Podcast
Questions and Answers
What is the primary location where Ketone Bodies are formed?
What is the primary location where Ketone Bodies are formed?
- Liver Cytoplasm
- Muscle Cells
- Liver Mitochondria (correct)
- Adipose Tissue
What is the role of PKA in the breakdown of triacylglycerols?
What is the role of PKA in the breakdown of triacylglycerols?
- Releases FA from monoacylglycerols
- Inhibits hormone-sensitive lipase
- Phosphorylates hormone-sensitive lipase (correct)
- Hydrolyzes FA from triacylglycerols
What is the primary function of Ketone Bodies?
What is the primary function of Ketone Bodies?
- To inhibit fatty acid oxidation
- To synthesize triacylglycerols
- To convert acetyl-CoA to acetoacetate
- To provide metabolic energy (correct)
What is the result of high rates of fatty acid oxidation in the liver?
What is the result of high rates of fatty acid oxidation in the liver?
What is the enzyme responsible for releasing FA from monoacylglycerols?
What is the enzyme responsible for releasing FA from monoacylglycerols?
What is the term for the three biosynthetically related products formed during Ketogenesis?
What is the term for the three biosynthetically related products formed during Ketogenesis?
Which molecule can acetoacetate enzymatically convert to through the action of β-hydroxybutyrate dehydrogenase?
Which molecule can acetoacetate enzymatically convert to through the action of β-hydroxybutyrate dehydrogenase?
What is the metabolic fate of acetoacetate when reacting with succinyl-CoA in mitochondria?
What is the metabolic fate of acetoacetate when reacting with succinyl-CoA in mitochondria?
What triggers the increased release of ketone bodies from the liver for use as fuel by tissues?
What triggers the increased release of ketone bodies from the liver for use as fuel by tissues?
Which tissues consume primarily ketone bodies to preserve glucose for use by the brain in the early stages of starvation?
Which tissues consume primarily ketone bodies to preserve glucose for use by the brain in the early stages of starvation?
What major substrates can Acetoacetate and β-hydroxybutyrate serve for in the biosynthesis of neonatal cerebral lipids?
What major substrates can Acetoacetate and β-hydroxybutyrate serve for in the biosynthesis of neonatal cerebral lipids?
How are ketone bodies utilized by extrahepatic tissues in the body?
How are ketone bodies utilized by extrahepatic tissues in the body?
What enzyme is responsible for the reversal of the β-hydroxybutyrate dehydrogenase reaction?
What enzyme is responsible for the reversal of the β-hydroxybutyrate dehydrogenase reaction?
What is the main reason for the absence of Ketoacyl-CoA-Transferase in the liver?
What is the main reason for the absence of Ketoacyl-CoA-Transferase in the liver?
What is the primary fate of fats when they enter the liver?
What is the primary fate of fats when they enter the liver?
Which hormone phosphorylates ACC, regulating the level of fat oxidation?
Which hormone phosphorylates ACC, regulating the level of fat oxidation?
What is the fate of Acetyl-CoA in the liver when the demand for ATP is high?
What is the fate of Acetyl-CoA in the liver when the demand for ATP is high?
How is the level of ketogenesis in the liver primarily controlled?
How is the level of ketogenesis in the liver primarily controlled?
What is the fate of the small amount of acetone formed by nonenzymatic de-carboxylation of acetoacetate?
What is the fate of the small amount of acetone formed by nonenzymatic de-carboxylation of acetoacetate?
During fasting or carbohydrate starvation, why is oxaloacetate depleted in the liver?
During fasting or carbohydrate starvation, why is oxaloacetate depleted in the liver?
How is acetyl-CoA prevented from entering the Krebs cycle during fasting or carbohydrate starvation?
How is acetyl-CoA prevented from entering the Krebs cycle during fasting or carbohydrate starvation?
What is the initial product formed in ketogenesis from two acetyl-CoA molecules?
What is the initial product formed in ketogenesis from two acetyl-CoA molecules?
Which enzyme catalyzes the formation of β-hydroxy-βmethylglutaryl-CoA (HMG-CoA) during ketogenesis?
Which enzyme catalyzes the formation of β-hydroxy-βmethylglutaryl-CoA (HMG-CoA) during ketogenesis?
Which enzyme catalyzes the interconversion of the ketone bodies acetoacetate and β -hydroxybutyrate?
Which enzyme catalyzes the interconversion of the ketone bodies acetoacetate and β -hydroxybutyrate?
What is the primary cause of diabetic ketoacidosis?
What is the primary cause of diabetic ketoacidosis?
What is the effect of acidic ketone bodies on hemoglobin?
What is the effect of acidic ketone bodies on hemoglobin?
What is the significance of ketones in urine?
What is the significance of ketones in urine?
What is the primary source of energy during exercise?
What is the primary source of energy during exercise?
What is the characteristic of diabetic ketoacidosis?
What is the characteristic of diabetic ketoacidosis?
What is the primary difference between diabetic ketoacidosis and a healthy state?
What is the primary difference between diabetic ketoacidosis and a healthy state?
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