Podcast
Questions and Answers
Which of the following is NOT a reason why the distomer (unwanted stereoisomer) should be considered an impurity?
Which of the following is NOT a reason why the distomer (unwanted stereoisomer) should be considered an impurity?
- It may cause side effects
- It may be metabolized to a compound with unfavorable activity
- It may be more potent than the eutomer (correct)
- It may counteract the pharmacological action of the eutomer (desired stereoisomer)
What is the main purpose of the text?
What is the main purpose of the text?
- To explain the synthesis and pharmacology of various medications
- To compare the properties of different drug stereoisomers
- To discuss biological activity and physicochemical parameters of drugs (correct)
- To provide an overview of drug metabolism and isosterism
What is the relationship between (R)-carvone and (S)-carvone?
What is the relationship between (R)-carvone and (S)-carvone?
- They are constitutional isomers
- They are diastereomers
- They are enantiomers (correct)
- They are structural isomers
In the case of ibuprofen, what happens to the R-enantiomer in vivo?
In the case of ibuprofen, what happens to the R-enantiomer in vivo?
What is the definition of isosterism according to the text?
What is the definition of isosterism according to the text?
Which of the following pairs of functional groups are considered isosteres according to the text?
Which of the following pairs of functional groups are considered isosteres according to the text?
What is the definition of classical bioisosteres according to the text?
What is the definition of classical bioisosteres according to the text?
Which of the following is classified as a bivalent classical bioisostere according to the text?
Which of the following is classified as a bivalent classical bioisostere according to the text?
Which of the following is classified as a tetravalent classical bioisostere according to the text?
Which of the following is classified as a tetravalent classical bioisostere according to the text?
What is the primary purpose of using classical bioisosteres in drug design?
What is the primary purpose of using classical bioisosteres in drug design?
Which of the following is NOT an example of a univalent classical bioisostere according to the text?
Which of the following is NOT an example of a univalent classical bioisostere according to the text?
Which of the following groups are considered trivalent classical bioisosteres?
Which of the following groups are considered trivalent classical bioisosteres?
