Podcast
Questions and Answers
Which of the following treatments is an effective antiviral for herpes zoster?
Which of the following treatments is an effective antiviral for herpes zoster?
- Salicylic acid
- Methotrexate
- Acyclovir (correct)
- Nystatin
What is the mechanism of action for salicylic acid in the treatment of common warts?
What is the mechanism of action for salicylic acid in the treatment of common warts?
- Causes tissue necrosis
- Acts as a keratolytic agent (correct)
- Inhibits viral DNA polymerase
- Binds to ergosterol
Which medication is NOT typically used to manage candidiasis?
Which medication is NOT typically used to manage candidiasis?
- Clotrimazole
- Nystatin
- Fluconazole
- Valacyclovir (correct)
In the management of Stevens-Johnson Syndrome, what is the first step?
In the management of Stevens-Johnson Syndrome, what is the first step?
What is a requirement for generic drugs to ensure they are therapeutic equivalents to brand-name drugs?
What is a requirement for generic drugs to ensure they are therapeutic equivalents to brand-name drugs?
What is the primary mechanism of action for Efinaconazole in the treatment of toenail fungus?
What is the primary mechanism of action for Efinaconazole in the treatment of toenail fungus?
Which drug is classified as a short-acting beta agonist (SABA) for asthma?
Which drug is classified as a short-acting beta agonist (SABA) for asthma?
Which factor does NOT influence drug metabolism?
Which factor does NOT influence drug metabolism?
What is the mechanism of action for Terbinafine in treating toenail fungus?
What is the mechanism of action for Terbinafine in treating toenail fungus?
Which treatment is used for maintaining asthma control over time?
Which treatment is used for maintaining asthma control over time?
What characterizes Chronic Obstructive Pulmonary Disease (COPD)?
What characterizes Chronic Obstructive Pulmonary Disease (COPD)?
Which of the following statements regarding therapeutic drug monitoring (TDM) is true?
Which of the following statements regarding therapeutic drug monitoring (TDM) is true?
Which long-acting bronchodilator is used in the management of COPD?
Which long-acting bronchodilator is used in the management of COPD?
What factor significantly affects the bioavailability of a drug following oral administration?
What factor significantly affects the bioavailability of a drug following oral administration?
Which CYP450 enzyme is known to metabolize more than 50% of drugs?
Which CYP450 enzyme is known to metabolize more than 50% of drugs?
What is a common adverse effect associated with the use of steroids?
What is a common adverse effect associated with the use of steroids?
Which treatment is appropriate for bacterial conjunctivitis?
Which treatment is appropriate for bacterial conjunctivitis?
What is the primary mechanism behind fluoroquinolone-associated tendon rupture?
What is the primary mechanism behind fluoroquinolone-associated tendon rupture?
In the treatment of active tuberculosis, which drug inhibits RNA polymerase?
In the treatment of active tuberculosis, which drug inhibits RNA polymerase?
What is the typical treatment duration for latent tuberculosis with isoniazid?
What is the typical treatment duration for latent tuberculosis with isoniazid?
Which of the following drugs is often given with levodopa to enhance its bioavailability?
Which of the following drugs is often given with levodopa to enhance its bioavailability?
Which of the following medications is commonly used to manage pain associated with shingles?
Which of the following medications is commonly used to manage pain associated with shingles?
What is the primary mechanism of action for nystatin in the treatment of oral thrush?
What is the primary mechanism of action for nystatin in the treatment of oral thrush?
Which of the following medications is NOT typically used in the treatment of severe psoriasis?
Which of the following medications is NOT typically used in the treatment of severe psoriasis?
Which of the following is a key concern regarding generic drugs?
Which of the following is a key concern regarding generic drugs?
Which of the following best describes the cause of Stevens-Johnson Syndrome?
Which of the following best describes the cause of Stevens-Johnson Syndrome?
What is the primary reason for the reduced oral bioavailability of propranolol?
What is the primary reason for the reduced oral bioavailability of propranolol?
Which of the following statements about CYP450 enzymes is true?
Which of the following statements about CYP450 enzymes is true?
What adverse effect is commonly associated with the use of long-term corticosteroids?
What adverse effect is commonly associated with the use of long-term corticosteroids?
Which drug is used in the treatment of bacterial conjunctivitis?
Which drug is used in the treatment of bacterial conjunctivitis?
What mechanism leads to fluoroquinolone-associated tendon rupture?
What mechanism leads to fluoroquinolone-associated tendon rupture?
What is the typical treatment for active tuberculosis?
What is the typical treatment for active tuberculosis?
Which of the following options are risk factors for fluoroquinolone-associated tendon rupture?
Which of the following options are risk factors for fluoroquinolone-associated tendon rupture?
For treating latent tuberculosis, which medication is used for 6-9 months?
For treating latent tuberculosis, which medication is used for 6-9 months?
Which of the following medications is used to treat toenail fungus and inhibits squalene epoxidase, an enzyme essential for ergosterol synthesis?
Which of the following medications is used to treat toenail fungus and inhibits squalene epoxidase, an enzyme essential for ergosterol synthesis?
In managing patients with asthma, which of the following medications inhibits leukotriene receptors, reducing inflammation and bronchoconstriction, thereby contributing to maintenance therapy?
In managing patients with asthma, which of the following medications inhibits leukotriene receptors, reducing inflammation and bronchoconstriction, thereby contributing to maintenance therapy?
Which of the following conditions is NOT considered a factor influencing drug metabolism?
Which of the following conditions is NOT considered a factor influencing drug metabolism?
For patients with COPD, which of the following medications blocks muscarinic receptors, reducing bronchoconstriction and helping to improve airflow?
For patients with COPD, which of the following medications blocks muscarinic receptors, reducing bronchoconstriction and helping to improve airflow?
Which of the following medications is a short-acting beta-2 agonist (SABA) used for rescue therapy in asthma patients, providing immediate relief from bronchospasm?
Which of the following medications is a short-acting beta-2 agonist (SABA) used for rescue therapy in asthma patients, providing immediate relief from bronchospasm?
A patient is being treated for a severe case of asthma. Which of the following medications is MOST likely to be prescribed as maintenance therapy to reduce airway inflammation?
A patient is being treated for a severe case of asthma. Which of the following medications is MOST likely to be prescribed as maintenance therapy to reduce airway inflammation?
Why is therapeutic drug monitoring (TDM) particularly important for medications with a narrow therapeutic index?
Why is therapeutic drug monitoring (TDM) particularly important for medications with a narrow therapeutic index?
Which of the following correctly pairs a medication used to treat toenail fungus with its mechanism of action?
Which of the following correctly pairs a medication used to treat toenail fungus with its mechanism of action?
A patient with a painful, dermatomal rash is diagnosed with shingles. Which of the following drug mechanisms is MOST appropriate for addressing the underlying viral cause?
A patient with a painful, dermatomal rash is diagnosed with shingles. Which of the following drug mechanisms is MOST appropriate for addressing the underlying viral cause?
A patient's liver function is impaired. How does this most likely affect drug metabolism?
A patient's liver function is impaired. How does this most likely affect drug metabolism?
Which of the following describes the mechanism of action of a topical azole antifungal medication used in vaginal candidiasis?
Which of the following describes the mechanism of action of a topical azole antifungal medication used in vaginal candidiasis?
Which of the following is NOT a primary characteristic of the pathophysiology of asthma?
Which of the following is NOT a primary characteristic of the pathophysiology of asthma?
Which medication used for asthma maintenance therapy works by blocking leukotriene receptors?
Which medication used for asthma maintenance therapy works by blocking leukotriene receptors?
A patient is prescribed a generic drug. What bioequivalence parameter must this generic drug meet to be considered therapeutically equivalent to the brand-name product?
A patient is prescribed a generic drug. What bioequivalence parameter must this generic drug meet to be considered therapeutically equivalent to the brand-name product?
In the treatment of a common wart, cryotherapy is used to destroy the wart tissue. Which of the following mechanisms is primarily responsible for its effect?
In the treatment of a common wart, cryotherapy is used to destroy the wart tissue. Which of the following mechanisms is primarily responsible for its effect?
Which of the following best describes the primary mechanism of action of long-acting muscarinic antagonists (LAMAs) like Tiotropium used in COPD?
Which of the following best describes the primary mechanism of action of long-acting muscarinic antagonists (LAMAs) like Tiotropium used in COPD?
Why might a patient taking Warfarin require regular therapeutic drug monitoring (TDM)?
Why might a patient taking Warfarin require regular therapeutic drug monitoring (TDM)?
A patient develops Stevens-Johnson Syndrome after starting a new medication. Which immediate action is MOST critical in managing this condition?
A patient develops Stevens-Johnson Syndrome after starting a new medication. Which immediate action is MOST critical in managing this condition?
Which of these medications used for COPD acts as a beta-2 adrenergic receptor agonist?
Which of these medications used for COPD acts as a beta-2 adrenergic receptor agonist?
A patient is using both inhaled corticosteroids (ICS) and long-acting beta agonists (LABAs) for asthma maintenance. What is the primary benefit of combining these two treatments?
A patient is using both inhaled corticosteroids (ICS) and long-acting beta agonists (LABAs) for asthma maintenance. What is the primary benefit of combining these two treatments?
What is the primary reason why carbidopa is administered alongside levodopa?
What is the primary reason why carbidopa is administered alongside levodopa?
Which of the following best describes the mechanism of action for rifampin in the treatment of tuberculosis?
Which of the following best describes the mechanism of action for rifampin in the treatment of tuberculosis?
A patient presents with itchy, watery eyes. Which of the following would be the MOST appropriate initial treatment?
A patient presents with itchy, watery eyes. Which of the following would be the MOST appropriate initial treatment?
What is a significant risk associated with the use of fluoroquinolones, especially in older populations and those with certain co-morbidities?
What is a significant risk associated with the use of fluoroquinolones, especially in older populations and those with certain co-morbidities?
A patient on a drug metabolized by CYP3A4 starts taking fluoxetine. What potential effect could this combination have on the levels of the first drug?
A patient on a drug metabolized by CYP3A4 starts taking fluoxetine. What potential effect could this combination have on the levels of the first drug?
Which of the following statements best describes the use and action of topical corticosteroids in treating psoriasis?
Which of the following statements best describes the use and action of topical corticosteroids in treating psoriasis?
What is the primary mechanism by which isoniazid works to combat tuberculosis?
What is the primary mechanism by which isoniazid works to combat tuberculosis?
A patient is on long-term steroid therapy. Which of the following adverse effects is MOST likely to develop?
A patient is on long-term steroid therapy. Which of the following adverse effects is MOST likely to develop?
A patient taking methotrexate for severe psoriasis is also prescribed an antiviral medication. Which of the following best describes the differing mechanism of action between methotrexate and the likely antiviral treatment?
A patient taking methotrexate for severe psoriasis is also prescribed an antiviral medication. Which of the following best describes the differing mechanism of action between methotrexate and the likely antiviral treatment?
A patient develops a widespread rash with mucosal involvement after starting a new medication. This is quickly identified as Stevens-Johnson Syndrome, and treatment is initiated. Which aspect of care is prioritized immediately after stopping the offending agent?
A patient develops a widespread rash with mucosal involvement after starting a new medication. This is quickly identified as Stevens-Johnson Syndrome, and treatment is initiated. Which aspect of care is prioritized immediately after stopping the offending agent?
A patient experiences a recurrence of vaginal candidiasis despite using topical azoles. The physician considers transitioning to oral fluconazole. Which of the following best describes the difference in the mechanism of action between the two treatments?
A patient experiences a recurrence of vaginal candidiasis despite using topical azoles. The physician considers transitioning to oral fluconazole. Which of the following best describes the difference in the mechanism of action between the two treatments?
In treating a common wart, both salicylic acid and cryotherapy are used. Although different, they share the goal of wart removal. How do their methods of action differ?
In treating a common wart, both salicylic acid and cryotherapy are used. Although different, they share the goal of wart removal. How do their methods of action differ?
A generic drug is being compared to the brand-name equivalent. According to FDA requirements, which is the acceptable range for bioequivalence?
A generic drug is being compared to the brand-name equivalent. According to FDA requirements, which is the acceptable range for bioequivalence?
A patient's therapeutic drug level of Warfarin is found to be subtherapeutic during a routine check-up. Considering the medication's metabolism by CYP2C9, which of the following factors would MOST likely contribute to this finding?
A patient's therapeutic drug level of Warfarin is found to be subtherapeutic during a routine check-up. Considering the medication's metabolism by CYP2C9, which of the following factors would MOST likely contribute to this finding?
A patient with a history of asthma is experiencing frequent nighttime awakenings due to symptoms, despite using an inhaled corticosteroid daily. Which of the following alterations to their maintenance therapy would BEST address these symptoms?
A patient with a history of asthma is experiencing frequent nighttime awakenings due to symptoms, despite using an inhaled corticosteroid daily. Which of the following alterations to their maintenance therapy would BEST address these symptoms?
A patient with COPD presents with exacerbation of symptoms, including increased dyspnea and wheezing. Which of the following is the MOST appropriate initial bronchodilator therapy to manage this acute worsening?
A patient with COPD presents with exacerbation of symptoms, including increased dyspnea and wheezing. Which of the following is the MOST appropriate initial bronchodilator therapy to manage this acute worsening?
An elderly patient with multiple comorbidities is being treated for onychomycosis with oral terbinafine. Which factor warrants MOST careful monitoring to reduce the risk of adverse drug events?
An elderly patient with multiple comorbidities is being treated for onychomycosis with oral terbinafine. Which factor warrants MOST careful monitoring to reduce the risk of adverse drug events?
A patient with a known genetic polymorphism affecting drug metabolism is prescribed phenytoin. Given phenytoin's known saturation kinetics, what is the MOST important implication for monitoring and adjusting their dose?
A patient with a known genetic polymorphism affecting drug metabolism is prescribed phenytoin. Given phenytoin's known saturation kinetics, what is the MOST important implication for monitoring and adjusting their dose?
During an asthma exacerbation, a patient's symptoms are not fully resolving with albuterol. Considering the pathophysiology of asthma, which additional medication, focusing on the underlying cause, should be considered next?
During an asthma exacerbation, a patient's symptoms are not fully resolving with albuterol. Considering the pathophysiology of asthma, which additional medication, focusing on the underlying cause, should be considered next?
A patient is diagnosed with COPD and prescribed tiotropium. Which of the following best describes the physiological mechanism by which tiotropium improves respiratory function?
A patient is diagnosed with COPD and prescribed tiotropium. Which of the following best describes the physiological mechanism by which tiotropium improves respiratory function?
Which of the following statements correctly identifies a pharmacological difference between efinaconazole and terbinafine in the treatment of onychomycosis?
Which of the following statements correctly identifies a pharmacological difference between efinaconazole and terbinafine in the treatment of onychomycosis?
What factor contributes to the reduced oral bioavailability of propranolol?
What factor contributes to the reduced oral bioavailability of propranolol?
Which statement correctly describes a clinical relevance of CYP2D6 in drug metabolism?
Which statement correctly describes a clinical relevance of CYP2D6 in drug metabolism?
Which type of conjunctivitis is characterized by purulent discharge that requires antibiotics for treatment?
Which type of conjunctivitis is characterized by purulent discharge that requires antibiotics for treatment?
What is the primary mechanism by which fluoroquinolones cause tendon rupture?
What is the primary mechanism by which fluoroquinolones cause tendon rupture?
What is the duration of treatment with isoniazid for latent tuberculosis infection?
What is the duration of treatment with isoniazid for latent tuberculosis infection?
Which steroid-related adverse effect can significantly impact the health of long-term users?
Which steroid-related adverse effect can significantly impact the health of long-term users?
Which drug in the RIPE regimen inhibits mycolic acid synthesis?
Which drug in the RIPE regimen inhibits mycolic acid synthesis?
What is a common characteristic of both allergic and viral conjunctivitis?
What is a common characteristic of both allergic and viral conjunctivitis?
Flashcards
Acyclovir
Acyclovir
An antiviral medication used to treat herpes zoster (shingles), it inhibits viral DNA polymerase, preventing the virus from replicating.
Stevens-Johnson Syndrome (SJS)
Stevens-Johnson Syndrome (SJS)
A severe drug reaction that causes widespread rash, blisters, and mucosal involvement.
Candidiasis
Candidiasis
A fungal infection that can affect the mouth (oral thrush) or vagina.
Generic Drugs
Generic Drugs
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Bioavailability
Bioavailability
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What is Onychomycosis?
What is Onychomycosis?
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How to treat Onychomycosis effectively?
How to treat Onychomycosis effectively?
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What is Therapeutic Drug Monitoring (TDM)?
What is Therapeutic Drug Monitoring (TDM)?
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Factors influencing drug metabolism?
Factors influencing drug metabolism?
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What's the pathophysiology of Asthma?
What's the pathophysiology of Asthma?
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How do SABAs work in Asthma?
How do SABAs work in Asthma?
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What's the role of ICS in Asthma?
What's the role of ICS in Asthma?
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What's the underlying cause of COPD?
What's the underlying cause of COPD?
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CYP450 Enzyme System
CYP450 Enzyme System
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Steroids
Steroids
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Conjunctivitis
Conjunctivitis
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Fluoroquinolone-Associated Tendon Rupture
Fluoroquinolone-Associated Tendon Rupture
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Active Tuberculosis (TB)
Active Tuberculosis (TB)
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Latent Tuberculosis (TB)
Latent Tuberculosis (TB)
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Psoriasis Treatment
Psoriasis Treatment
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Herpes Zoster (Shingles)
Herpes Zoster (Shingles)
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Psoriasis
Psoriasis
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How is Onychomycosis treated?
How is Onychomycosis treated?
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What factors affect drug metabolism?
What factors affect drug metabolism?
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Describe the pathophysiology of Asthma.
Describe the pathophysiology of Asthma.
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How does albuterol help with asthma?
How does albuterol help with asthma?
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What is the role of inhaled corticosteroids in asthma?
What is the role of inhaled corticosteroids in asthma?
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Explain the underlying cause of COPD.
Explain the underlying cause of COPD.
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Bioavailability: What does it measure?
Bioavailability: What does it measure?
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What is the CYP450 Enzyme System?
What is the CYP450 Enzyme System?
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What are steroids used for?
What are steroids used for?
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What is conjunctivitis?
What is conjunctivitis?
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What is fluoroquinolone-associated tendon rupture?
What is fluoroquinolone-associated tendon rupture?
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What is active tuberculosis?
What is active tuberculosis?
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What is latent tuberculosis?
What is latent tuberculosis?
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How is psoriasis treated?
How is psoriasis treated?
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Onychomycosis
Onychomycosis
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Therapeutic Drug Monitoring (TDM)
Therapeutic Drug Monitoring (TDM)
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Asthma
Asthma
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Chronic Obstructive Pulmonary Disease (COPD)
Chronic Obstructive Pulmonary Disease (COPD)
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How do SABAs work?
How do SABAs work?
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How do ICS work?
How do ICS work?
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What is Asthma?
What is Asthma?
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What is Chronic Obstructive Pulmonary Disease (COPD)?
What is Chronic Obstructive Pulmonary Disease (COPD)?
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How do Short-Acting Beta Agonists (SABAs) work in Asthma?
How do Short-Acting Beta Agonists (SABAs) work in Asthma?
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How do Inhaled Corticosteroids (ICS) work in Asthma?
How do Inhaled Corticosteroids (ICS) work in Asthma?
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How is Shingles Treated?
How is Shingles Treated?
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What Defines Generic Drug Equivalence?
What Defines Generic Drug Equivalence?
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How is Candidiasis Treated?
How is Candidiasis Treated?
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What is Stevens-Johnson Syndrome (SJS)?
What is Stevens-Johnson Syndrome (SJS)?
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How is Severe Psoriasis Treated?
How is Severe Psoriasis Treated?
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Study Notes
Toenail Fungus (Onychomycosis)
- Cause: Fungal infection (often dermatophytes, yeast, or molds).
- Treatment:
- Topical: Efinaconazole (inhibits ergosterol synthesis).
- Topical: Ciclopirox (disrupts fungal cell membranes).
- Oral: Terbinafine (inhibits squalene epoxidase).
- Oral: Itraconazole (inhibits cytochrome P450 enzymes).
- Key Points: Oral antifungals are more effective; treatment is lengthy due to slow nail growth.
Therapeutic Levels and Drug Metabolism
- Therapeutic Drug Monitoring (TDM): Measures drug levels to ensure efficacy and avoid toxicity.
- Factors Influencing Metabolism:
- Liver function (enzymatic activity).
- Age, genetics, and comorbid conditions.
- Drug-drug interactions.
- Examples:
- Warfarin (CYP2C9 metabolism; narrow therapeutic index).
- Phenytoin (nonlinear metabolism; saturation kinetics).
- Clinical Application: Regular monitoring for drugs with narrow therapeutic indices.
Asthma
- Pathophysiology: Chronic inflammatory disorder causing airway hyperresponsiveness, mucosal edema, and bronchoconstriction.
- Treatment:
- Rescue Therapy: Short-acting beta agonists (SABAs) like albuterol (stimulates beta-2 adrenergic receptors, causing bronchodilation).
- Maintenance Therapy:
- Inhaled corticosteroids (ICS) like fluticasone (reduces airway inflammation).
- Long-acting beta agonists (LABAs) like salmeterol (prolonged beta-2 adrenergic receptor stimulation).
- Leukotriene receptor antagonists like montelukast (blocks leukotriene receptors, reducing inflammation and bronchoconstriction).
Chronic Obstructive Pulmonary Disease (COPD)
- Pathophysiology: Irreversible airflow limitation due to chronic bronchitis and/or emphysema.
- Treatment:
- Bronchodilators:
- Long-acting beta agonists (LABAs), formoterol (beta-2 adrenergic receptor agonist).
- Long-acting muscarinic antagonists (LAMAs), tiotropium (blocks muscarinic receptors, reducing bronchoconstriction).
- Inhaled corticosteroids (ICS) for severe cases or frequent exacerbations.
- Supplemental oxygen in advanced stages.
- Bronchodilators:
Bioavailability
- Definition: Proportion of a drug entering systemic circulation after oral administration.
- Influences:
- Absorption in the gastrointestinal tract.
- First-pass metabolism in the liver.
- Formulation and solubility of the drug.
- Examples:
- Propranolol: Experiences significant first-pass metabolism, reducing oral bioavailability.
- Levodopa: Often given with carbidopa to increase bioavailability.
CYP450 Enzyme System
- Role: Major enzyme family in drug metabolism.
- Why it Happens:
- Genetic polymorphisms affect enzyme activity.
- Drug interactions can inhibit or induce CYP450 enzymes, altering drug levels.
- Clinical Relevance:
- CYP3A4: Metabolizes over 50% of drugs (e.g., statins, benzodiazepines).
- CYP2D6: Variability affects codeine metabolism to morphine.
Steroids
- Uses: Anti-inflammatory and immunosuppressive (e.g., asthma, autoimmune disorders).
- Common Drugs: Prednisone, Dexamethasone.
- Mechanism of Action: Binds to glucocorticoid receptors, modulating gene expression to suppress inflammation.
- Adverse Effects: Weight gain, osteoporosis, hyperglycemia, adrenal suppression.
Conjunctivitis
- Types:
- Bacterial: Purulent discharge; treated with antibiotics (e.g., erythromycin ointment).
- Viral: Watery discharge; treated symptomatically.
- Allergic: Itchy, watery eyes; treated with antihistamines or mast cell stabilizers.
Fluoroquinolone-Associated Tendon Rupture
- Mechanism: Drug disrupts collagen synthesis.
- Examples: Ciprofloxacin, Levofloxacin.
- Risk Factors: Age > 60, corticosteroid use, kidney disease.
- Clinical Note: Avoid in patients with a history of tendon disorders.
Tuberculosis (TB)
- Active TB: Symptomatic, contagious.
- Treatment: RIPE regimen (Rifampin, Isoniazid, Pyrazinamide, Ethambutol).
- Latent TB: Asymptomatic, non-contagious.
- Treatment: Isoniazid or Rifampin for a defined period.
Psoriasis Treatment
- Mild to Moderate: Topical corticosteroids, vitamin D analogs, or phototherapy.
- Severe: Systemic agents (e.g., methotrexate or biologics).
Herpes Zoster (Shingles)
- Prodrome: Pain, tingling, or burning in the affected dermatome before rash onset.
- Treatment: Antivirals (e.g., acyclovir, valacyclovir) and pain management, including analgesics and sometimes gabapentin.
First-Line Treatment for Common Wart
- Agents: Salicylic acid, cryotherapy to cause tissue necrosis.
- Key Points: Multiple treatments may be needed.
Stevens-Johnson Syndrome (SJS)
- Cause: Severe drug reaction (e.g., sulfonamides, anticonvulsants).
- Symptoms: Widespread rash, blisters, mucosal involvement.
- Management: Stop offending agent, supportive care in intensive care unit or burn unit.
Candidiasis Treatment
- Oral Thrush: Nystatin suspension or fluconazole.
- Vaginal Candidiasis: Topical azoles (e.g., clotrimazole) or oral fluconazole.
Generic Drugs and Standards
- Concern: Generic drugs may differ slightly in inactive ingredients or bioavailability.
- Standards: Must meet FDA requirements for bioequivalence (80-125% of the brand-name drug).
- Key Note: Always monitor patient-specific factors (e.g., age, liver/kidney function) for individualized treatment. Educate patients about adherence and recognizing adverse effects.
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