Membrane Transport Overview
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Questions and Answers

What primarily determines the movement of a nonpolar solute across a membrane?

  • Size of the molecule
  • Electrochemical potential
  • Concentration gradient (correct)
  • Presence of transport proteins
  • What is the role of carrier proteins in facilitated diffusion?

  • They generate electrochemical gradients.
  • They create hydrophobic barriers.
  • They form channels for ions to pass through.
  • They bind solutes and undergo conformational changes. (correct)
  • Why do polar substances, particularly ions, have low permeability across membranes?

  • They associate with water molecules, forming hydration shells. (correct)
  • They are too large to cross.
  • They require specific energy inputs.
  • They cannot form stable bonds with membrane lipids.
  • What keeps the concentration of glucose low inside animal cells?

    <p>Phosphorylation of glucose upon entry</p> Signup and view all the answers

    What characterizes facilitated diffusion as a transport process?

    <p>It involves the binding of solutes to transporter proteins.</p> Signup and view all the answers

    Which type of channel protein allows the rapid passage of ions across the membrane?

    <p>Ion channels</p> Signup and view all the answers

    What is the primary factor that influences the direction of glucose transport via GLUT1?

    <p>Solute concentrations inside and outside the cell</p> Signup and view all the answers

    How does simple diffusion differ from facilitated diffusion?

    <p>Facilitated diffusion requires transport proteins.</p> Signup and view all the answers

    What must be maintained across the plasma membrane for a cell to function?

    <p>Electrochemical potential</p> Signup and view all the answers

    Which statement about the anion exchange protein Band 3 is true?

    <p>It facilitates the exchange of Cl– and HCO3– ions.</p> Signup and view all the answers

    What type of molecules can typically diffuse through a lipid bilayer most easily?

    <p>Nonpolar substances</p> Signup and view all the answers

    What effect does solute concentration have on the process of diffusion?

    <p>It drives solutes towards equilibrium.</p> Signup and view all the answers

    Which characteristic of channel proteins aids in facilitating diffusion?

    <p>They create hydrophilic passages through the membrane.</p> Signup and view all the answers

    Which process would most likely occur if the concentration of a solute outside the cell is higher than inside?

    <p>Facilitated diffusion</p> Signup and view all the answers

    What defines the primary active transport mechanism?

    <p>Coupling of solute movement with ATP hydrolysis.</p> Signup and view all the answers

    Which type of ATPase is responsible for maintaining ion gradients across plasma membranes in eukaryotic cells?

    <p>P2-type ATPases</p> Signup and view all the answers

    What is the function of aquaporins in cell membranes?

    <p>Permitting rapid passage of water molecules.</p> Signup and view all the answers

    What distinguishes indirect active transport from direct active transport?

    <p>Coupling of the transport of one substance with another's gradient forces.</p> Signup and view all the answers

    Which of the following describes P-type ATPases?

    <p>Transporters that are reversibly phosphorylated by ATP.</p> Signup and view all the answers

    How do symport mechanisms in indirect active transport function?

    <p>They drive the movement of one solute up its gradient using another's down gradient.</p> Signup and view all the answers

    What is a major role of the Na+/K+ ATPase in animal cells?

    <p>Maintaining high intracellular potassium levels and low sodium levels.</p> Signup and view all the answers

    Which type of ion channel is opened by changes in membrane potential?

    <p>Voltage-gated channels</p> Signup and view all the answers

    What characterizes the structure of porins?

    <p>They have a b barrel with a hydrophilic central pore.</p> Signup and view all the answers

    What is a primary function of active transport mechanisms?

    <p>Uptake of essential nutrients against concentration gradients.</p> Signup and view all the answers

    How do ABC-type ATPases primarily function?

    <p>They bind ATP and couple its hydrolysis to transport across membranes.</p> Signup and view all the answers

    In the context of cell membrane transport, what does the term 'gated' refer to?

    <p>Channels that open and close in response to stimuli.</p> Signup and view all the answers

    What type of signal prompts ligand-gated channels to open?

    <p>Binding of specific molecules</p> Signup and view all the answers

    Study Notes

    Membrane Transport

    • Membranes are selectively permeable, meaning they control what enters and exits.
    • This selective permeability is crucial for cell function, allowing the cell to maintain the appropriate concentrations of molecules.

    Types of Transport

    • Simple diffusion: Small, nonpolar molecules move directly through the phospholipid bilayer from high to low concentration.
    • Facilitated diffusion: Large or polar molecules need transport proteins to move across the membrane, still following the concentration gradient.
    • Active transport: Movement against a concentration gradient, requiring energy (usually ATP).

    Solute Movement Factors

    • Size: Small molecules diffuse more easily than large ones.
    • Polarity: Nonpolar molecules cross lipid bilayers more readily than polar ones.
    • Charge: Polarity and charge hinder molecule transport through the hydrophobic interior of the lipid bilayer, water molecules form hydration shells around the solute.

    Channel Proteins

    • Ion channels: Form hydrophilic channels for specific ions (e.g., Na+, K+, Cl-).
    • Porins: Larger channels found in outer membranes (bacteria, mitochondria, chloroplasts).
    • Aquaporins: Specialized channels for water movement.
    • Gated channels: Regulated by stimuli: voltages (membrane potential), ligands (molecules binding to the channel), or mechanical forces.

    Carrier Proteins

    • Carrier proteins: Bind to molecules on one side of the membrane, change shape and release it on the other side. Follow the concentration gradient.
    • Uniport: One molecule moving in one direction
    • Symport: Two molecules moving in the same direction
    • Antiport: Two molecules moving in opposite directions

    Example of Specific Transporters

    • GLUT1: Glucose transporter - moves glucose into cells via facilitated diffusion
    • Na+/K+ ATPase: Moves Na+ out of the cell and K+ into the cell, requires ATP energy.
    • Anion exchange protein (Band 3): Exchanges chloride and bicarbonate ions.

    Active Transport Mechanisms

    • Primary active transport: Directly uses ATP for the transport of a molecule. Requires a protein transporter.
    • P-type ATPases: Phosphorylated by ATP, transport ions. E.g., Na+/K+ pump.
    • V-type ATPases: Pump protons into organelles (vacuoles, lysosomes)
    • F-type ATPases: Transport protons, can also synthesize ATP (known as ATP synthases).
    • ABC-type ATPases: Transport a wide variety of molecules; have two binding sites for ATP, important in pumping drugs out of cells.

    Indirect Active Transport

    • Secondary Active transport: Movement of one substance down its gradient supplies the energy for movement of another substance against its gradient
    • Requires a driving force established by the primary active transport pump.

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    Description

    Explore the concept of membrane transport and how cells regulate the entry and exit of substances. This quiz covers various types of transport mechanisms, including simple diffusion, facilitated diffusion, and active transport, as well as the factors influencing solute movement.

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