol in diabetic conditions?

    <p>Increased gluconeogenesis (A)</p> Signup and view all the answers

    Which mechanism contributes to increased reactive oxygen species (ROS) in diabetes?

    <p>Formation of sugar alcohols (D)</p> Signup and view all the answers

    What is the primary reason for polydipsia in diabetes?

    <p>Osmotic diuresis (A)</p> Signup and view all the answers

    What condition is most likely to cause severe metabolic acidosis in diabetes?

    <p>Ketoacidosis (C)</p> Signup and view all the answers

    Which of the following is not a symptom commonly associated with diabetes?

    <p>Weight gain (D)</p> Signup and view all the answers

    What role does GLUT4 play in glucose metabolism?

    <p>It facilitates insulin-dependent glucose entry into muscle cells. (D)</p> Signup and view all the answers

    Which of the following can lead to decreased peripheral glucose utilization?

    <p>Growth hormone (D)</p> Signup and view all the answers

    What is the major effect of decreased insulin in relation to glucose metabolism?

    <p>Decreased glucose uptake (C)</p> Signup and view all the answers

    Which ketone form is primarily produced from fatty acids during ketogenesis?

    <p>Beta-hydroxybutyrate (B)</p> Signup and view all the answers

    What role does epinephrine play in glucose metabolism under stress?

    <p>Accelerates glycogen breakdown (C)</p> Signup and view all the answers

    Which of the following is a symptom of hyperglycemia?

    <p>Excessive thirst (B)</p> Signup and view all the answers

    What blood glucose level is typically considered hypoglycemic?

    <p>Below 70 mg/dL (B)</p> Signup and view all the answers

    What causes the fruity smell in the breath of patients with diabetic ketoacidosis?

    <p>Accumulation of acetone (B)</p> Signup and view all the answers

    Which process is stimulated by insulin?

    <p>Glycogenesis (C)</p> Signup and view all the answers

    What is the normal fasting glucose range considered healthy?

    <p>70 to 99 mg/dL (A)</p> Signup and view all the answers

    What is the relationship between LDL levels and coronary heart disease risk?

    <p>Positive relationship (A)</p> Signup and view all the answers

    What can result from overdosing on insulin?

    <p>Hypoglycemia (C)</p> Signup and view all the answers

    What is the main purpose of measuring Hemoglobin A1c (HbA1c)?

    <p>To reflect average blood glucose levels over several months (C)</p> Signup and view all the answers

    Which scenario can impair gluconeogenesis, increasing the risk of hypoglycemia?

    <p>Alcohol consumption (D)</p> Signup and view all the answers

    What happens to glucose levels during osmotic diuresis?

    <p>Increase in glucose levels (C)</p> Signup and view all the answers

    What are common symptoms of repeated hypoglycemic episodes?

    <p>Impairment in recognizing hypoglycemic events (B)</p> Signup and view all the answers

    Which of these is a characteristic of Type II diabetes?

    <p>Insulin resistance (A)</p> Signup and view all the answers

    What is a common complication associated with gestational diabetes for babies?

    <p>Hypoglycemia (D)</p> Signup and view all the answers

    What is the typical time frame for testing for gestational diabetes?

    <p>Third trimester (D)</p> Signup and view all the answers

    Which of these is NOT a risk factor for gestational diabetes?

    <p>Low body mass index (BMI) (B)</p> Signup and view all the answers

    What is the most likely reason for the rise in gestational diabetes?

    <p>Increased rates of obesity and overweight (C)</p> Signup and view all the answers

    Which of these is a complication for mothers with gestational diabetes?

    <p>All of the above (D)</p> Signup and view all the answers

    What is the most common method used to diagnose gestational diabetes?

    <p>Oral glucose tolerance test (OGTT) (B)</p> Signup and view all the answers

    Which of these scenarios would most strongly suggest a patient has Type II diabetes?

    <p>An obese patient with a history of high blood pressure and a family history of diabetes. (C)</p> Signup and view all the answers

    What effect does untreated diabetes have on the liver?

    <p>Increased glucose production and decreased glycogen storage (B)</p> Signup and view all the answers

    Why might a patient with Type II diabetes have elevated triglyceride levels?

    <p>Increased breakdown of fats in adipose tissue (A)</p> Signup and view all the answers

    What is a potential consequence of a lack of insulin regulation on amino acid metabolism?

    <p>Increased amino acid conversion to glucose (A)</p> Signup and view all the answers

    Which component of blood lipids is considered 'good cholesterol'?

    <p>HDL (D)</p> Signup and view all the answers

    What is a major factor contributing to insulin resistance in Type II diabetes?

    <p>Excess weight and physical inactivity. (B)</p> Signup and view all the answers

    What does the presence of albumin in the urine indicate in a patient with Type II diabetes?

    <p>Kidney dysfunction (B)</p> Signup and view all the answers

    What is the primary function of the GLUT-4 transporter?

    <p>Transporting glucose into skeletal muscle cells (C)</p> Signup and view all the answers

    Flashcards

    Glycogenesis

    Process of glycogen formation in the body.

    Glycogenolysis

    Process of breaking down glycogen into glucose.

    Glycolysis

    The breakdown of glucose into pyruvate or lactate.

    Gluconeogenesis

    Generation of glucose from non-carbohydrate sources.

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    Lipogenesis

    Conversion of acetyl-CoA to fatty acids.

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    Insulin

    A hormone from the pancreas that regulates glucose and lipid storage.

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    Glucagon

    A hormone from the pancreas that promotes glucose production.

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    Amylin

    A hormone that inhibits glucagon and slows gastric emptying.

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    Somatostatin (SST)

    A hormone that inhibits insulin and glucagon secretion.

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    Growth Hormone (GH)

    A hormone that stimulates glucose production in the liver.

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    Epinephrine

    A hormone that increases glucose production and mobilizes energy in stress.

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    Cortisol

    A hormone that raises glucose levels during stress.

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    GLP-1

    A gut hormone that alters insulin secretion.

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    Leptin

    A hormone that regulates satiety and energy balance.

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    T3 and T4

    Thyroid hormones that regulate metabolism and metabolic rate.

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    Anabolic Hormones

    Hormones that promote storage forms: insulin and growth hormone.

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    Catabolic Hormones

    Hormones that break down larger molecules: glucagon, epinephrine, cortisol.

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    Insulin Mechanism

    Insulin promotes glucose uptake by activating GLUT4 transporters.

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    Insulin Release Stimuli

    Factors that trigger insulin secretion include glucose and amino acids.

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    Insulin in Fat Tissue

    Stimulates triglyceride synthesis and inhibits fat breakdown.

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    Lipolysis

    Breakdown of triglycerides into free fatty acids.

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    Glucagon Action on Liver

    Stimulates glycogenolysis and gluconeogenesis in the liver.

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    Factors Stimulating Glucagon Secretion

    Amino acids, GI hormones, cortisol, exercise, fasting.

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    Inhibitors of Glucagon Secretion

    Glucose, free fatty acids, ketones, insulin.

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    Epinephrine Effects on Blood Pressure

    Increases heart rate and vasoconstriction via beta-1 and alpha-1 receptors.

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    Combined Catabolic Effects

    Glucagon and epinephrine raise glucose; cortisol enhances and has slower effects.

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    Cushing's Syndrome

    Cortisol excess leading to hyperglycemia and poor wound healing.

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    HSL Function

    HSL breaks down triglycerides into free fatty acids and glycerol.

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    Insulin in Muscle

    Insulin increases amino acid and glucose uptake, promotes protein synthesis, and decreases protein breakdown.

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    Addison's Disease

    Cortisol deficiency causing hypoglycemia and low blood pressure.

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    Insulin in Liver

    Insulin promotes glycolysis, glycogen synthesis, and inhibits gluconeogenesis in the liver.

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    Protein Breakdown

    Cortisol promotes protein breakdown in muscle tissue.

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    Glucose Insulin Secretion

    Glucose stimulates insulin secretion through a series of steps starting from glycolysis in pancreatic beta cells.

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    Hormone Sensitive Lipase

    Enzyme activated by glucagon to promote fat breakdown.

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    Insulin Secretagogues

    Substances that stimulate insulin secretion include glucose, amino acids, and intestinal hormones like GIP and GLP-1.

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    GIP

    GIP is an intestinal hormone that stimulates insulin secretion when fat and glucose are present.

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    Growth Hormone Effects

    Growth hormone promotes sodium retention, lipolysis, and protein synthesis, while decreasing insulin sensitivity.

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    Stimuli for Growth Hormone

    Factors that stimulate GH secretion include hypoglycemia, exercise, and sleep.

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    Fed State

    Post-prandial phase when the body absorbs and stores nutrients.

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    Effect of Insulin

    Insulin promotes storage of glucose, protein, and fat following meals.

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    Glucagon in Fed State

    Increased glucagon secretion helps prevent hypoglycemia during the fed state.

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    Net Effect of Fasting

    Mobilization of stored fuel to provide energy when not eating.

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    Epinephrine Role in Fasting

    Increased epinephrine helps promote energy production during fasting.

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    Growth Hormone in Fasting

    Growth hormone increases during fasting to promote fat usage and limit insulin.

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    Cortisol in Extended Fasting

    Stimulates further energy mobilization and increases during extended fasting.

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    Starvation Effects

    During starvation, glucagon is suppressed, while epinephrine and growth hormone increase.

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    A1C Test

    A test that reflects average blood glucose levels over the past 2-3 months.

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    Diabetes Diagnosis Criteria

    Specific glucose levels used to diagnose diabetes type and status.

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    Type I Diabetes

    An autoimmune condition leading to near-zero insulin production primarily in youth.

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    Type II Diabetes

    Characterized by insulin insensitivity, often related to obesity.

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    Diabetes Symptoms

    Common symptoms include polyuria, polydipsia, and polyphagia.

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    Oral Glucose Tolerance Test (OGTT)

    Measures glucose response after consuming a glucose solution.

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    Ketoacidosis

    A serious complication of diabetes characterized by high ketone levels and blood acidity.

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    Catabolic Function

    Shift in metabolism from building up to breaking down substances, leading to increased energy release.

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    Ketone Production

    The process by which the liver produces ketones during low glucose availability; can lead to ketoacidosis.

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    SGLT1

    Sodium-glucose co-transporter in the small intestine, responsible for glucose absorption into the bloodstream.

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    SGLT2

    Sodium-glucose co-transporter in kidneys that reabsorbs glucose back into the blood.

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    Diabetic Glucosuria

    Condition where glucose is present in urine due to high blood sugar levels exceeding renal reabsorption capacity.

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    GLUT2

    Glucose transporter in beta cells that facilitates glucose entry to stimulate insulin secretion.

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    GLUT4

    Glucose transporter activated by insulin; primarily facilitates glucose entry into muscle cells during exercise.

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    Diabetic Neuropathy

    Nerve damage in diabetes that affects sensory and motor function, often causing pain and numbness.

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    Diabetic Retinopathy

    Eye disease related to diabetes, causing damage to the retina and potentially leading to blindness.

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    Reactive Oxygen Species (ROS)

    Chemically reactive molecules containing oxygen that can damage cells and tissues, increased in diabetes complications.

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    Advanced Glycation End Products (AGEs)

    Compounds formed when sugar binds to proteins; contribute to complications in diabetes.

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    Diabetic Ketoacidosis (DKA)

    Acute complication of diabetes characterized by severe insulin deficiency, causing metabolic acidosis from ketone production.

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    Total Cholesterol Levels

    Desirable levels are less than 200 mg/dL; high levels start at 240 mg/dL.

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    LDL Cholesterol Levels

    Optimal is less than 100 mg/dL; high begins at 160 mg/dL.

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    Fasting Triglycerides Levels

    Normal is under 150 mg/dL; high starts from 200 mg/dL.

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    Non-HDL Cholesterol Levels

    Desirable is less than 130 mg/dL; very high is above 190 mg/dL.

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    HDL Cholesterol Levels

    Low for men is under 40 mg/dL, under 50 mg/dL for women; high is over 60 mg/dL for both.

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    Thyroid-Stimulating Hormone (TSH)

    Normal range is 0.3 to 5 mIU/L; high TSH indicates hypothyroidism.

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    Thyroxine (T4) Levels

    Total T4 normal is 4 to 12 mcg/dL; higher in pregnancy and lower in malnutrition.

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    Triiodothyronine (T3) Levels

    Normal range is 80 to 200 ng/dL; T3 is more potent than T4.

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    Normal Cortisol Levels

    Morning levels are 6 to 25 mcg/dL; evening 3 to 16 mcg/dL.

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    Dexamethasone Suppression Test

    Used to screen for Cushing syndrome; involves administering dexamethasone.

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    Catecholamines

    Hormones released during stress that raise glucose levels.

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    Ketogenesis

    The conversion of fatty acids into ketone bodies.

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    Hypoglycemia Symptoms

    Symptoms occurring at low blood glucose levels, often below 70 mg/dL.

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    Hemoglobin A1c (HbA1c)

    A measure of average blood glucose levels over three months.

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    Fasting Glucose

    Blood glucose measured after not eating for at least 8 hours.

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    Frequent Urination (Polyuria)

    Excessive urination often associated with hyperglycemia.

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    Acetoacetate

    One of the major ketone bodies produced during ketosis.

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    Ketoacidosis Symptoms

    Symptoms of acidosis caused by high ketone levels including fruity breath.

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    Insulin Resistance

    A condition where the body's cells do not respond effectively to insulin.

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    Beta Cell Function

    Insulin-producing cells in the pancreas that respond to blood glucose levels.

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    GLUT-2 Transporter

    A glucose transporter on beta cells; reduced in Type II Diabetes.

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    First Phase Insulin Secretion

    Rapid release of insulin after glucose intake, reduced in Type II Diabetes.

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    Second Phase Insulin Secretion

    Sustained release of insulin after the first phase, present but diminished in Type II Diabetes.

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    Obesity's Role in Diabetes

    Excess body weight increases the risk and complications of Type II Diabetes.

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    Gestational Diabetes

    Diabetes occurring during pregnancy due to insulin resistance.

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    Macrosomia

    Large birth weight in babies, associated with gestational diabetes.

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    C-peptide Levels

    Indicator of insulin production; measurable in Type II diabetes.

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    Complications of Uncontrolled Diabetes

    Health issues arising from lack of management in diabetes, including increased glucose levels.

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    Hyperinsulinemia

    Having higher than normal insulin levels, often seen in Type II Diabetes.

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    Elevated Free Fatty Acids

    Increased levels are a sign of fat breakdown and insulin resistance.

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    Study Notes

    Glucose and Lipid Metabolism (Part 1)

    • Hormones regulating metabolism: Insulin, glucagon, somatostatin, epinephrine, growth hormone, cortisol, gut hormones (GI), and nutrients all play crucial roles.
    • Insulin's role: Promotes glucose, lipid, and protein storage. Acts anabolically. Insulin stimulates glycogenesis, lipogenesis, and protein synthesis, decreasing glucose, amino acids, and fatty acids
    • Glucagon's role: Promotes glucose production, acting catabolically. Triggers glycogenolysis and gluconeogenesis. Also stimulates lipolysis.
    • Somatostatin: Regulates insulin and glucagon (inhibits them).
    • Epinephrine: Increases glucose production and lipolysis.
    • Growth Hormone's role (GH): Increases glucose and protein production (anabolic, primarily protein), and regulates other functions such as sodium retention and lipolysis.
    • Cortisol's role: Increases glucose production, also increases breakdown of protein and fat. Catabolic effects.
    • Gut hormones (GI): Alters insulin secretion and enhance glucose metabolism.
    • Insulin release: Stimulated by increased plasma glucose and amino acid levels.
    • Insulin mechanism of action: Activates PI3 kinase, which is needed to insert GLUT4 transporters into cell membranes, allowing glucose entry. Also involved in protein synthesis and glycogen storage.
    • Fast action of insulin: Facilitates GLUT4 insertion and potassium uptake into cells
    • Intermediate action of insulin: Stimulates protein synthesis and glycolytic enzymes. Promotes glycogen synthesis
    • Slow action of insulin: Inhibits phosphorylase and gluconeogenic enzymes, increases mRNA for lipogenic enzymes.
    • Insulin actions on different tissues: Insulin impacts various organs like liver, fat tissue, and skeletal muscle, driving anabolic reactions.
      • Liver: Stimulates glucose uptake, glycolysis, glycogen synthesis, lipid synthesis, and protein synthesis.
      • Fat tissue: Enhances triglyceride synthesis for storage.
      • Skeletal muscle: Stimulates protein synthesis, boosts glucose and glycogen uptake, and decreases protein breakdown. Also promotes ketone and potassium uptake.
    • Amylin: Secreted by beta cells, inhibits glucagon, and decreases glucose.

    Glucose and Lipid Metabolism (Part 2)

    • Growth Hormone (GH) details: Enhances protein synthesis, reduces insulin sensitivity and promotes lipolysis. A key anabolic hormone in protein synthesis, it is distinct from insulin's broader anabolic effects on glycogen and triglycerides.
    • Insulin-like growth factor 1 (IGF-1): Promotes protein synthesis, anti-lipolytic (prevents fat breakdown) and related effects. Part of GH interaction.
    • Growth hormone actions: Direct and indirect (through IGF-1) promotion of protein synthesis. Effects on bone growth and bone mass.
    • Glucagon secretion: Stimulated by low blood glucose, protein meals, GI hormones, stress, exercise, infection, and fasting.
    • Glucagon actions: Promotes glycogenolysis in the liver and gluconeogenesis. Stimulates lipolysis in fat tissue. Inhibits glucose metabolism.
    • Epinephrine actions: Increased glycogenolysis and gluconeogenesis (in both liver and muscle) and increased blood glucose levels, and lipolysis.
    • Cortisol actions: Stimulates gluconeogenesis, protein breakdown and lipolysis.

    Glucose and Lipid Metabolism (Part 3)

    • Hormonal changes in different metabolic states: Clear patterns of hormonal response to fed, fasting, and other states exist.
    • Combined catabolic effect (glucagon, epinephrine, cortisol) during fasting: Glucagon and epinephrine have a rapid effect, while the effects of cortisol are slower and have synergistic interaction with the previous two.
    • Diabetic states: Detailed overview of Type 1 Diabetes, Type 2 Diabetes and gestational diabetes, including risks, complications, differences in symptoms and progression.
    • Glucose transporters: SGLT1 and SGLT2 (kidneys) and GLUT2 and GLUT4 (various tissues) detailed, emphasizing their roles in glucose uptake, reabsorption.
    • Types of Diabetes: Important overview of Type I and Type 2 Diabetes: differences in symptoms, progression, and insulin dependence.
    • Hormones that increase glucose levels: Glucagon along with epinephrine, thyroid hormones, cortisol and growth hormone. Effects on cellular functions and pathways highlighted.

    Diabetes Diagnosis and Management

    • Diabetes diagnosis criteria: Methods used to diagnose diabetes, including fasting plasma glucose, 2-hour postprandial glucose, random plasma glucose, and HbA1c (glycated hemoglobin) levels.
    • Oral Glucose Tolerance Test (OGTT): Details of the test to assess glucose tolerance over time.
    • Diabetes classification: Categorization of diabetes into Type 1, Type 2, Gestational, and other types.
    • Type 1 Diabetes: Autoimmune disorder, abrupt/rapid onset, generally lean body type and early onset.
    • Type 2 Diabetes: Insulin resistance, gradual onset, typically adult onset and associated with obesity, or poor diet.
    • Gestational Diabetes: Glucose intolerance during pregnancy, increasing incidence related to societal obesity trends.
    • Symptoms and outcomes: Description of various stages and symptoms of hypoglycemia and hyperglycemia, and detailed description of diabetes complications like long-term health implications.

    Markers of Endocrine Function

    • Glucose levels: Normal ranges and importance in diagnosing and monitoring health.
    • Hemoglobin A1c (HbA1c): Reflects average blood glucose over months.
    • Lipid panel: Detailed information on total cholesterol, LDL, HDL, triglycerides, and significance in cardiovascular health.
    • Thyroid markers: Thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) levels, roles in metabolism, and associated pathologies.
    • Adrenal gland markers: Cortisol, ACTH, and related tests (e.g., Dexamethasone suppression test) for diagnosing and managing adrenal disorders.

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    Test your knowledge on metabolic processes and the hormones that regulate them. This quiz covers topics such as glucose formation, hormonal actions, and the roles of specific hormones like insulin and Growth Hormone. Assess your understanding of how these factors influence metabolism.

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