Mendelian Inheritance Quiz
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Questions and Answers

In a two-factor cross, what is the phenotypic ratio observed in the F2 generation for the traits round/wrinkled and yellow/green seeds?

  • 9:3:3:1 (correct)
  • 3:1
  • 1:2:1
  • 1:1
  • Genetic recombination can only occur due to independent assortment.

    False (B)

    What is the name of the method used to analyze crosses involving three or more genes that involves multiplying individual probabilities?

    Multiplication method

    The ______ is a diagram used to predict the possible genotypes and phenotypes of offspring in a cross.

    <p>Punnett square</p> Signup and view all the answers

    Match the following terms with their definitions:

    <p>Independent assortment = The separation of alleles for different traits into gametes independently of each other. Genetic recombination = The process of offspring inheriting a combination of alleles that differs from the parental generation. Two-factor cross = A cross involving two traits F2 generation = The generation resulting from a cross between two F1 individuals.</p> Signup and view all the answers

    What is the significance level commonly used in hypothesis testing that corresponds to a P value of 0.05?

    <p>0.05 (C)</p> Signup and view all the answers

    The Chi Square Test uses a formula that involves the difference between observed and expected data.

    <p>True (A)</p> Signup and view all the answers

    What does the symbol ∑ represent in the Chi Square Test formula?

    <p>Sum of calculations for each category</p> Signup and view all the answers

    In the Chi Square Test, a P value of less than _______ indicates that the null hypothesis can be rejected.

    <p>0.05</p> Signup and view all the answers

    Match the following degrees of freedom with their corresponding critical value at P = 0.05:

    <p>1 = 3.841 2 = 5.991 3 = 7.815 4 = 9.488</p> Signup and view all the answers

    What is the main purpose of the Chi Square Test?

    <p>To test if the observed frequencies match expected frequencies (C)</p> Signup and view all the answers

    What is the result of a P cross between tall and dwarf stem plants?

    <p>All tall plants (B)</p> Signup and view all the answers

    A higher Chi Square value always leads to the acceptance of the null hypothesis.

    <p>False (B)</p> Signup and view all the answers

    The F2 generation can always produce plants that show both dominant and recessive traits.

    <p>True (A)</p> Signup and view all the answers

    What does Mendel's law of segregation state?

    <p>The two copies of a gene separate from each other during gamete formation.</p> Signup and view all the answers

    The formula for the Chi Square Test is x = ________ (O - E)² / E.

    <p>Σ</p> Signup and view all the answers

    In a P cross between purple and white flowers, all flowers in the F1 generation were __________.

    <p>purple</p> Signup and view all the answers

    What is the typical ratio of tall to dwarf plants observed in the F2 generation?

    <p>2.84:1 (A)</p> Signup and view all the answers

    The particulate theory of inheritance states that traits blend together in offspring.

    <p>False (B)</p> Signup and view all the answers

    Which generation results from the self-fertilization of F1 generation plants?

    <p>F2 generation</p> Signup and view all the answers

    What are gain-of-function alleles?

    <p>Alleles that enhance the function of a gene (A)</p> Signup and view all the answers

    Loss-of-function alleles are typically inherited in a dominant manner.

    <p>False (B)</p> Signup and view all the answers

    Who established the chromosome theory of inheritance?

    <p>Mendel</p> Signup and view all the answers

    Chromosomes are replicated and passed from parent to __________.

    <p>offspring</p> Signup and view all the answers

    Match the following principles of the Chromosome Theory of Inheritance to their descriptions:

    <p>1 = Chromosomes contain the genetic material 2 = Chromosomes are replicated and passed from parent to offspring 3 = Most eukaryotic cells contain chromosomes in homologous pairs 4 = During meiosis, segregations of homologs occur</p> Signup and view all the answers

    During which phase of meiosis do homologous chromosomes segregate?

    <p>Meiosis I (D)</p> Signup and view all the answers

    What does the law of independent assortment state?

    <p>Different types of nonhomologous chromosomes segregate independently during gamete formation.</p> Signup and view all the answers

    Each parent contributes two sets of chromosomes to its offspring.

    <p>False (B)</p> Signup and view all the answers

    What is the probability that two out of five children will have blue eyes if both parents are heterozygous brown-eyed?

    <p>0.16 (C)</p> Signup and view all the answers

    The ratio from a Punnett square of a Bb x Bb cross is 1 BB : 2 Bb : 1 bb.

    <p>False (B)</p> Signup and view all the answers

    What does the symbol '!' denote in the binomial expansion equation?

    <p>factorial</p> Signup and view all the answers

    The probability of a blue-eyed child from a Bb x Bb cross is ____.

    <p>1/4</p> Signup and view all the answers

    When using the binomial expansion equation for Bb x Bb, what is the value of p?

    <p>1/4 (B)</p> Signup and view all the answers

    The factorial of zero is equal to one.

    <p>True (A)</p> Signup and view all the answers

    How many total events are considered if two heterozygous individuals have five children?

    <p>5</p> Signup and view all the answers

    What is the purpose of pedigree analysis?

    <p>To determine the pattern of inheritance of traits in humans (D)</p> Signup and view all the answers

    Cystic fibrosis is an example of a disease that follows a dominant pattern of inheritance.

    <p>False (B)</p> Signup and view all the answers

    What does the term 'allele' refer to in genetics?

    <p>An allele is a variant form of a gene.</p> Signup and view all the answers

    In a recessive pattern of inheritance, two unaffected heterozygous individuals can have ______ of their offspring affected.

    <p>25%</p> Signup and view all the answers

    What percentage of offspring will be affected if two affected individuals have children in a recessive inheritance pattern?

    <p>100% (D)</p> Signup and view all the answers

    An affected individual in a dominant inheritance pattern must have at least one affected parent.

    <p>True (A)</p> Signup and view all the answers

    What is the role of the CFTR protein in the human body?

    <p>The CFTR protein regulates ion transport across the cell membrane.</p> Signup and view all the answers

    The mutant allele of the CFTR gene causes abnormalities in the ______, intestine, sweat glands, and lungs.

    <p>pancreas</p> Signup and view all the answers

    In pedigree analysis, what does it mean if an individual is represented by a shaded circle?

    <p>It indicates that the individual is affected by the trait being studied.</p> Signup and view all the answers

    Flashcards

    Two Factor Cross

    A genetic cross examining two traits simultaneously, observing offspring distributions.

    Independent Assortment

    Mendel's principle stating genes segregate independently during gamete formation.

    Genetic Recombination

    The generation of offspring with combinations of alleles different from their parents.

    Punnett Square

    A diagram used to predict the genotype probabilities of offspring from a genetic cross.

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    Three-Factor Cross

    A genetic cross involving three traits, computed using more complex methods due to size.

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    P Cross

    A cross between two parental plants differing in one character.

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    F1 Generation

    The first generation of offspring resulting from a P cross.

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    F2 Generation

    The generation produced by self-fertilizing F1 plants.

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    Dominant Trait

    A trait that is expressed over the recessive trait in F1.

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    Recessive Trait

    A trait that is masked by the dominant trait in F1.

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    Particulate Theory

    The idea that traits are inherited as discrete units called genes.

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    Law of Segregation

    The principle that gene copies separate during gamete formation.

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    Phenotypic Ratio

    The observed ratio of traits in the offspring, like 3:1.

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    Loss-of-function alleles

    Defective gene copies that impair function, often inherited recessively.

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    Mendel's studies

    Mendel unknowingly used seven loss-of-function alleles in his pea plant experiments.

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    Chromosome Theory of Inheritance

    Chromosomes transmit genetic determinants of traits, explaining Mendelian inheritance patterns.

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    Genetic material in chromosomes

    Chromosomes contain the genetic information necessary for inheritance.

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    Diploid cells

    Eukaryotic cells with homologous chromosomes in pairs, each parent contributes one set.

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    Homologous segregation in meiosis

    Homologous chromosomes separate during meiosis I, leading to allele segregation.

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    Law of Independent Assortment

    Different types of chromosomes segregate independently during gamete formation in meiosis.

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    P Value

    A measure that indicates the probability of obtaining test results at least as extreme as the observed results, assuming the null hypothesis is true.

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    Chi Square Test

    A statistical test used to determine if there is a significant association between categorical variables.

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    Observed Data (O)

    The actual data collected from an experiment or study in each category.

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    Expected Data (E)

    The theoretical distribution of data in each category based on the hypothesis.

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    Degrees of Freedom

    The number of independent values or quantities that can vary in the analysis, can affect the results of the test.

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    Chi Square Formula

    The formula used in the Chi Square test: x² = ∑(O−E)²/E where O = observed and E = expected data.

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    Null Hypothesis

    A statement suggesting no effect or no difference, which is tested against the collected data.

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    Significance Level

    A cutoff point (often 0.05) at which you reject the null hypothesis due to low probability of random occurrence.

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    Pedigree Analysis

    A method used to determine inheritance patterns of traits in humans.

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    Inheritance Patterns

    The ways in which traits or diseases are passed from parents to offspring.

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    Genetic Alleles

    Variants of a gene that can cause disease or normal function.

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    Mendelian Inheritance

    Inheritance patterns that follow Mendel's laws, can be dominant or recessive.

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    Recessive Inheritance

    A pattern where two unaffected heterozygous parents have a 25% chance of an affected offspring.

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    Dominant Inheritance

    A pattern where an affected individual has inherited the gene from at least one affected parent.

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    Cystic Fibrosis

    A genetic disorder caused by a mutation affecting ion transport, following an autosomal recessive pattern.

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    CFTR Protein

    The protein encoded by the cystic fibrosis gene that regulates ion transport across membranes.

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    Affected Offspring

    Children who inherit a genetic disorder from parents, based on the inheritance pattern.

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    New Mutation

    A spontaneous genetic change occurring during gamete formation that can lead to a dominant trait.

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    Product Rule

    Method to calculate the probability of independent events occurring together.

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    Congenital Analgesia Probability

    The chance of offspring having congenital analgesia from Pp x Pp is 1.6%.

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    Binomial Expansion Equation

    A formula to calculate probabilities of unordered events.

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    Factorial (!)

    The product of all positive integers up to a given number n.

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    Probability Notation

    P = probability of outcome; n = total events; x = events in one category.

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    Heterozygous Cross

    Mating between two individuals with different alleles (Bb x Bb).

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    Blue Eyed Probability

    The probability of having 2 blue-eyed children from 5 total.

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    Study Notes

    Mendelian Inheritance

    • Mendel, the "father of genetics", performed thousands of pea plant crosses from 1856-1864 to study inheritance patterns.
    • He used the garden pea (Pisum sativum)
    • His work, "Experiments on Plant Hybrids", was published in 1866 but ignored for 34 years.
    • In 1900, Mendel's work was rediscovered.
    • Mendel carried out self-fertilization and cross-fertilization experiments.
    • Self-fertilization: Pollination and egg come from the same plant.
    • Cross-fertilization: Pollination and egg come from different plants (a controlled breeding experiment)

    Mendel's Study of Pea Plants

    • Traits, or variants, are observable characteristics.
    • A true-breeder produces the same trait over generations.
    • Examples of pea plant traits include height, flower color, seed shape, and seed color.

    Types of crosses

    • Single factor crosses: involve two plants that differ in only one trait.
    • The parental generation (P) is crossed to produce the first-generation (F1) offspring.
    • The F1 plants self-fertilize to produce the second-generation (F2) offspring seeds.

    Data from Single Factor Crosses

    • Data on the results of various single factor crosses.

    Interpreting the data

    • Traits do not blend; one variant is dominant, the other recessive; this is observed in the F1 generation.
    • Particulate theory of inheritance: traits are inherited as discrete units called "genes" that remain unchanged.

    Law of Segregation

    • Two copies of a gene separate during gamete formation.
    • Each gamete carries one copy of each gene.
    • "Alleles"—different forms of a gene.
    • "Homozygous" = two identical alleles
    • "Heterozygous" = two different alleles.
    • "Genotype" = genetic makeup.
    • "Phenotype" = observable traits.

    Punnett Squares

    • Used to predict the outcome of simple genetic crosses.
    • Proposed by Reginald Punnett.
    • Example of a cross between heterozygous tall plants (Tt x Tt).

    Two Factor Crosses

    • Involve crossing plants that differ in two traits.
    • Example of traits: seed texture (round vs. wrinkled) and seed color (yellow vs. green)
    • Two possible inheritance patterns:
    • Linked assortment (genes close together on the same chromosome remain together during gamete formation),
    • Independent assortment (genes are on separate chromosomes and segregate independently during gamete formation).

    Data from Two-Factor Crosses

    • Data from results of various two factor crosses, which showed patterns that were closer to expectations of independent assortment than linked assortment.

    Law of Independent Assortment

    • Different traits are independently inherited during gamete formation.
    • Two factors assort independently during gamete formation.

    Mendel's Law of Independent Assortment

    • Genes are linked if they are on the same chromosome.
    • Genetic recombination happens when the offspring receives a combination of alleles that differs from the parent generation due to:
    • Independent assortment,
    • Crossing over. Note crossing over is not in chapter 3.

    Probability

    • The probability an event will occur is the chance of it happening again in the future.
    • Probability calculations are used to predicts results.
    • Probability = Number of favorable outcomes/Total number of possible outcomes

    Chi Square Test

    • A statistical method to determine if there is a good fit between the data and hypothesis.

    P Value

    • The P-value is an important tool in statistics that measures the probability of observing results as extreme as, or more extreme than, the observed results, assuming the null hypothesis is true. A lower P-value suggests stronger evidence against the null hypothesis (supporting your desired outcome).

    Modern Genetics

    • Defective copies of genes are called 'loss-of-function alleles'.
    • Loss-of-function alleles are commonly inherited recessively (the gene must be present on both allele copies.)

    The Chromosome Theory of Inheritance

    • Chromosomes carry the genetic material.
    • Chromosomes are replicated and transmitted to offspring.
    • Eukaryotic cell nuclei contain chromosomes in homologous pairs.
    • During meiosis, homologs and different chromosome types segregate independently.
    • Each parent provides one chromosome set to the offspring.

    Pedigree Analysis

    • Used to determine patterns of inheritance of traits in humans.
    • Pedigrees demonstrate a family's inheritance of a genetic trait over generations.
    • This can determine if a trait or disease is dominant or recessive.
    • Genes that are related to diseases can exist as non-disease-causing alleles or as disease-causing mutant alleles.

    Additional Information

    • Concepts of product rule and binominal expansion are useful for probability calculations in genetics problems, especially when the genetic trait is expressed over multiple factors (multiple genes).
    • Calculating the probability of a specific outcome (e.g. congenital analgesia in offspring).

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    Description

    Test your knowledge on Mendel's experiments and his fundamental contributions to genetics. This quiz covers Mendel's pea plant studies, types of crosses, and the characteristics of traits. Challenge yourself with questions about key concepts in inheritance patterns and genetic traits.

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