31 Questions
What is the basic unit of heredity?
Gene
Which genetic disorder is caused by a single change in a single gene?
Sickle-cell anemia
According to Mendel, what is essential for following genes from one generation to another?
Observable variation
Which statement reflects one of the general assumptions of Mendel's work?
Variation is inherited by genetic laws
Which genetic disorder is an example of a trait caused by complex interactions between many genes?
Height
What encodes a protein or RNA?
Gene
What was the focus of Mendel's experiments with pea plants?
The laws of inheritance
Which of the following theories contributed to misinterpretation of variation in selective breeding experiments during Mendel's time?
The homunculus
What was the key to the success of Mendel's experiments with pea plants?
Discrete traits that remained constant in crosses within a line
Which of the following is a key learning objective related to genetic analysis according to Mendel?
Predicting genotypic and phenotypic ratios among progeny of complex multi-hybrid crosses
What did Mendel's monohybrid crosses reveal?
The units of inheritance and the law of segregation
What did Mendel's paper 'Experiments in plant hybrids' become?
The cornerstone of modern genetics
What were two misleading theories of inheritance at the time of Mendel’s studies?
Homunculus and blended inheritance
What was Mendel’s experimental organism?
(a)
What did Mendel study in peas?
7
Which enzyme is encoded by the Y allele?
Stay green enzyme
What happens when the r allele is present?
Sucrose and unbranched starch build up
According to the molecular explanation, what does the Y allele not make?
Sgr
What is the effect of the r allele not making Sbe1?
Sucrose and unbranched starch buildup
Which genetic disorder exhibits dominant inheritance?
Familial hypercholesterolemia
Which of the following diseases is caused by a recessive allele?
Sickle cell anemia
What pattern of inheritance does Huntington's disease exhibit?
Dominant inheritance
Which genetic disorder is characterized by a high frequency and caused by a recessive allele?
Gaucher disease
In which chromosome is cystic fibrosis located?
7q
What is the recurrence risk for each sibling of a proband with autosomal recessive inheritance?
25%
Which characteristic is typically seen in autosomal recessive inheritance?
More common with consanguinity
What characteristic helps recognize dominant traits in pedigrees?
Phenotype appears in every generation
What is the most common single-gene trait caused by a dominant allele in humans?
Retinoblastoma
Which genetic disorder has a chromosome location at 1/1000 and can be caused by a recessive allele?
Gaucher disease
Which disease is NOT an example of a single-gene trait caused by a dominant allele?
Sickle cell anemia
What pattern of inheritance does cystic fibrosis exhibit?
Recessive inheritance
Test your knowledge of Chapter 01 'Mendel’s Principles of Heredity' from the book 'Genetics: From Genes to Genomes' by Goldberg and Fischer. The quiz covers topics such as inheritance, genetic analysis according to Mendel, and Mendelian inheritance in humans.
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