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Questions and Answers
What is the primary use of donepezil?
What is the primary use of donepezil?
- Treating overdoses of atropine
- Treating Alzheimer’s disease (correct)
- Treating myasthenia gravis
- Enhancing memory in multiple sclerosis
Where does metabolism of donepezil take place?
Where does metabolism of donepezil take place?
- Lungs
- Stomach
- Kidneys
- Liver (correct)
What is the peak of action time for donepezil?
What is the peak of action time for donepezil?
- 3 to 8 hours (correct)
- 10 to 12 hours
- 24 hours
- 1 to 2 hours
How is absorption of donepezil affected by food?
How is absorption of donepezil affected by food?
What does donepezil do to acetylcholine levels in the brain?
What does donepezil do to acetylcholine levels in the brain?
What percentage of donepezil is bound to plasma proteins?
What percentage of donepezil is bound to plasma proteins?
For how long has long-term studies shown that donepezil delays the progression of Alzheimer’s disease?
For how long has long-term studies shown that donepezil delays the progression of Alzheimer’s disease?
In addition to Alzheimer’s disease, what other condition can donepezil be used to enhance memory?
In addition to Alzheimer’s disease, what other condition can donepezil be used to enhance memory?
What is the main route of excretion for donepezil and its metabolites?
What is the main route of excretion for donepezil and its metabolites?
What effect does donepezil have on the neuronal degradation in Alzheimer’s disease?
What effect does donepezil have on the neuronal degradation in Alzheimer’s disease?
Which age group is more susceptible to adverse drug effects due to age-related physiological changes and underlying health conditions?
Which age group is more susceptible to adverse drug effects due to age-related physiological changes and underlying health conditions?
What can impair the hepatic metabolism of donepezil, leading to increased adverse effects?
What can impair the hepatic metabolism of donepezil, leading to increased adverse effects?
In which population is donepezil used to reduce cognitive dysfunction, particularly in critically ill patients with delirium?
In which population is donepezil used to reduce cognitive dysfunction, particularly in critically ill patients with delirium?
What is a common adverse effect of donepezil?
What is a common adverse effect of donepezil?
What are the contraindications to donepezil?
What are the contraindications to donepezil?
Which of the following can interact with donepezil, either increasing or decreasing its effects?
Which of the following can interact with donepezil, either increasing or decreasing its effects?
When should nurses administer donepezil?
When should nurses administer donepezil?
What should nurses be cautious about regarding brand name confusion?
What should nurses be cautious about regarding brand name confusion?
What should nurses assess for in patients receiving donepezil?
What should nurses assess for in patients receiving donepezil?
What drug is similar to donepezil, indicated for mild to moderate dementia and vascular dementia?
What drug is similar to donepezil, indicated for mild to moderate dementia and vascular dementia?
What is the primary use of rivastigmine?
What is the primary use of rivastigmine?
How long does oral rivastigmine last, allowing for dosing?
How long does oral rivastigmine last, allowing for dosing?
Where does the metabolism of rivastigmine occur?
Where does the metabolism of rivastigmine occur?
What is the primary use of memantine?
What is the primary use of memantine?
How does memantine act to prevent nerve damage?
How does memantine act to prevent nerve damage?
What is a contraindication for memantine?
What is a contraindication for memantine?
How should the extended-release formulation of memantine be taken?
How should the extended-release formulation of memantine be taken?
What should caregivers be vigilant for when administering memantine?
What should caregivers be vigilant for when administering memantine?
What does memantine interact with, affecting its serum concentration?
What does memantine interact with, affecting its serum concentration?
How is the transdermal form of rivastigmine administered?
How is the transdermal form of rivastigmine administered?
What is the primary purpose of rivastigmine in treating Alzheimer's disease?
What is the primary purpose of rivastigmine in treating Alzheimer's disease?
How long does the oral form of rivastigmine last, allowing for dosing twice a day?
How long does the oral form of rivastigmine last, allowing for dosing twice a day?
Where does rivastigmine's metabolism occur?
Where does rivastigmine's metabolism occur?
What is the mechanism of action of memantine in treating Alzheimer's disease?
What is the mechanism of action of memantine in treating Alzheimer's disease?
What is a contraindication for memantine use?
What is a contraindication for memantine use?
How should the extended-release formulation of memantine be taken?
How should the extended-release formulation of memantine be taken?
What should caregivers be vigilant for when administering memantine?
What should caregivers be vigilant for when administering memantine?
Which medication is also used to treat Parkinson's disease?
Which medication is also used to treat Parkinson's disease?
How does the transdermal form of rivastigmine differ from the oral form?
How does the transdermal form of rivastigmine differ from the oral form?
What is the excretion route of rivastigmine?
What is the excretion route of rivastigmine?
What is the primary use of donepezil?
What is the primary use of donepezil?
How does donepezil affect acetylcholine levels in the brain?
How does donepezil affect acetylcholine levels in the brain?
Where does metabolism of donepezil take place?
Where does metabolism of donepezil take place?
What should nurses assess for in patients receiving donepezil?
What should nurses assess for in patients receiving donepezil?
What is a contraindication for using donepezil?
What is a contraindication for using donepezil?
What is the primary use of galantamine hydrobromide in treating dementia?
What is the primary use of galantamine hydrobromide in treating dementia?
How long does the peak action of extended-release memantine occur?
How long does the peak action of extended-release memantine occur?
What is the primary route of excretion for rivastigmine and its metabolites?
What is the primary route of excretion for rivastigmine and its metabolites?
What is the primary mechanism of action of memantine in preventing nerve damage?
What is the primary mechanism of action of memantine in preventing nerve damage?
How long does oral rivastigmine last, allowing for dosing?
How long does oral rivastigmine last, allowing for dosing?
What is the main route of excretion for rivastigmine and its metabolites?
What is the main route of excretion for rivastigmine and its metabolites?
What is the peak action time for memantine with extended-release formulation?
What is the peak action time for memantine with extended-release formulation?
What is the primary mechanism of action of memantine in treating Alzheimer's disease?
What is the primary mechanism of action of memantine in treating Alzheimer's disease?
What is a contraindication for rivastigmine use?
What is a contraindication for rivastigmine use?
Study Notes
Alzheimer's Disease Medications: Rivastigmine and Memantine
- Rivastigmine is a cholinesterase inhibitor used to treat mild to moderate dementia due to Alzheimer's disease and Parkinson's disease.
- It is not a cure for Alzheimer's disease but helps slow the progression of symptoms.
- Oral rivastigmine lasts 12 hours, allowing for twice-a-day dosing, while the transdermal form is applied as a patch once a day.
- Rivastigmine's metabolism occurs in the liver, and it is excreted in the feces.
- Memantine is an NMDA receptor antagonist used to slow the progression of moderate to severe Alzheimer's disease.
- It is well absorbed orally, with 100% absorption in the GI tract, and easily crosses the blood-brain barrier.
- Memantine's peak action occurs 3 to 7 hours with immediate-release and 9 to 12 hours with extended-release formulation.
- Memantine acts by binding to the magnesium site to block excitatory function, slowing intracellular calcium accumulation and preventing nerve damage.
- Memantine is contraindicated in patients with hypersensitivity reactions or renal failure.
- It interacts with carbonic anhydrase, alkalinizing agents, and trimethoprim, affecting its serum concentration.
- Memantine should be administered without regard to meals, and the extended-release formulation should be swallowed whole.
- Caregivers need to be educated about memantine administration and be vigilant for adverse effects such as changes in blood pressure, CNS effects, and signs of hypersensitivity reactions.
Alzheimer's Disease Medications: Rivastigmine and Memantine
- Rivastigmine is a cholinesterase inhibitor used to treat mild to moderate dementia due to Alzheimer's disease and Parkinson's disease.
- It is not a cure for Alzheimer's disease but helps slow the progression of symptoms.
- Oral rivastigmine lasts 12 hours, allowing for twice-a-day dosing, while the transdermal form is applied as a patch once a day.
- Rivastigmine's metabolism occurs in the liver, and it is excreted in the feces.
- Memantine is an NMDA receptor antagonist used to slow the progression of moderate to severe Alzheimer's disease.
- It is well absorbed orally, with 100% absorption in the GI tract, and easily crosses the blood-brain barrier.
- Memantine's peak action occurs 3 to 7 hours with immediate-release and 9 to 12 hours with extended-release formulation.
- Memantine acts by binding to the magnesium site to block excitatory function, slowing intracellular calcium accumulation and preventing nerve damage.
- Memantine is contraindicated in patients with hypersensitivity reactions or renal failure.
- It interacts with carbonic anhydrase, alkalinizing agents, and trimethoprim, affecting its serum concentration.
- Memantine should be administered without regard to meals, and the extended-release formulation should be swallowed whole.
- Caregivers need to be educated about memantine administration and be vigilant for adverse effects such as changes in blood pressure, CNS effects, and signs of hypersensitivity reactions.
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Description
Test your knowledge on Alzheimer's disease medications and their dosage information with this quiz. Explore the uses, adverse effects, contraindications, and administration guidelines for drugs like donepezil, rivastigmine, memantine, and galantamine hydrobromide. Ideal for nurses, caregivers, and healthcare professionals involved in the management of Alzheimer's disease.
