Metabolism and Hormones Quiz

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What is the process of forming new glucose from non-carbohydrate substrates called?

  • Glycogenolysis
  • Glycogenesis
  • Glycolysis
  • Gluconeogenesis (correct)

Which hormone is responsible for stimulating the breakdown of glycogen?

  • Glucagon (correct)
  • Epinephrine
  • Insulin
  • Somatostatin

What is the process of converting acetyl-CoA to fatty acids called?

  • Glycolysis
  • Adipogenesis
  • Lipolysis
  • Lipogenesis (correct)

What is the primary role of insulin in metabolic processes?

<p>Promoting the uptake of glucose by cells (D)</p> Signup and view all the answers

The breakdown of glucose into pyruvate or lactate is known as what process?

<p>Glycolysis (A)</p> Signup and view all the answers

Which of these statements about HSL is correct?

<p>HSL breaks down triglycerides into free fatty acids and glycerol. (B)</p> Signup and view all the answers

Which of the following is NOT an effect of insulin on skeletal muscle?

<p>Increases gluconeogenesis. (A)</p> Signup and view all the answers

What is the primary role of insulin in the liver?

<p>Promote protein and lipid synthesis. (C)</p> Signup and view all the answers

Which of the following events directly triggers insulin release from beta cells?

<p>Calcium influx into the beta cell. (A)</p> Signup and view all the answers

Which of the following inhibits insulin secretion?

<p>Somatostatin. (D)</p> Signup and view all the answers

What is the role of GIP (Gastric Inhibitory Peptide) in regulating insulin secretion?

<p>GIP stimulates insulin secretion in the presence of glucose. (C)</p> Signup and view all the answers

Which of these is NOT a direct action of Growth Hormone (GH)?

<p>Increases glycogen synthesis. (B)</p> Signup and view all the answers

Which of the following is an effect of low Growth Hormone levels?

<p>Smaller protein mass. (D)</p> Signup and view all the answers

What is the main characteristic that differentiates catabolic hormones from anabolic hormones?

<p>Catabolic hormones promote the breakdown of molecules. (D)</p> Signup and view all the answers

Which hormone is primarily involved in regulating blood glucose levels during fasting?

<p>Glucagon. (B)</p> Signup and view all the answers

Which of the following is not a factor that stimulates glucagon secretion?

<p>Glucose (A)</p> Signup and view all the answers

What is the primary effect of glucagon on liver cells?

<p>Stimulates glycogenolysis and gluconeogenesis (D)</p> Signup and view all the answers

Which hormone is primarily responsible for regulating insulin and glucagon secretion?

<p>Somatostatin (D)</p> Signup and view all the answers

Which of the following hormones is NOT associated with increasing plasma glucose levels?

<p>Insulin (C)</p> Signup and view all the answers

Which of the following hormones is directly involved in increasing glucose production by the liver?

<p>Epinephrine (B)</p> Signup and view all the answers

What is the primary effect of glucagon on adipose tissue?

<p>Stimulates lipolysis (C)</p> Signup and view all the answers

Which pancreatic cell type produces insulin?

<p>Beta cells (B)</p> Signup and view all the answers

Which of the following hormones is not involved in the combined catabolic effects during fasting?

<p>Insulin (B)</p> Signup and view all the answers

What is the precursor molecule for insulin synthesis?

<p>Proinsulin (A)</p> Signup and view all the answers

What is the primary function of C-peptide?

<p>Serving as a marker for insulin levels (C)</p> Signup and view all the answers

Which of the following is a characteristic of cortisol's action on glucose metabolism?

<p>Enhances the effects of glucagon and epinephrine on gluconeogensis (B)</p> Signup and view all the answers

Which of the following is not a common symptom of Cushing's Syndrome, a condition of cortisol excess?

<p>Hypoglycemia (A)</p> Signup and view all the answers

Which of the following is NOT a rapid action of insulin?

<p>Activation of glycolytic enzymes (A)</p> Signup and view all the answers

Which enzyme is activated by insulin to facilitate glucose entry into cells?

<p>PI3 kinase (D)</p> Signup and view all the answers

Which of the following is a characteristic of Addison's Disease, a condition of cortisol deficiency?

<p>Hyperpigmentation of the skin (A)</p> Signup and view all the answers

What is the primary role of beta-2 receptors in the body in response to epinephrine?

<p>Glycogenolysis (A)</p> Signup and view all the answers

Which of the following is NOT a stimulus for insulin release?

<p>Decreased blood glucose levels (A)</p> Signup and view all the answers

What is the primary effect of insulin on liver cells?

<p>Promotion of glucose uptake and storage (D)</p> Signup and view all the answers

Epinephrine and glucagon both stimulate glycogenolysis. How are their actions different?

<p>Glucagon only acts on the liver, while epinephrine acts on both the liver and muscle. (D)</p> Signup and view all the answers

Which hormone is directly responsible for the breakdown of triglycerides in adipose tissue?

<p>Hormone-sensitive lipase (HSL) (B)</p> Signup and view all the answers

Which of the following hormones is primarily responsible for increasing blood glucose levels during fasting?

<p>Glucagon (D)</p> Signup and view all the answers

Which of the following hormones is not produced by the pancreas?

<p>Epinephrine (B)</p> Signup and view all the answers

Which two hormones are primarily responsible for the breakdown of glycogen in the liver?

<p>Glucagon and epinephrine (B)</p> Signup and view all the answers

Which hormone promotes protein synthesis in skeletal muscle?

<p>Insulin (A)</p> Signup and view all the answers

Cortisol's effect on glucose metabolism is primarily to:

<p>Enhance the effects of glucagon and epinephrine on gluconeogenesis (C)</p> Signup and view all the answers

Which of the following is not a consequence of cortisol excess (Cushing's syndrome)?

<p>Increased bone density (A)</p> Signup and view all the answers

Which hormone is secreted from beta cells and helps regulate glucose levels by slowing gastric emptying and increasing satiety?

<p>Amylin (A)</p> Signup and view all the answers

Epinephrine's action on the pancreas is to:

<p>Stimulate glucagon secretion (C)</p> Signup and view all the answers

Which hormone produced by adipose tissue is involved in regulating insulin sensitivity and glucose levels?

<p>All of the above (D)</p> Signup and view all the answers

Which hormone is primarily responsible for regulating metabolic rate and overall metabolism?

<p>Thyroid hormones (T3 and T4) (A)</p> Signup and view all the answers

Which of the following is not a factor that stimulates epinephrine release?

<p>Hyperglycemia (D)</p> Signup and view all the answers

What is the primary effect of glucagon during the fasting state?

<p>Stimulates the breakdown of stored glycogen and gluconeogenesis (D)</p> Signup and view all the answers

What is the primary role of insulin in the fed state?

<p>Promotes the uptake and storage of glucose, protein, and fat (C)</p> Signup and view all the answers

Which hormone is primarily elevated during extended fasting?

<p>Cortisol (B)</p> Signup and view all the answers

What is the primary role of ketones in the body during starvation?

<p>Serve as an alternative fuel source for the brain (A)</p> Signup and view all the answers

Which of the following is NOT a symptom of diabetes?

<p>Increased appetite (B)</p> Signup and view all the answers

What is the primary difference between Type 1 and Type 2 diabetes?

<p>Type 1 is caused by insulin deficiency, while Type 2 is caused by insulin insensitivity (A)</p> Signup and view all the answers

Which of the following is a diagnostic criterion for diabetes based on a fasting plasma glucose level?

<p>Over 126 mg/dL (B)</p> Signup and view all the answers

What is the primary cause of Type 1 diabetes?

<p>Autoimmune destruction of beta cells in the pancreas (A)</p> Signup and view all the answers

What is the primary characteristic of Type II diabetes?

<p>Insulin resistance due to factors like obesity and genetics (A)</p> Signup and view all the answers

Which of the following is a hallmark symptom of diabetic ketoacidosis?

<p>High levels of ketones in the blood and urine (B)</p> Signup and view all the answers

What does an A1C test measure?

<p>Average blood glucose levels over the past 3 months (A)</p> Signup and view all the answers

Which hormone is NOT involved in the metabolic response to fasting?

<p>Thyroid Hormone (A)</p> Signup and view all the answers

What is the function of growth hormone during a fasting state?

<p>Inhibit insulin secretion and promote protein synthesis (A)</p> Signup and view all the answers

Which of these is NOT a common autoantibody found in individuals with Type 1 diabetes?

<p>Antibodies to C-peptide (D)</p> Signup and view all the answers

Which of these is a characteristic of gestational diabetes?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary factor contributing to the development of Type II diabetes in children?

<p>Increasing prevalence of childhood obesity (D)</p> Signup and view all the answers

What is considered a desirable level for total cholesterol?

<p>Less than 200 mg/dL (B)</p> Signup and view all the answers

Which level of LDL cholesterol is classified as high?

<p>190 mg/dL or greater (D)</p> Signup and view all the answers

Which factor is known to decrease HDL cholesterol levels?

<p>Poorly controlled diabetes (D)</p> Signup and view all the answers

What is the normal range for Thyroid-Stimulating Hormone (TSH)?

<p>0.3 to 5 mIU/L (D)</p> Signup and view all the answers

What hormone is primarily secreted by the thyroid gland?

<p>T4 (D)</p> Signup and view all the answers

An increased level of TSH indicates which condition?

<p>Hypothyroidism (C)</p> Signup and view all the answers

What is the expected outcome of a Dexamethasone Suppression Test in a healthy individual?

<p>Suppression of cortisol production (A)</p> Signup and view all the answers

What is the normal morning range for cortisol levels?

<p>6 to 25 mcg/dL (B)</p> Signup and view all the answers

What effect does cosyntropin have during the ACTH Stimulation Test in healthy individuals?

<p>Stimulates cortisol secretion (D)</p> Signup and view all the answers

Which condition is suggested by cortisol levels greater than 5 mcg/dL after a Dexamethasone Suppression Test?

<p>Cushing syndrome (D)</p> Signup and view all the answers

What is a consequence of insulin deficiency in diabetic ketoacidosis?

<p>Increased ketone production (A)</p> Signup and view all the answers

Which statement accurately describes the role of SGLT2 in glucose metabolism?

<p>It helps excrete glucose during hyperglycemia. (C)</p> Signup and view all the answers

Which hormone is responsible for breaking down glycogen in the liver?

<p>Glucagon (C)</p> Signup and view all the answers

What might excessive glucose in the urine indicate?

<p>High blood glucose levels (A)</p> Signup and view all the answers

What is a common symptom of diabetes related to excessive thirst?

<p>Polydipsia (D)</p> Signup and view all the answers

Which complication of diabetes is characterized by eye damage that can lead to blindness?

<p>Diabetic retinopathy (A)</p> Signup and view all the answers

Which of the following is associated with increased LDL levels in diabetic patients?

<p>Accelerated atherosclerosis (D)</p> Signup and view all the answers

What is one effect of cortisol in diabetic conditions?

<p>Increased gluconeogenesis (A)</p> Signup and view all the answers

Which mechanism contributes to increased reactive oxygen species (ROS) in diabetes?

<p>Formation of sugar alcohols (D)</p> Signup and view all the answers

What is the primary reason for polydipsia in diabetes?

<p>Osmotic diuresis (A)</p> Signup and view all the answers

What condition is most likely to cause severe metabolic acidosis in diabetes?

<p>Ketoacidosis (C)</p> Signup and view all the answers

Which of the following is not a symptom commonly associated with diabetes?

<p>Weight gain (D)</p> Signup and view all the answers

What role does GLUT4 play in glucose metabolism?

<p>It facilitates insulin-dependent glucose entry into muscle cells. (D)</p> Signup and view all the answers

Which of the following can lead to decreased peripheral glucose utilization?

<p>Growth hormone (D)</p> Signup and view all the answers

What is the major effect of decreased insulin in relation to glucose metabolism?

<p>Decreased glucose uptake (C)</p> Signup and view all the answers

Which ketone form is primarily produced from fatty acids during ketogenesis?

<p>Beta-hydroxybutyrate (B)</p> Signup and view all the answers

What role does epinephrine play in glucose metabolism under stress?

<p>Accelerates glycogen breakdown (C)</p> Signup and view all the answers

Which of the following is a symptom of hyperglycemia?

<p>Excessive thirst (B)</p> Signup and view all the answers

What blood glucose level is typically considered hypoglycemic?

<p>Below 70 mg/dL (B)</p> Signup and view all the answers

What causes the fruity smell in the breath of patients with diabetic ketoacidosis?

<p>Accumulation of acetone (B)</p> Signup and view all the answers

Which process is stimulated by insulin?

<p>Glycogenesis (C)</p> Signup and view all the answers

What is the normal fasting glucose range considered healthy?

<p>70 to 99 mg/dL (A)</p> Signup and view all the answers

What is the relationship between LDL levels and coronary heart disease risk?

<p>Positive relationship (A)</p> Signup and view all the answers

What can result from overdosing on insulin?

<p>Hypoglycemia (C)</p> Signup and view all the answers

What is the main purpose of measuring Hemoglobin A1c (HbA1c)?

<p>To reflect average blood glucose levels over several months (C)</p> Signup and view all the answers

Which scenario can impair gluconeogenesis, increasing the risk of hypoglycemia?

<p>Alcohol consumption (D)</p> Signup and view all the answers

What happens to glucose levels during osmotic diuresis?

<p>Increase in glucose levels (C)</p> Signup and view all the answers

What are common symptoms of repeated hypoglycemic episodes?

<p>Impairment in recognizing hypoglycemic events (B)</p> Signup and view all the answers

Which of these is a characteristic of Type II diabetes?

<p>Insulin resistance (A)</p> Signup and view all the answers

What is a common complication associated with gestational diabetes for babies?

<p>Hypoglycemia (D)</p> Signup and view all the answers

What is the typical time frame for testing for gestational diabetes?

<p>Third trimester (D)</p> Signup and view all the answers

Which of these is NOT a risk factor for gestational diabetes?

<p>Low body mass index (BMI) (B)</p> Signup and view all the answers

What is the most likely reason for the rise in gestational diabetes?

<p>Increased rates of obesity and overweight (C)</p> Signup and view all the answers

Which of these is a complication for mothers with gestational diabetes?

<p>All of the above (D)</p> Signup and view all the answers

What is the most common method used to diagnose gestational diabetes?

<p>Oral glucose tolerance test (OGTT) (B)</p> Signup and view all the answers

Which of these scenarios would most strongly suggest a patient has Type II diabetes?

<p>An obese patient with a history of high blood pressure and a family history of diabetes. (C)</p> Signup and view all the answers

What effect does untreated diabetes have on the liver?

<p>Increased glucose production and decreased glycogen storage (B)</p> Signup and view all the answers

Why might a patient with Type II diabetes have elevated triglyceride levels?

<p>Increased breakdown of fats in adipose tissue (A)</p> Signup and view all the answers

What is a potential consequence of a lack of insulin regulation on amino acid metabolism?

<p>Increased amino acid conversion to glucose (A)</p> Signup and view all the answers

Which component of blood lipids is considered 'good cholesterol'?

<p>HDL (D)</p> Signup and view all the answers

What is a major factor contributing to insulin resistance in Type II diabetes?

<p>Excess weight and physical inactivity. (B)</p> Signup and view all the answers

What does the presence of albumin in the urine indicate in a patient with Type II diabetes?

<p>Kidney dysfunction (B)</p> Signup and view all the answers

What is the primary function of the GLUT-4 transporter?

<p>Transporting glucose into skeletal muscle cells (C)</p> Signup and view all the answers

Flashcards

Glycogenesis

Process of glycogen formation in the body.

Glycogenolysis

Process of breaking down glycogen into glucose.

Glycolysis

The breakdown of glucose into pyruvate or lactate.

Gluconeogenesis

Generation of glucose from non-carbohydrate sources.

Signup and view all the flashcards

Lipogenesis

Conversion of acetyl-CoA to fatty acids.

Signup and view all the flashcards

Insulin

A hormone from the pancreas that regulates glucose and lipid storage.

Signup and view all the flashcards

Glucagon

A hormone from the pancreas that promotes glucose production.

Signup and view all the flashcards

Amylin

A hormone that inhibits glucagon and slows gastric emptying.

Signup and view all the flashcards

Somatostatin (SST)

A hormone that inhibits insulin and glucagon secretion.

Signup and view all the flashcards

Growth Hormone (GH)

A hormone that stimulates glucose production in the liver.

Signup and view all the flashcards

Epinephrine

A hormone that increases glucose production and mobilizes energy in stress.

Signup and view all the flashcards

Cortisol

A hormone that raises glucose levels during stress.

Signup and view all the flashcards

GLP-1

A gut hormone that alters insulin secretion.

Signup and view all the flashcards

Leptin

A hormone that regulates satiety and energy balance.

Signup and view all the flashcards

T3 and T4

Thyroid hormones that regulate metabolism and metabolic rate.

Signup and view all the flashcards

Anabolic Hormones

Hormones that promote storage forms: insulin and growth hormone.

Signup and view all the flashcards

Catabolic Hormones

Hormones that break down larger molecules: glucagon, epinephrine, cortisol.

Signup and view all the flashcards

Insulin Mechanism

Insulin promotes glucose uptake by activating GLUT4 transporters.

Signup and view all the flashcards

Insulin Release Stimuli

Factors that trigger insulin secretion include glucose and amino acids.

Signup and view all the flashcards

Insulin in Fat Tissue

Stimulates triglyceride synthesis and inhibits fat breakdown.

Signup and view all the flashcards

Lipolysis

Breakdown of triglycerides into free fatty acids.

Signup and view all the flashcards

Glucagon Action on Liver

Stimulates glycogenolysis and gluconeogenesis in the liver.

Signup and view all the flashcards

Factors Stimulating Glucagon Secretion

Amino acids, GI hormones, cortisol, exercise, fasting.

Signup and view all the flashcards

Inhibitors of Glucagon Secretion

Glucose, free fatty acids, ketones, insulin.

Signup and view all the flashcards

Epinephrine Effects on Blood Pressure

Increases heart rate and vasoconstriction via beta-1 and alpha-1 receptors.

Signup and view all the flashcards

Combined Catabolic Effects

Glucagon and epinephrine raise glucose; cortisol enhances and has slower effects.

Signup and view all the flashcards

Cushing's Syndrome

Cortisol excess leading to hyperglycemia and poor wound healing.

Signup and view all the flashcards

HSL Function

HSL breaks down triglycerides into free fatty acids and glycerol.

Signup and view all the flashcards

Insulin in Muscle

Insulin increases amino acid and glucose uptake, promotes protein synthesis, and decreases protein breakdown.

Signup and view all the flashcards

Addison's Disease

Cortisol deficiency causing hypoglycemia and low blood pressure.

Signup and view all the flashcards

Insulin in Liver

Insulin promotes glycolysis, glycogen synthesis, and inhibits gluconeogenesis in the liver.

Signup and view all the flashcards

Protein Breakdown

Cortisol promotes protein breakdown in muscle tissue.

Signup and view all the flashcards

Glucose Insulin Secretion

Glucose stimulates insulin secretion through a series of steps starting from glycolysis in pancreatic beta cells.

Signup and view all the flashcards

Hormone Sensitive Lipase

Enzyme activated by glucagon to promote fat breakdown.

Signup and view all the flashcards

Insulin Secretagogues

Substances that stimulate insulin secretion include glucose, amino acids, and intestinal hormones like GIP and GLP-1.

Signup and view all the flashcards

GIP

GIP is an intestinal hormone that stimulates insulin secretion when fat and glucose are present.

Signup and view all the flashcards

Growth Hormone Effects

Growth hormone promotes sodium retention, lipolysis, and protein synthesis, while decreasing insulin sensitivity.

Signup and view all the flashcards

Stimuli for Growth Hormone

Factors that stimulate GH secretion include hypoglycemia, exercise, and sleep.

Signup and view all the flashcards

Fed State

Post-prandial phase when the body absorbs and stores nutrients.

Signup and view all the flashcards

Effect of Insulin

Insulin promotes storage of glucose, protein, and fat following meals.

Signup and view all the flashcards

Glucagon in Fed State

Increased glucagon secretion helps prevent hypoglycemia during the fed state.

Signup and view all the flashcards

Net Effect of Fasting

Mobilization of stored fuel to provide energy when not eating.

Signup and view all the flashcards

Epinephrine Role in Fasting

Increased epinephrine helps promote energy production during fasting.

Signup and view all the flashcards

Growth Hormone in Fasting

Growth hormone increases during fasting to promote fat usage and limit insulin.

Signup and view all the flashcards

Cortisol in Extended Fasting

Stimulates further energy mobilization and increases during extended fasting.

Signup and view all the flashcards

Starvation Effects

During starvation, glucagon is suppressed, while epinephrine and growth hormone increase.

Signup and view all the flashcards

A1C Test

A test that reflects average blood glucose levels over the past 2-3 months.

Signup and view all the flashcards

Diabetes Diagnosis Criteria

Specific glucose levels used to diagnose diabetes type and status.

Signup and view all the flashcards

Type I Diabetes

An autoimmune condition leading to near-zero insulin production primarily in youth.

Signup and view all the flashcards

Type II Diabetes

Characterized by insulin insensitivity, often related to obesity.

Signup and view all the flashcards

Diabetes Symptoms

Common symptoms include polyuria, polydipsia, and polyphagia.

Signup and view all the flashcards

Oral Glucose Tolerance Test (OGTT)

Measures glucose response after consuming a glucose solution.

Signup and view all the flashcards

Ketoacidosis

A serious complication of diabetes characterized by high ketone levels and blood acidity.

Signup and view all the flashcards

Catabolic Function

Shift in metabolism from building up to breaking down substances, leading to increased energy release.

Signup and view all the flashcards

Ketone Production

The process by which the liver produces ketones during low glucose availability; can lead to ketoacidosis.

Signup and view all the flashcards

SGLT1

Sodium-glucose co-transporter in the small intestine, responsible for glucose absorption into the bloodstream.

Signup and view all the flashcards

SGLT2

Sodium-glucose co-transporter in kidneys that reabsorbs glucose back into the blood.

Signup and view all the flashcards

Diabetic Glucosuria

Condition where glucose is present in urine due to high blood sugar levels exceeding renal reabsorption capacity.

Signup and view all the flashcards

GLUT2

Glucose transporter in beta cells that facilitates glucose entry to stimulate insulin secretion.

Signup and view all the flashcards

GLUT4

Glucose transporter activated by insulin; primarily facilitates glucose entry into muscle cells during exercise.

Signup and view all the flashcards

Diabetic Neuropathy

Nerve damage in diabetes that affects sensory and motor function, often causing pain and numbness.

Signup and view all the flashcards

Diabetic Retinopathy

Eye disease related to diabetes, causing damage to the retina and potentially leading to blindness.

Signup and view all the flashcards

Reactive Oxygen Species (ROS)

Chemically reactive molecules containing oxygen that can damage cells and tissues, increased in diabetes complications.

Signup and view all the flashcards

Advanced Glycation End Products (AGEs)

Compounds formed when sugar binds to proteins; contribute to complications in diabetes.

Signup and view all the flashcards

Diabetic Ketoacidosis (DKA)

Acute complication of diabetes characterized by severe insulin deficiency, causing metabolic acidosis from ketone production.

Signup and view all the flashcards

Total Cholesterol Levels

Desirable levels are less than 200 mg/dL; high levels start at 240 mg/dL.

Signup and view all the flashcards

LDL Cholesterol Levels

Optimal is less than 100 mg/dL; high begins at 160 mg/dL.

Signup and view all the flashcards

Fasting Triglycerides Levels

Normal is under 150 mg/dL; high starts from 200 mg/dL.

Signup and view all the flashcards

Non-HDL Cholesterol Levels

Desirable is less than 130 mg/dL; very high is above 190 mg/dL.

Signup and view all the flashcards

HDL Cholesterol Levels

Low for men is under 40 mg/dL, under 50 mg/dL for women; high is over 60 mg/dL for both.

Signup and view all the flashcards

Thyroid-Stimulating Hormone (TSH)

Normal range is 0.3 to 5 mIU/L; high TSH indicates hypothyroidism.

Signup and view all the flashcards

Thyroxine (T4) Levels

Total T4 normal is 4 to 12 mcg/dL; higher in pregnancy and lower in malnutrition.

Signup and view all the flashcards

Triiodothyronine (T3) Levels

Normal range is 80 to 200 ng/dL; T3 is more potent than T4.

Signup and view all the flashcards

Normal Cortisol Levels

Morning levels are 6 to 25 mcg/dL; evening 3 to 16 mcg/dL.

Signup and view all the flashcards

Dexamethasone Suppression Test

Used to screen for Cushing syndrome; involves administering dexamethasone.

Signup and view all the flashcards

Catecholamines

Hormones released during stress that raise glucose levels.

Signup and view all the flashcards

Ketogenesis

The conversion of fatty acids into ketone bodies.

Signup and view all the flashcards

Hypoglycemia Symptoms

Symptoms occurring at low blood glucose levels, often below 70 mg/dL.

Signup and view all the flashcards

Hemoglobin A1c (HbA1c)

A measure of average blood glucose levels over three months.

Signup and view all the flashcards

Fasting Glucose

Blood glucose measured after not eating for at least 8 hours.

Signup and view all the flashcards

Frequent Urination (Polyuria)

Excessive urination often associated with hyperglycemia.

Signup and view all the flashcards

Acetoacetate

One of the major ketone bodies produced during ketosis.

Signup and view all the flashcards

Ketoacidosis Symptoms

Symptoms of acidosis caused by high ketone levels including fruity breath.

Signup and view all the flashcards

Insulin Resistance

A condition where the body's cells do not respond effectively to insulin.

Signup and view all the flashcards

Beta Cell Function

Insulin-producing cells in the pancreas that respond to blood glucose levels.

Signup and view all the flashcards

GLUT-2 Transporter

A glucose transporter on beta cells; reduced in Type II Diabetes.

Signup and view all the flashcards

First Phase Insulin Secretion

Rapid release of insulin after glucose intake, reduced in Type II Diabetes.

Signup and view all the flashcards

Second Phase Insulin Secretion

Sustained release of insulin after the first phase, present but diminished in Type II Diabetes.

Signup and view all the flashcards

Obesity's Role in Diabetes

Excess body weight increases the risk and complications of Type II Diabetes.

Signup and view all the flashcards

Gestational Diabetes

Diabetes occurring during pregnancy due to insulin resistance.

Signup and view all the flashcards

Macrosomia

Large birth weight in babies, associated with gestational diabetes.

Signup and view all the flashcards

C-peptide Levels

Indicator of insulin production; measurable in Type II diabetes.

Signup and view all the flashcards

Complications of Uncontrolled Diabetes

Health issues arising from lack of management in diabetes, including increased glucose levels.

Signup and view all the flashcards

Hyperinsulinemia

Having higher than normal insulin levels, often seen in Type II Diabetes.

Signup and view all the flashcards

Elevated Free Fatty Acids

Increased levels are a sign of fat breakdown and insulin resistance.

Signup and view all the flashcards

Study Notes

Glucose and Lipid Metabolism (Part 1)

  • Hormones regulating metabolism: Insulin, glucagon, somatostatin, epinephrine, growth hormone, cortisol, gut hormones (GI), and nutrients all play crucial roles.
  • Insulin's role: Promotes glucose, lipid, and protein storage. Acts anabolically. Insulin stimulates glycogenesis, lipogenesis, and protein synthesis, decreasing glucose, amino acids, and fatty acids
  • Glucagon's role: Promotes glucose production, acting catabolically. Triggers glycogenolysis and gluconeogenesis. Also stimulates lipolysis.
  • Somatostatin: Regulates insulin and glucagon (inhibits them).
  • Epinephrine: Increases glucose production and lipolysis.
  • Growth Hormone's role (GH): Increases glucose and protein production (anabolic, primarily protein), and regulates other functions such as sodium retention and lipolysis.
  • Cortisol's role: Increases glucose production, also increases breakdown of protein and fat. Catabolic effects.
  • Gut hormones (GI): Alters insulin secretion and enhance glucose metabolism.
  • Insulin release: Stimulated by increased plasma glucose and amino acid levels.
  • Insulin mechanism of action: Activates PI3 kinase, which is needed to insert GLUT4 transporters into cell membranes, allowing glucose entry. Also involved in protein synthesis and glycogen storage.
  • Fast action of insulin: Facilitates GLUT4 insertion and potassium uptake into cells
  • Intermediate action of insulin: Stimulates protein synthesis and glycolytic enzymes. Promotes glycogen synthesis
  • Slow action of insulin: Inhibits phosphorylase and gluconeogenic enzymes, increases mRNA for lipogenic enzymes.
  • Insulin actions on different tissues: Insulin impacts various organs like liver, fat tissue, and skeletal muscle, driving anabolic reactions.
    • Liver: Stimulates glucose uptake, glycolysis, glycogen synthesis, lipid synthesis, and protein synthesis.
    • Fat tissue: Enhances triglyceride synthesis for storage.
    • Skeletal muscle: Stimulates protein synthesis, boosts glucose and glycogen uptake, and decreases protein breakdown. Also promotes ketone and potassium uptake.
  • Amylin: Secreted by beta cells, inhibits glucagon, and decreases glucose.

Glucose and Lipid Metabolism (Part 2)

  • Growth Hormone (GH) details: Enhances protein synthesis, reduces insulin sensitivity and promotes lipolysis. A key anabolic hormone in protein synthesis, it is distinct from insulin's broader anabolic effects on glycogen and triglycerides.
  • Insulin-like growth factor 1 (IGF-1): Promotes protein synthesis, anti-lipolytic (prevents fat breakdown) and related effects. Part of GH interaction.
  • Growth hormone actions: Direct and indirect (through IGF-1) promotion of protein synthesis. Effects on bone growth and bone mass.
  • Glucagon secretion: Stimulated by low blood glucose, protein meals, GI hormones, stress, exercise, infection, and fasting.
  • Glucagon actions: Promotes glycogenolysis in the liver and gluconeogenesis. Stimulates lipolysis in fat tissue. Inhibits glucose metabolism.
  • Epinephrine actions: Increased glycogenolysis and gluconeogenesis (in both liver and muscle) and increased blood glucose levels, and lipolysis.
  • Cortisol actions: Stimulates gluconeogenesis, protein breakdown and lipolysis.

Glucose and Lipid Metabolism (Part 3)

  • Hormonal changes in different metabolic states: Clear patterns of hormonal response to fed, fasting, and other states exist.
  • Combined catabolic effect (glucagon, epinephrine, cortisol) during fasting: Glucagon and epinephrine have a rapid effect, while the effects of cortisol are slower and have synergistic interaction with the previous two.
  • Diabetic states: Detailed overview of Type 1 Diabetes, Type 2 Diabetes and gestational diabetes, including risks, complications, differences in symptoms and progression.
  • Glucose transporters: SGLT1 and SGLT2 (kidneys) and GLUT2 and GLUT4 (various tissues) detailed, emphasizing their roles in glucose uptake, reabsorption.
  • Types of Diabetes: Important overview of Type I and Type 2 Diabetes: differences in symptoms, progression, and insulin dependence.
  • Hormones that increase glucose levels: Glucagon along with epinephrine, thyroid hormones, cortisol and growth hormone. Effects on cellular functions and pathways highlighted.

Diabetes Diagnosis and Management

  • Diabetes diagnosis criteria: Methods used to diagnose diabetes, including fasting plasma glucose, 2-hour postprandial glucose, random plasma glucose, and HbA1c (glycated hemoglobin) levels.
  • Oral Glucose Tolerance Test (OGTT): Details of the test to assess glucose tolerance over time.
  • Diabetes classification: Categorization of diabetes into Type 1, Type 2, Gestational, and other types.
  • Type 1 Diabetes: Autoimmune disorder, abrupt/rapid onset, generally lean body type and early onset.
  • Type 2 Diabetes: Insulin resistance, gradual onset, typically adult onset and associated with obesity, or poor diet.
  • Gestational Diabetes: Glucose intolerance during pregnancy, increasing incidence related to societal obesity trends.
  • Symptoms and outcomes: Description of various stages and symptoms of hypoglycemia and hyperglycemia, and detailed description of diabetes complications like long-term health implications.

Markers of Endocrine Function

  • Glucose levels: Normal ranges and importance in diagnosing and monitoring health.
  • Hemoglobin A1c (HbA1c): Reflects average blood glucose over months.
  • Lipid panel: Detailed information on total cholesterol, LDL, HDL, triglycerides, and significance in cardiovascular health.
  • Thyroid markers: Thyroid-stimulating hormone (TSH), thyroxine (T4), and triiodothyronine (T3) levels, roles in metabolism, and associated pathologies.
  • Adrenal gland markers: Cortisol, ACTH, and related tests (e.g., Dexamethasone suppression test) for diagnosing and managing adrenal disorders.

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

More Like This

Insulin and Glucose Metabolism
3 questions
Metabolisme Karbohidrat
58 questions

Metabolisme Karbohidrat

QuieterSynecdoche9294 avatar
QuieterSynecdoche9294
Diabetes and Hormones Quiz
47 questions
Use Quizgecko on...
Browser
Browser