Podcast
Questions and Answers
In autosomal dominant inheritance, what is the likelihood that a child will inherit the disorder if one parent is affected and heterozygous?
In autosomal dominant inheritance, what is the likelihood that a child will inherit the disorder if one parent is affected and heterozygous?
- 75%
- 25%
- 100%
- 50% (correct)
Which of the following is NOT a characteristic of autosomal dominant inheritance?
Which of the following is NOT a characteristic of autosomal dominant inheritance?
- Affected individuals typically have an affected parent
- May skip generations due to sporadic mutations
- Each gamete carries one mutant and one normal allele
- Homozygous genotype is common and less severe (correct)
In the context of autosomal recessive inheritance, what must be true about the parents of an affected child?
In the context of autosomal recessive inheritance, what must be true about the parents of an affected child?
- Neither parent can pass on the recessive allele
- Parents must have a homozygous dominant genotype
- Both parents are carriers of the recessive mutant allele (correct)
- At least one parent must express the disorder
What might cause an autosomal dominant trait to appear in an individual without an affected parent?
What might cause an autosomal dominant trait to appear in an individual without an affected parent?
Which condition exemplifies autosomal dominant inheritance?
Which condition exemplifies autosomal dominant inheritance?
What does Mendelian inheritance primarily rely on?
What does Mendelian inheritance primarily rely on?
Which tool is best used to visualize the inheritance of a trait across generations?
Which tool is best used to visualize the inheritance of a trait across generations?
Which of the following best describes the laws governing Mendelian inheritance?
Which of the following best describes the laws governing Mendelian inheritance?
What is a primary characteristic of autosomal dominant disorders?
What is a primary characteristic of autosomal dominant disorders?
How can the recurrence risk of monogenic autosomal disorders be effectively calculated?
How can the recurrence risk of monogenic autosomal disorders be effectively calculated?
Flashcards
Mendelian Inheritance
Mendelian Inheritance
Inheritance of traits controlled by a single gene with two alleles, one potentially dominant over the other.
Autosomal Inheritance
Autosomal Inheritance
Inheritance patterns of traits controlled by genes on non-sex chromosomes (autosomes).
Pedigree
Pedigree
A chart illustrating family history and inheritance of traits.
Punnett Square
Punnett Square
Signup and view all the flashcards
Recurrence Risk
Recurrence Risk
Signup and view all the flashcards
Autosomal Dominant (AD) Inheritance
Autosomal Dominant (AD) Inheritance
Signup and view all the flashcards
New Mutation in AD Inheritance
New Mutation in AD Inheritance
Signup and view all the flashcards
Variable Expressivity in AD Inheritance
Variable Expressivity in AD Inheritance
Signup and view all the flashcards
Autosomal Recessive (AR) Inheritance
Autosomal Recessive (AR) Inheritance
Signup and view all the flashcards
Obligate Heterozygote Carrier
Obligate Heterozygote Carrier
Signup and view all the flashcards
Study Notes
Mendelian Inheritance
- Mendelian inheritance describes the inheritance of traits controlled by a single gene with two alleles.
- Autosomal inheritance refers to traits controlled by genes on autosomes (non-sex chromosomes).
- Sex-linked inheritance refers to traits controlled by genes on sex chromosomes.
- Mendelian inheritance follows the laws of segregation and independent assortment. Genes inherited from each parent segregate into gametes equally.
Studying Inheritance Patterns
- Pedigree: A chart that represents family history and relationships, using symbols.
- Shows relationships and identifies individuals with a trait.
- Shows how a trait is passed through generations.
- Determines the mode of inheritance (e.g., autosomal dominant, recessive, X-linked).
- Calculates risk of a trait for family members.
Autosomal Dominant Inheritance
- A trait that manifests in the heterozygous state (one abnormal allele and one normal allele).
- Affects males and females equally.
- Parents with the trait often pass it to their children.
- Vertical transmission of the trait through generations is common.
- Possible for affected individual to inherit mutant allele from new mutation.
- Affected children usually are heterozygotes.
Autosomal Recessive Inheritance
- Both alleles must be abnormal for the trait to manifest.
- Equally affects males and females.
- Often skips generations.
- Usually appears in children of unaffected parents who are carriers (heterozygotes).
- High chance of appearing when consanguineous (close blood relatives) mating occurs.
Studying That Suits You
Use AI to generate personalized quizzes and flashcards to suit your learning preferences.
