Podcast
Questions and Answers
What is the second leading cause of death in America, after cardiovascular disease?
What is the second leading cause of death in America, after cardiovascular disease?
- Respiratory diseases
- Cancer (correct)
- Diabetes
- Stroke
What are the two types of chemotherapy mentioned as advances in cancer treatment over the last 100 years?
What are the two types of chemotherapy mentioned as advances in cancer treatment over the last 100 years?
- Cytotoxic chemotherapy and radiation therapy
- Immunotherapy and hormone therapy
- Targeted chemotherapy and immunotherapy
- Cytotoxic chemotherapy and targeted chemotherapy (correct)
How can cancer screening impact society?
How can cancer screening impact society?
- It can lead to overdiagnosis in certain types of cancers (correct)
- It has no significant impact on society
- It can predict pre-cancerous lesions in all types of cancers
- It can prevent the occurrence of pre-cancerous lesions
What is the main function of the RB checkpoint in the normal cell cycle progression?
What is the main function of the RB checkpoint in the normal cell cycle progression?
What happens if the Rb gene does not work properly in the cell cycle progression?
What happens if the Rb gene does not work properly in the cell cycle progression?
What impact do errors in DNA replication have on the activation of the P53 protein?
What impact do errors in DNA replication have on the activation of the P53 protein?
What is a key characteristic that differentiates malignant cells from non-malignant cells?
What is a key characteristic that differentiates malignant cells from non-malignant cells?
What is the function of telomerase in cancer cells?
What is the function of telomerase in cancer cells?
Which protein is upregulated in many cancer cells and causes the growth of new blood vessels?
Which protein is upregulated in many cancer cells and causes the growth of new blood vessels?
What is a common feature of tumor genetic changes in cancer cells?
What is a common feature of tumor genetic changes in cancer cells?
Which gene mutation is found at the interphase between G1 and S phases and increases the chance of mutation during cell proliferation?
Which gene mutation is found at the interphase between G1 and S phases and increases the chance of mutation during cell proliferation?
What serves as a protective function against potentially dangerous cellular abnormalities?
What serves as a protective function against potentially dangerous cellular abnormalities?
Which characteristic of cancer cells is associated with the inability to repair DNA?
Which characteristic of cancer cells is associated with the inability to repair DNA?
Which gene encodes for proteins that make cells grow and divide, and when mutated, can lead to increased cellular activity?
Which gene encodes for proteins that make cells grow and divide, and when mutated, can lead to increased cellular activity?
What is the primary mechanism of action of alkylating agents in disrupting DNA synthesis and replication?
What is the primary mechanism of action of alkylating agents in disrupting DNA synthesis and replication?
Which toxic effect is unique to cyclophosphamide and ifosfamide among alkylating agents?
Which toxic effect is unique to cyclophosphamide and ifosfamide among alkylating agents?
What type of gene is TP53 in the context of cancer development?
What type of gene is TP53 in the context of cancer development?
Which hallmark characteristic of cancer may develop without mutational changes?
Which hallmark characteristic of cancer may develop without mutational changes?
What is the main metabolite responsible for the development of cyclo-/ifosfamide-induced hemorrhagic cystitis?
What is the main metabolite responsible for the development of cyclo-/ifosfamide-induced hemorrhagic cystitis?
Which drug can be used to mitigate acrolein-induced toxicity by mimicking glutathione?
Which drug can be used to mitigate acrolein-induced toxicity by mimicking glutathione?
What is the main strategy for preventing cisplatin-induced nephrotoxicity?
What is the main strategy for preventing cisplatin-induced nephrotoxicity?
What is the mechanism of action of methotrexate?
What is the mechanism of action of methotrexate?
What is the role of leucovorin as it pertains to high dose methotrexate?
What is the role of leucovorin as it pertains to high dose methotrexate?
What is a unique toxicity associated with platinum (Cisplatin) agents?
What is a unique toxicity associated with platinum (Cisplatin) agents?
What is the primary role of Leucovorin in the presence of high-dose methotrexate (MTX)?
What is the primary role of Leucovorin in the presence of high-dose methotrexate (MTX)?
Which enzyme is primarily responsible for the bio-activation of capecitabine?
Which enzyme is primarily responsible for the bio-activation of capecitabine?
What is the pharmacogenetic determinant of 5-FU/capecitabine toxicity that leads to life-threatening toxicity in individuals with deficiency?
What is the pharmacogenetic determinant of 5-FU/capecitabine toxicity that leads to life-threatening toxicity in individuals with deficiency?
What are the hallmark toxicities of cytarabine and gemcitabine, respectively?
What are the hallmark toxicities of cytarabine and gemcitabine, respectively?
What is the mechanism of action of purine analogs in inhibiting DNA synthesis?
What is the mechanism of action of purine analogs in inhibiting DNA synthesis?
What is the primary reason why purine analogs increase the risk of opportunistic infections?
What is the primary reason why purine analogs increase the risk of opportunistic infections?
Which purine analog requires prophylactic antimicrobials?
Which purine analog requires prophylactic antimicrobials?
Which drug interaction is associated with purine analogs?
Which drug interaction is associated with purine analogs?
Which microtubule inhibitor causes hypersensitivity reactions related to its diluent?
Which microtubule inhibitor causes hypersensitivity reactions related to its diluent?
What unique toxicity is associated with vincristine?
What unique toxicity is associated with vincristine?
What is the unique step required to prepare and administer paclitaxel (Taxol)?
What is the unique step required to prepare and administer paclitaxel (Taxol)?
What is the brand name for docetaxel?
What is the brand name for docetaxel?
What is the conventional maximum dose of vincristine?
What is the conventional maximum dose of vincristine?
What are the unique toxicities of topoisomerase I inhibitors?
What are the unique toxicities of topoisomerase I inhibitors?
How can toxicities from topoisomerase I inhibitors be limited or treated?
How can toxicities from topoisomerase I inhibitors be limited or treated?
What are the pharmacokinetic predictors of effect to topoisomerase I inhibitors?
What are the pharmacokinetic predictors of effect to topoisomerase I inhibitors?
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