12 Questions
Which of the following is NOT a reason why the distomer (unwanted stereoisomer) should be considered an impurity?
It may be more potent than the eutomer
What is the main purpose of the text?
To discuss biological activity and physicochemical parameters of drugs
What is the relationship between (R)-carvone and (S)-carvone?
They are enantiomers
In the case of ibuprofen, what happens to the R-enantiomer in vivo?
It is converted to the S-enantiomer
What is the definition of isosterism according to the text?
Two molecules or fragments with the same number and arrangement of electrons
Which of the following pairs of functional groups are considered isosteres according to the text?
All of the above
What is the definition of classical bioisosteres according to the text?
Compounds or groups that possess similar molecular shapes, volumes, and electronic distributions
Which of the following is classified as a bivalent classical bioisostere according to the text?
RSER
Which of the following is classified as a tetravalent classical bioisostere according to the text?
All of the above
What is the primary purpose of using classical bioisosteres in drug design?
To modify the biological activity of a drug molecule
Which of the following is NOT an example of a univalent classical bioisostere according to the text?
NH₂
Which of the following groups are considered trivalent classical bioisosteres?
Both a and c
Explore the relationship between physicochemical parameters and biological activity in medicinal chemistry. Learn about the metabolic inversion of enantiomers in drugs like Ibuprofen and the significance of different isomers in pharmaceutical activity.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
