Medicinal Chemistry: Physicochemical Parameters and Biological Activity
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Questions and Answers

Which of the following is NOT a reason why the distomer (unwanted stereoisomer) should be considered an impurity?

  • It may cause side effects
  • It may be metabolized to a compound with unfavorable activity
  • It may be more potent than the eutomer (correct)
  • It may counteract the pharmacological action of the eutomer (desired stereoisomer)

    • What is the main purpose of the text?

  • To explain the synthesis and pharmacology of various medications
  • To compare the properties of different drug stereoisomers
  • To discuss biological activity and physicochemical parameters of drugs (correct)
  • To provide an overview of drug metabolism and isosterism

    • What is the relationship between (R)-carvone and (S)-carvone?

  • They are constitutional isomers
  • They are diastereomers
  • They are enantiomers (correct)
  • They are structural isomers

    • In the case of ibuprofen, what happens to the R-enantiomer in vivo?

    <p>It is converted to the S-enantiomer</p> Signup and view all the answers

    What is the definition of isosterism according to the text?

    <p>Two molecules or fragments with the same number and arrangement of electrons</p> Signup and view all the answers

    Which of the following pairs of functional groups are considered isosteres according to the text?

    <p>All of the above</p> Signup and view all the answers

    What is the definition of classical bioisosteres according to the text?

    <p>Compounds or groups that possess similar molecular shapes, volumes, and electronic distributions</p> Signup and view all the answers

    Which of the following is classified as a bivalent classical bioisostere according to the text?

    <p>RSER</p> Signup and view all the answers

    Which of the following is classified as a tetravalent classical bioisostere according to the text?

    <p>All of the above</p> Signup and view all the answers

    What is the primary purpose of using classical bioisosteres in drug design?

    <p>To modify the biological activity of a drug molecule</p> Signup and view all the answers

    Which of the following is NOT an example of a univalent classical bioisostere according to the text?

    <p>NH₂</p> Signup and view all the answers

    Which of the following groups are considered trivalent classical bioisosteres?

    <p>Both a and c</p> Signup and view all the answers

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