Medicinal Chemistry-I Quiz
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Questions and Answers

What is the total number of credit hours for the first two weeks of the course?

  • 4 hours (correct)
  • 8 hours
  • 6 hours
  • 2 hours

    • How many topics are covered in the β-Lactam antibiotics segment?

  • 2 topics (correct)
  • 3 topics
  • 4 topics
  • 1 topic

    • Which of the following drug classes is being introduced during week 5?

  • Macrolides
  • Tetracyclines
  • Cephalosporins (correct)
  • Aminoglycosides

    • Which activity is scheduled during week 10?

    <p>Case study</p> Signup and view all the answers

    What is one of the new components introduced during the introduction of antiviral agents?

    <p>Case study</p> Signup and view all the answers

    What is the primary focus of pharmaceutical care according to the provided information?

    <p>Prescribe therapeutic recommendations based on drug chemistry</p> Signup and view all the answers

    Which ability is emphasized for professionals in personal practice?

    <p>Enhancing creativity and managing time effectively</p> Signup and view all the answers

    What should effective communication in medicinal chemistry include?

    <p>Proper scientific language in both verbal and written forms</p> Signup and view all the answers

    What kind of technologies should be utilized in healthcare services according to the information?

    <p>Artificial technologies for delivering information</p> Signup and view all the answers

    What aspect of professional development is highlighted in the content?

    <p>Developing strategies to enhance learning needs</p> Signup and view all the answers

    Which of the following best describes the primary objective of medicinal chemistry?

    <p>To identify relationships between chemical structures and biological activities</p> Signup and view all the answers

    What is one of the key outcomes for students completing the Medicinal Chemistry-I course?

    <p>Understanding the different modes of action of anticancer agents</p> Signup and view all the answers

    Which principle is applied to evaluate the activity of chemotherapeutic agents?

    <p>Structural activity relationship</p> Signup and view all the answers

    What is an essential ethical practice in the field of medicinal chemistry?

    <p>Detecting side effects and toxicity based on drug structure</p> Signup and view all the answers

    Which method is included in the course principles for designing new molecular entities?

    <p>Computer-aided tools and molecular modeling</p> Signup and view all the answers

    What type of knowledge should students develop related to drug production in medicinal chemistry?

    <p>Practical and applied knowledge about drug production</p> Signup and view all the answers

    In the context of drug development principles, which approach is encouraged?

    <p>Systematic approaches adapting medicinal chemistry principles</p> Signup and view all the answers

    What is the relationship that students should recognize regarding chemotherapeutic drugs?

    <p>Chemical structure and therapeutic activity</p> Signup and view all the answers

    What is the primary focus of medicinal chemistry?

    <p>The discovery and design of new agents to treat diseases</p> Signup and view all the answers

    Which method is used to assess students' understanding in the 4th and 10th weeks?

    <p>Personal/Team based learning (TBL)</p> Signup and view all the answers

    What percentage of the final grade does the Written Exam contribute?

    <p>50%</p> Signup and view all the answers

    Which of the following is NOT evaluated by the midterm exam?

    <p>Understanding of pharmacodynamics</p> Signup and view all the answers

    Which element is part of the pharmacokinetics process as related to medicinal chemistry?

    <p>Absorption</p> Signup and view all the answers

    What is assessed during class activities such as discussions or presentations?

    <p>Transferable skills</p> Signup and view all the answers

    What does ADME stand for in pharmacokinetics?

    <p>Absorption, Distribution, Metabolism, Excretion</p> Signup and view all the answers

    Which activity is part of the course schedule to assess student understanding?

    <p>Quizzes</p> Signup and view all the answers

    Which statement correctly describes acidic functional groups in drugs?

    <p>They donate protons to produce hydronium ions.</p> Signup and view all the answers

    What defines a basic drug according to the Bronsted-Lowery theory?

    <p>It accepts protons from water.</p> Signup and view all the answers

    Which part of the drug structure is primarily hydrophilic?

    <p>Hetero-atoms and functional groups</p> Signup and view all the answers

    Which of the following would decrease the acidity of benzoic acid?

    <p>Adding halogen atoms.</p> Signup and view all the answers

    Which phase in pharmacokinetics involves the interaction of the drug with its site of action?

    <p>Pharmacodynamic phase</p> Signup and view all the answers

    What effect do electron withdrawing groups have on drug compounds?

    <p>They stabilize the ionized form.</p> Signup and view all the answers

    Which of the following is NOT a component of the pharmacokinetic phase?

    <p>Pharmacodynamics</p> Signup and view all the answers

    Halogen atoms such as F, Cl, Br, or I are characterized by which of the following properties?

    <p>They have no significant interactions with water.</p> Signup and view all the answers

    What is the First Pass Effect in drug metabolism?

    <p>The metabolic alteration of a drug by liver enzymes before reaching systemic circulation.</p> Signup and view all the answers

    Which phase involves the interaction of a drug with its receptor?

    <p>Pharmacodynamic phase</p> Signup and view all the answers

    What is the pharmacophore of a drug?

    <p>The structural unit essential for receptor interaction.</p> Signup and view all the answers

    What does the Structure-Activity Relationship (SAR) indicate?

    <p>The relationship between chemical structure and biological activity.</p> Signup and view all the answers

    Which property is considered crucial in determining drug activity?

    <p>Acid/base properties</p> Signup and view all the answers

    Intrinsic activity in pharmacology refers to what?

    <p>The ability of the drug-receptor complex to elicit a biological effect.</p> Signup and view all the answers

    Which of the following best describes affinity?

    <p>The ability of a drug to interact with a receptor.</p> Signup and view all the answers

    Study Notes

    Course Information

    • Course Title: Medicinal Chemistry-I
    • Course Code: PMC-306
    • Program: Pharm D Program
    • Lecturer: Dr. Amal El-Masry
    • Department: Medicinal Chemistry Department
    • Office Hours: Monday (9.0 AM – 3.0 PM)
    • Course Description: According to the By-law

    Aims & Objectives

    • Identify the principles of medicinal chemistry
    • Recognize the relationships between the chemical structures of different chemotherapeutic drugs and biological activities
    • Understand the different modes of action of different classes of anticancer agents

    Course Learning Outcomes (Domain 1 - Fundamental Knowledge)

    • Recognize in-depth knowledge of medicinal chemistry as one of the applied pharmaceutical sciences
    • Manipulate knowledge to provide information about drug production and proper use
    • Discuss the mode of action and therapeutic uses of chemotherapeutic agents and anticancer drugs

    Course Learning Outcomes (Domain 2 - Professional and Ethical Practice)

    • Adapt medicinal chemistry principles to systemic drug development approaches
    • Apply structural activity relationships to evaluate the activity of chemotherapeutic agents based on structural similarities
    • Apply bioinformatics and modeling programs in designing new molecular entities
    • Detect possible side effects and toxicity of drug molecules based on structural features
    • Utilize scientific principles for research and evidence-based approaches

    Course Learning Outcomes (Domain 3 - Pharmaceutical Care)

    • Counsel patients on proper antibiotic use based on drug chemistry, pharmacodynamics and possible side effects

    Course Learning Outcomes (Domain 4 - Personal Practice)

    • Gather and analyze data independently and collaboratively with drug chemistry experts
    • Participate in healthcare service delivery and contribute to pharmacy knowledge
    • Communicate effectively using scientific language in the field of medicinal chemistry
    • Employ technology to deliver information effectively
    • Utilize ongoing professional development concepts

    Course Content

    • Introductory lecture - Physico-chemical properties of drug action
    • Beta-lactam antibiotics (Penicillins)
    • Beta-lactam antibiotics (Cephalosporins)
    • Macrolides + Tetracyclines
    • Sulfonamides + Dihydrofolate reductase inhibitors
    • Aminoglycosides
    • Other Agents (Chloramphenicol, Antimycobacterial Agents, Antileprotics, Antiseptic agents, Anti-fungal agents)
    • Antiviral drugs
    • Antineoplastic drugs

    Teaching and Learning Methods

    • Computer-aided learning (online learning, interactive discussions, presentations)
    • Self-learning (quizzes)
    • Class activities (discussion, brainstorming)
    • Case studies, posters, presentations

    Student Assessment

    • Midterm Exam (MCQs): 20% (8th week)
    • Written Exam (MCQs): 50% (16th, 17th week)
    • Semester work (Activity 1 and 2): 30% (4th, 10th week)

    Important Definitions

    • Pharmacophore: A structural unit in a drug essential for receptor interaction
    • Structure-Activity Relationship (SAR): The relationship between the chemical structure of a drug and its biological activity
    • Affinity: The ability of a drug to interact with a receptor
    • Intrinsic Activity (Efficacy): The ability of a drug-receptor complex to produce a biological effect

    Physicochemical Properties of Drugs

    • Acid/base properties
    • Hydrophilic/lipophilic properties (water and lipid solubility)
    • Electronic effect of substituents
    • Steric effect of substituents

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    Related Documents

    New Mansoura University Medicinal Chemistry Lecture PDF

    Description

    Test your knowledge on Medicinal Chemistry-I with this comprehensive quiz. Covering essential topics such as credit hours, drug classes, and pharmaceutical care, this quiz will challenge your understanding of the course material. Perfect for students wanting to assess their learning progress in this subject area.

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