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Questions and Answers
In a two-factor cross, what is the phenotypic ratio observed in the F2 generation for the traits round/wrinkled and yellow/green seeds?
In a two-factor cross, what is the phenotypic ratio observed in the F2 generation for the traits round/wrinkled and yellow/green seeds?
Genetic recombination can only occur due to independent assortment.
Genetic recombination can only occur due to independent assortment.
False (B)
What is the name of the method used to analyze crosses involving three or more genes that involves multiplying individual probabilities?
What is the name of the method used to analyze crosses involving three or more genes that involves multiplying individual probabilities?
Multiplication method
The ______ is a diagram used to predict the possible genotypes and phenotypes of offspring in a cross.
The ______ is a diagram used to predict the possible genotypes and phenotypes of offspring in a cross.
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Match the following terms with their definitions:
Match the following terms with their definitions:
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What is the significance level commonly used in hypothesis testing that corresponds to a P value of 0.05?
What is the significance level commonly used in hypothesis testing that corresponds to a P value of 0.05?
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The Chi Square Test uses a formula that involves the difference between observed and expected data.
The Chi Square Test uses a formula that involves the difference between observed and expected data.
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What does the symbol ∑ represent in the Chi Square Test formula?
What does the symbol ∑ represent in the Chi Square Test formula?
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In the Chi Square Test, a P value of less than _______ indicates that the null hypothesis can be rejected.
In the Chi Square Test, a P value of less than _______ indicates that the null hypothesis can be rejected.
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Match the following degrees of freedom with their corresponding critical value at P = 0.05:
Match the following degrees of freedom with their corresponding critical value at P = 0.05:
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What is the main purpose of the Chi Square Test?
What is the main purpose of the Chi Square Test?
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What is the result of a P cross between tall and dwarf stem plants?
What is the result of a P cross between tall and dwarf stem plants?
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A higher Chi Square value always leads to the acceptance of the null hypothesis.
A higher Chi Square value always leads to the acceptance of the null hypothesis.
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The F2 generation can always produce plants that show both dominant and recessive traits.
The F2 generation can always produce plants that show both dominant and recessive traits.
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What does Mendel's law of segregation state?
What does Mendel's law of segregation state?
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The formula for the Chi Square Test is x = ________ (O - E)² / E.
The formula for the Chi Square Test is x = ________ (O - E)² / E.
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In a P cross between purple and white flowers, all flowers in the F1 generation were __________.
In a P cross between purple and white flowers, all flowers in the F1 generation were __________.
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What is the typical ratio of tall to dwarf plants observed in the F2 generation?
What is the typical ratio of tall to dwarf plants observed in the F2 generation?
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The particulate theory of inheritance states that traits blend together in offspring.
The particulate theory of inheritance states that traits blend together in offspring.
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Which generation results from the self-fertilization of F1 generation plants?
Which generation results from the self-fertilization of F1 generation plants?
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What are gain-of-function alleles?
What are gain-of-function alleles?
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Loss-of-function alleles are typically inherited in a dominant manner.
Loss-of-function alleles are typically inherited in a dominant manner.
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Who established the chromosome theory of inheritance?
Who established the chromosome theory of inheritance?
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Chromosomes are replicated and passed from parent to __________.
Chromosomes are replicated and passed from parent to __________.
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Match the following principles of the Chromosome Theory of Inheritance to their descriptions:
Match the following principles of the Chromosome Theory of Inheritance to their descriptions:
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During which phase of meiosis do homologous chromosomes segregate?
During which phase of meiosis do homologous chromosomes segregate?
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What does the law of independent assortment state?
What does the law of independent assortment state?
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Each parent contributes two sets of chromosomes to its offspring.
Each parent contributes two sets of chromosomes to its offspring.
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What is the probability that two out of five children will have blue eyes if both parents are heterozygous brown-eyed?
What is the probability that two out of five children will have blue eyes if both parents are heterozygous brown-eyed?
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The ratio from a Punnett square of a Bb x Bb cross is 1 BB : 2 Bb : 1 bb.
The ratio from a Punnett square of a Bb x Bb cross is 1 BB : 2 Bb : 1 bb.
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What does the symbol '!' denote in the binomial expansion equation?
What does the symbol '!' denote in the binomial expansion equation?
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The probability of a blue-eyed child from a Bb x Bb cross is ____.
The probability of a blue-eyed child from a Bb x Bb cross is ____.
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When using the binomial expansion equation for Bb x Bb, what is the value of p?
When using the binomial expansion equation for Bb x Bb, what is the value of p?
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The factorial of zero is equal to one.
The factorial of zero is equal to one.
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How many total events are considered if two heterozygous individuals have five children?
How many total events are considered if two heterozygous individuals have five children?
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What is the purpose of pedigree analysis?
What is the purpose of pedigree analysis?
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Cystic fibrosis is an example of a disease that follows a dominant pattern of inheritance.
Cystic fibrosis is an example of a disease that follows a dominant pattern of inheritance.
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What does the term 'allele' refer to in genetics?
What does the term 'allele' refer to in genetics?
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In a recessive pattern of inheritance, two unaffected heterozygous individuals can have ______ of their offspring affected.
In a recessive pattern of inheritance, two unaffected heterozygous individuals can have ______ of their offspring affected.
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What percentage of offspring will be affected if two affected individuals have children in a recessive inheritance pattern?
What percentage of offspring will be affected if two affected individuals have children in a recessive inheritance pattern?
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An affected individual in a dominant inheritance pattern must have at least one affected parent.
An affected individual in a dominant inheritance pattern must have at least one affected parent.
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What is the role of the CFTR protein in the human body?
What is the role of the CFTR protein in the human body?
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The mutant allele of the CFTR gene causes abnormalities in the ______, intestine, sweat glands, and lungs.
The mutant allele of the CFTR gene causes abnormalities in the ______, intestine, sweat glands, and lungs.
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In pedigree analysis, what does it mean if an individual is represented by a shaded circle?
In pedigree analysis, what does it mean if an individual is represented by a shaded circle?
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Flashcards
Two Factor Cross
Two Factor Cross
A genetic cross examining two traits simultaneously, observing offspring distributions.
Independent Assortment
Independent Assortment
Mendel's principle stating genes segregate independently during gamete formation.
Genetic Recombination
Genetic Recombination
The generation of offspring with combinations of alleles different from their parents.
Punnett Square
Punnett Square
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Three-Factor Cross
Three-Factor Cross
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P Cross
P Cross
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F1 Generation
F1 Generation
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F2 Generation
F2 Generation
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Dominant Trait
Dominant Trait
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Recessive Trait
Recessive Trait
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Particulate Theory
Particulate Theory
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Law of Segregation
Law of Segregation
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Phenotypic Ratio
Phenotypic Ratio
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Loss-of-function alleles
Loss-of-function alleles
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Mendel's studies
Mendel's studies
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Chromosome Theory of Inheritance
Chromosome Theory of Inheritance
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Genetic material in chromosomes
Genetic material in chromosomes
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Diploid cells
Diploid cells
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Homologous segregation in meiosis
Homologous segregation in meiosis
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Law of Independent Assortment
Law of Independent Assortment
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P Value
P Value
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Chi Square Test
Chi Square Test
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Observed Data (O)
Observed Data (O)
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Expected Data (E)
Expected Data (E)
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Degrees of Freedom
Degrees of Freedom
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Chi Square Formula
Chi Square Formula
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Null Hypothesis
Null Hypothesis
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Significance Level
Significance Level
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Pedigree Analysis
Pedigree Analysis
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Inheritance Patterns
Inheritance Patterns
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Genetic Alleles
Genetic Alleles
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Mendelian Inheritance
Mendelian Inheritance
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Recessive Inheritance
Recessive Inheritance
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Dominant Inheritance
Dominant Inheritance
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Cystic Fibrosis
Cystic Fibrosis
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CFTR Protein
CFTR Protein
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Affected Offspring
Affected Offspring
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New Mutation
New Mutation
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Product Rule
Product Rule
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Congenital Analgesia Probability
Congenital Analgesia Probability
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Binomial Expansion Equation
Binomial Expansion Equation
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Factorial (!)
Factorial (!)
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Probability Notation
Probability Notation
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Heterozygous Cross
Heterozygous Cross
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Blue Eyed Probability
Blue Eyed Probability
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Study Notes
Mendelian Inheritance
- Mendel, the "father of genetics", performed thousands of pea plant crosses from 1856-1864 to study inheritance patterns.
- He used the garden pea (Pisum sativum)
- His work, "Experiments on Plant Hybrids", was published in 1866 but ignored for 34 years.
- In 1900, Mendel's work was rediscovered.
- Mendel carried out self-fertilization and cross-fertilization experiments.
- Self-fertilization: Pollination and egg come from the same plant.
- Cross-fertilization: Pollination and egg come from different plants (a controlled breeding experiment)
Mendel's Study of Pea Plants
- Traits, or variants, are observable characteristics.
- A true-breeder produces the same trait over generations.
- Examples of pea plant traits include height, flower color, seed shape, and seed color.
Types of crosses
- Single factor crosses: involve two plants that differ in only one trait.
- The parental generation (P) is crossed to produce the first-generation (F1) offspring.
- The F1 plants self-fertilize to produce the second-generation (F2) offspring seeds.
Data from Single Factor Crosses
- Data on the results of various single factor crosses.
Interpreting the data
- Traits do not blend; one variant is dominant, the other recessive; this is observed in the F1 generation.
- Particulate theory of inheritance: traits are inherited as discrete units called "genes" that remain unchanged.
Law of Segregation
- Two copies of a gene separate during gamete formation.
- Each gamete carries one copy of each gene.
- "Alleles"—different forms of a gene.
- "Homozygous" = two identical alleles
- "Heterozygous" = two different alleles.
- "Genotype" = genetic makeup.
- "Phenotype" = observable traits.
Punnett Squares
- Used to predict the outcome of simple genetic crosses.
- Proposed by Reginald Punnett.
- Example of a cross between heterozygous tall plants (Tt x Tt).
Two Factor Crosses
- Involve crossing plants that differ in two traits.
- Example of traits: seed texture (round vs. wrinkled) and seed color (yellow vs. green)
- Two possible inheritance patterns:
- Linked assortment (genes close together on the same chromosome remain together during gamete formation),
- Independent assortment (genes are on separate chromosomes and segregate independently during gamete formation).
Data from Two-Factor Crosses
- Data from results of various two factor crosses, which showed patterns that were closer to expectations of independent assortment than linked assortment.
Law of Independent Assortment
- Different traits are independently inherited during gamete formation.
- Two factors assort independently during gamete formation.
Mendel's Law of Independent Assortment
- Genes are linked if they are on the same chromosome.
- Genetic recombination happens when the offspring receives a combination of alleles that differs from the parent generation due to:
- Independent assortment,
- Crossing over. Note crossing over is not in chapter 3.
Probability
- The probability an event will occur is the chance of it happening again in the future.
- Probability calculations are used to predicts results.
- Probability = Number of favorable outcomes/Total number of possible outcomes
Chi Square Test
- A statistical method to determine if there is a good fit between the data and hypothesis.
P Value
- The P-value is an important tool in statistics that measures the probability of observing results as extreme as, or more extreme than, the observed results, assuming the null hypothesis is true. A lower P-value suggests stronger evidence against the null hypothesis (supporting your desired outcome).
Modern Genetics
- Defective copies of genes are called 'loss-of-function alleles'.
- Loss-of-function alleles are commonly inherited recessively (the gene must be present on both allele copies.)
The Chromosome Theory of Inheritance
- Chromosomes carry the genetic material.
- Chromosomes are replicated and transmitted to offspring.
- Eukaryotic cell nuclei contain chromosomes in homologous pairs.
- During meiosis, homologs and different chromosome types segregate independently.
- Each parent provides one chromosome set to the offspring.
Pedigree Analysis
- Used to determine patterns of inheritance of traits in humans.
- Pedigrees demonstrate a family's inheritance of a genetic trait over generations.
- This can determine if a trait or disease is dominant or recessive.
- Genes that are related to diseases can exist as non-disease-causing alleles or as disease-causing mutant alleles.
Additional Information
- Concepts of product rule and binominal expansion are useful for probability calculations in genetics problems, especially when the genetic trait is expressed over multiple factors (multiple genes).
- Calculating the probability of a specific outcome (e.g. congenital analgesia in offspring).
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Description
Test your knowledge on Mendel's experiments and his fundamental contributions to genetics. This quiz covers Mendel's pea plant studies, types of crosses, and the characteristics of traits. Challenge yourself with questions about key concepts in inheritance patterns and genetic traits.