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Membrane Proteins Overview

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Questions and Answers

What is the mechanism of action of Phospholipase A2?

Bind to negatively charged phospholipids inducing a conformational change (correct)

Break ionic and hydrogen bonds with its charge

Solubilize membrane proteins by interacting with water

Interact with hydrocarbons due to its hydrophilic part

Which type of detergent can denature proteins?

Ionic detergents (correct)

Non-ionic detergents

Hydrophobic detergents

Amphipathic detergents

What is the role of calcium in the catalysis of Phospholipase A2?

Interacts with hydrocarbons

Binds to negatively charged phospholipids

Positions the ester bond for cleavage (correct)

Induces a conformational change in the enzyme

Which type of detergent lacks a charged group?

Non-ionic detergents Signup and view all the answers

What type of membrane proteins contain membrane spanning α-helices?

Integral membrane proteins Signup and view all the answers

Which type of membrane protein has hydrophobic side chains interacting with fatty acyl groups?

Integral membrane proteins Signup and view all the answers

Which type of membrane proteins are responsible for antigen recognition in the T cell receptor?

Alpha-beta pair Signup and view all the answers

How many membrane-spanning helices does the bacterial protein Rhodopsin have?

7 Signup and view all the answers

What is the structure of Aquaporin 0?

Homotetramer Signup and view all the answers

Where are porins typically found?

Outer membrane of Gram-negative bacteria, mitochondria, and chloroplasts Signup and view all the answers

What type of side chains line the pore of the transmembrane protein described in the text?

Hydrophilic Signup and view all the answers

Which type of anchors are attached to the N-terminus of cytosolic proteins like v-src for membrane anchoring?

Fatty acyl groups Signup and view all the answers

What is the name of the hydrocarbon chains attached to cysteine residues near the C-terminus for membrane anchoring?

Farnesyl and geranylgeranyl Signup and view all the answers

Which type of anchors are mentioned in the text as exoplasmic anchors for glycoproteins?

GPI anchors Signup and view all the answers