Medical Quiz on Malignancies and Carcinomas

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Questions and Answers

Which of the following is LEAST likely to be associated with gastrointestinal tract (GIT) malignancies?

  • Epstein-Barr virus infection
  • Helicobacter pylori infection
  • Familial adenomatous polyposis
  • Entamoeba histolytica infection (correct)

A patient with viral hepatitis is tested. Which of the following viruses is LEAST likely to have been transmitted through parenteral routes?

  • Hepatitis B virus
  • Hepatitis E virus (correct)
  • Hepatitis C virus
  • Hepatitis G virus

The initial stages of atherosclerosis are primarily mediated by which component of the vascular wall?

  • Endothelial cells (correct)
  • Tunica adventitia
  • Smooth muscle cells
  • Tunica media

Which type of renal stone is the MOST frequently observed?

<p>Calcium oxalate (A)</p> Signup and view all the answers

The highest risk of developing endometrial carcinoma is associated with which condition?

<p>Endometrial hyperplasia with atypia (A)</p> Signup and view all the answers

The classic triad of Graves' disease includes all of the following EXCEPT:

<p>Hyperparathyroidism (C)</p> Signup and view all the answers

Which of the following is NOT a characteristic feature of Myasthenia Gravis?

<p>An example of type III hypersensitivity reaction (C)</p> Signup and view all the answers

Which of the following is LEAST likely to be classified as a sex cord-stromal tumor of the ovary?

<p>Dysgerminoma (C)</p> Signup and view all the answers

A 40-year-old male presents with a painless enlarged left testis, elevated LDH, and normal AFP levels. Which of the following is the LEAST likely differential diagnosis?

<p>Yolk sac tumor (D)</p> Signup and view all the answers

Which of the following is a typical microscopic feature of papillary thyroid carcinoma?

<p>Psammoma bodies and nuclear grooves (D)</p> Signup and view all the answers

In the context of a 45-year-old woman with jaundice, dark urine, pale stools, and right upper quadrant pain, which of these investigative findings MOST strongly suggests an obstructive etiology of her symptoms?

<p>Radio opaque shadows in the right upper quadrant seen on ultrasound (B)</p> Signup and view all the answers

Which of the following BEST characterizes the typical CSF findings in pyogenic meningitis?

<p>Decreased glucose, increased protein, neutrophilic pleocytosis (D)</p> Signup and view all the answers

Which of the following is the MOST specific morphological change seen in the brain of an individual with Alzheimer's disease?

<p>Neurofibrillary tangles and senile plaques (B)</p> Signup and view all the answers

Which of the following is NOT a recognized complication of asbestosis?

<p>Pulmonary tuberculosis (D)</p> Signup and view all the answers

Which of the following is the most accurate description of the gross appearance of an osteochondroma?

<p>A bony growth capped with cartilage, typically arising from the metaphysis of a long bone. (D)</p> Signup and view all the answers

Which of the following is the LEAST likely site for the development of atherosclerosis?

<p>Pulmonary arteries (C)</p> Signup and view all the answers

A patient presents with signs of prostatic enlargement. Microscopically, the gland shows features of benign prostatic hyperplasia. Which of the following would be MOST likely found?

<p>Increased number of acini and stroma (B)</p> Signup and view all the answers

Which of the following best characterizes the microscopic features of a Schwannoma?

<p>A mixture of spindle-shaped cells with interlacing fascicles, displaying nuclear palisading. (C)</p> Signup and view all the answers

Which of the following best describes the gross appearance of leukoplakia in the oral cavity?

<p>A raised, white plaque that cannot be scraped off. (D)</p> Signup and view all the answers

A 60-year-old man experiences severe precordial chest pain radiating to the left arm. ECG shows ST segment elevation and T wave inversion. What is the most likely immediate complication?

<p>Ventricular fibrillation. (C)</p> Signup and view all the answers

Which of the following is NOT typically associated with the pathogenesis of benign prostatic hyperplasia?

<p>Increased estrogen signaling. (D)</p> Signup and view all the answers

If a patient develops a gradual loss of weight, abdominal pain, anorexia and hematemesis, with a firm lymph node in the supraclavicular region, and a nodule at the periumbilical region, what is the most probable diagnosis?

<p>Metastatic gastric adenocarcinoma. (D)</p> Signup and view all the answers

Which of the following is NOT typically associated with the pathophysiology of the disease described in the case of the 45-year-old male with chest pain?

<p>Increased parasympathetic tone (B)</p> Signup and view all the answers

What are Verocay bodies, as discussed in pathology?

<p>Areas of palisading nuclei within cellular schwannoma. (A)</p> Signup and view all the answers

Which of the following best describes the initial microscopic changes seen in emphysema?

<p>Destruction of alveolar walls and enlarged air spaces (B)</p> Signup and view all the answers

During the evolution of lobar pneumonia, which stage is characterized by a consolidation of the lung due to outpouring of fibrinous exudate into the alveoli?

<p>Red Hepatization. (C)</p> Signup and view all the answers

A patient presents with proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Which of the following is least likely to be a cause of these symptoms?

<p>Ureteropelvic junction obstruction (C)</p> Signup and view all the answers

Which of the following is a characteristic feature that best distinguishes Ulcerative Colitis from Crohn's Disease?

<p>Continuous, superficial colonic inflammation (A)</p> Signup and view all the answers

Which of the following is least likely to be associated with the etiology of Alcoholic Liver Disease?

<p>Direct viral inflammatory damage (C)</p> Signup and view all the answers

Which of the following is the most specific laboratory marker for diagnosing an acute myocardial infarction?

<p>Troponin I or T (D)</p> Signup and view all the answers

Which of the following is NOT typically considered a risk factor for the development of gallstones?

<p>High fiber diet (C)</p> Signup and view all the answers

Which of the following is most suggestive of a hydatidiform mole on gross examination?

<p>Grape-like clusters of translucent vesicles (C)</p> Signup and view all the answers

In a renal biopsy showing glomerular hypercellularity with neutrophils in an 8-year-old boy with puffiness of face, which of the following is NOT a likely finding on immunofluorescence?

<p>Linear deposits of IgG along the glomerular basement membrane (D)</p> Signup and view all the answers

Which serological marker is the FIRST to appear in acute hepatitis B infection?

<p>HBsAg (A)</p> Signup and view all the answers

In the early phases of acute myocardial infarction (within 14 days), which microscopic change is NOT typically observed?

<p>Fibroblast proliferation (D)</p> Signup and view all the answers

The pathogenesis of cervical carcinoma is most closely associated with which of the following viral factors?

<p>Integration of viral DNA into host genome (A)</p> Signup and view all the answers

Which subtype of emphysema is most strongly linked to alpha-1 antitrypsin deficiency?

<p>Panacinar emphysema (C)</p> Signup and view all the answers

Hereditary non-polyposis colorectal cancer (HNPCC), also known as Lynch syndrome, is primarily associated with defects in which type of genes?

<p>Mismatch repair genes (D)</p> Signup and view all the answers

Which of the following is a characteristic of a complete mole compared to a partial mole?

<p>Diffuse trophoblastic hyperplasia (A)</p> Signup and view all the answers

In the context of a bone tumor in the metaphyseal area of the tibia, what is a common microscopic feature expected OTHER THAN new bone formation?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is NOT typically associated with the presentation of an elderly male patient having bleeding per rectum, altered bowel habits, loss of appetite, loss of weight, and lower quadrant abdominal discomfort?

<p>Elevated white blood cell count (D)</p> Signup and view all the answers

Which of the following is the LEAST accurate description of the gross morphology of an osteoclastoma?

<p>Often shows periosteal reaction (D)</p> Signup and view all the answers

Regarding the pathogenesis of dissecting aneurysms, which of the following processes is the LEAST likely to be involved?

<p>Calcification of the vessel wall (D)</p> Signup and view all the answers

Which of the following is LEAST associated with the typical gross features of alcoholic cirrhosis of the liver?

<p>Marked enlargement of the liver (C)</p> Signup and view all the answers

Which of the following cerebrospinal fluid (CSF) findings is LEAST likely to be observed in a patient with pyogenic meningitis?

<p>Predominance of lymphocytes (C)</p> Signup and view all the answers

Which characteristic is LEAST likely to be associated with a seminoma of the testis?

<p>Areas of hemorrhage and necrosis (A)</p> Signup and view all the answers

Which of the following is NOT typically considered a complication of a myocardial infarction?

<p>Pulmonary embolism (C)</p> Signup and view all the answers

Which of the following is LEAST likely to be associated with the morphology of a renal cell carcinoma?

<p>Predominantly located in the renal pelvis (B)</p> Signup and view all the answers

Flashcards

Pneumoconiosis

A disease characterized by the formation of fibrous nodules in the lungs, caused by the inhalation of various types of dust.

Asbestosis

A form of pneumoconiosis caused by the inhalation of asbestos fibers, leading to fibrosis and scarring of the lungs, increasing the risk of lung cancer and mesothelioma.

Cor Pulmonale

A type of lung disease caused by an increase in pressure within the pulmonary arteries, making the right ventricle work harder, leading to potential heart failure.

Linitis Plastica

A type of gastric cancer characterized by a thickened, rigid, and leathery stomach wall, appearing like a 'linings' of the stomach.

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Retinoblastoma

A rare type of eye cancer that typically appears in children, arising from the cells of the retina.

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Calcium Oxalate Renal Stone

The most common type of renal calculus, usually composed of calcium oxalate, a complex compound of calcium and oxalate.

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Hashimoto's Thyroiditis

An inflammatory disease of the thyroid gland that results in hypothyroidism, characterized by the presence of lymphocytic infiltration and fibrosis.

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Gout

A painful inflammatory condition caused by the formation of uric acid crystals in the joints, often affecting the big toe, leading to inflammation and swelling.

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Emphysema

A condition characterized by abnormal enlargement of air spaces in the lungs, leading to destruction of alveolar walls and loss of elastic recoil. This results in difficulty breathing, wheezing, and shortness of breath.

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Basal Cell Carcinoma

A type of cancer that originates in the basal layer of the epidermis, characterized by slow growth and pearly, translucent nodules.

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Pleomorphic Adenoma

A benign tumor of salivary glands, often found in the parotid gland, composed of both epithelial and connective tissue components.

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Inflammatory Bowel Disease (IBD)

An inflammatory condition of the bowel that can affect any part of the digestive tract, characterized by inflammation and ulcers. There are two main types: Crohn's disease and ulcerative colitis.

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Ewing's Sarcoma

A malignant tumor of bone, most commonly affecting children and adolescents, characterized by small, round, blue cells.

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Barrett's Esophagus

A condition in which the lining of the esophagus changes from squamous epithelium to columnar epithelium, similar to the lining of the stomach, often associated with acid reflux.

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Endometrial Hyperplasia

A condition characterized by an abnormal overgrowth of cells in the lining of the uterus, leading to heavy menstrual bleeding and increased risk of endometrial cancer.

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Endometriosis

A condition in which tissue similar to the lining of the uterus grows outside the uterus, commonly affecting the ovaries, fallopian tubes, and pelvic cavity.

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Cervical Intraepithelial Neoplasia (CIN)

A precancerous condition of the cervix characterized by abnormal cell growth in the epithelial lining. CIN is graded from CIN 1 to CIN 3, with increasing severity and risk of progression to invasive cervical cancer.

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Schwannoma

A benign tumor arising from Schwann cells, which are the cells that produce the myelin sheath around nerve fibers. Schwannomas are typically slow-growing and often asymptomatic.

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Leukoplakia of oral Cavity

A white patch or lesion on the mucous membrane of the oral cavity. It can be caused by various factors, including smoking, alcohol consumption, and chronic irritation.

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Benign Prostatic Hyperplasia

A condition characterized by an increase in the size of the prostate gland, often leading to urinary symptoms such as difficulty starting urination, frequent urination, and weak urine stream.

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Gastrointestinal Stromal Tumour (GIST)

A type of cancer that originates in the smooth muscle cells of the gastrointestinal tract. GISTs can occur in any part of the GI tract, but are most common in the stomach and small intestine.

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Osteomyelitis

An inflammatory condition affecting the bone marrow and the surrounding bone tissue, often caused by bacterial infections. Osteomyelitis can lead to bone destruction and abscess formation.

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Dense Deposit Disease (Type 11 MPGN)

A type of kidney disease characterized by the deposition of dense immune complexes within the glomerular basement membrane. It is a rare but severe form of glomerulonephritis.

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Phyllodes Tumour

A type of breast tumor that is typically slow-growing and benign. Phyllodes tumors are characterized by their leaf-like appearance under the microscope.

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Krukenberg Tumor

A type of metastatic cancer found in the ovaries. It's characterized by cells that resemble signet ring cells, often originating from primary cancers in the stomach or colon.

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Papillary Thyroid Carcinoma

A type of cancer that arises from the glands of the thyroid, characterized by cells that form small follicles and are usually encapsulated.

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Ulcerative Colitis

A condition where the lining of the colon becomes inflamed and ulcerated, often resulting in bloody diarrhea, abdominal pain, and weight loss.

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Alcoholic Liver Disease

A chronic liver disease caused by excessive alcohol consumption, characterized by inflammation, fibrosis, and cirrhosis.

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Dilated Cardiomyopathy

A condition characterized by a dilated and weakened heart muscle, resulting in impaired pumping function, leading to heart failure.

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Renal Stones

Solid, hard masses that form within the kidneys, often made up of calcium salts. They can cause pain, obstruction of urine flow, and blood in the urine.

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Prostatic Enlargement

An increase in the size of the prostate gland, most commonly caused by benign prostatic hyperplasia. It can cause problems with urination, like difficulty starting and stopping the flow.

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Cardiac Vegetation

Clusters of bacteria, fungus, or other infectious agents that form on heart valves, causing inflammation and heart damage. These can cause fever, fatigue, even stroke, and are very dangerous.

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Giant Cell Tumor (Osteoclastoma)

A benign tumor of the bone, typically found in the ends of long bones, characterized by the presence of numerous giant cells and a stroma of fibrous connective tissue.

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X-ray appearance of Giant Cell Tumor

A type of bone tumor that often occurs in the ends of long bones, especially around the knee.

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Microscopic picture of Giant Cell Tumor

The microscopic appearance of Giant Cell Tumor reveals numerous multinucleated giant cells, surrounded by a fibrous stroma and numerous small, spindle-shaped cells.

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Bacterial Endocarditis

A rare and serious infection of the inner lining of the heart, often caused by bacteria, leading to damage to heart valves, potential heart failure, and even stroke.

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Complications of Bacterial Endocarditis

Complications of Bacterial Endocarditis can include heart valve damage, heart failure, stroke, emboli, and even death.

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Classification of Ovarian Tumors

Tumors arising from the ovaries can be classified into epithelial, germ cell, sex cord-stromal, and metastatic tumors.

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Staging of Hodgkin's Disease

A staging system used to categorize Hodgkin's disease, based on the extent of the disease, the number of lymph node regions involved, and the presence of extra-nodal involvement.

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What is acute glomerulonephritis?

An acute condition characterized by glomerular hypercellularity with neutrophils, often presenting with puffiness of face and decreased urine output. It is typically accompanied by hematuria and mild proteinuria.

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What is Crohn's disease?

A chronic inflammatory bowel disease characterized by patchy areas of inflammation in the gastrointestinal tract, primarily affecting the ileum and colon, but also the small bowel. It can cause abdominal pain, diarrhea, weight loss, and fatigue.

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What is ulcerative colitis?

An inflammatory bowel disease that primarily affects the large intestine, specifically the colon and rectum. It is characterized by inflammation causing ulcerations and inflammation, with symptoms including bloody diarrhea, abdominal pain, and weight loss.

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What is cervical carcinoma?

A type of cancer that arises from the epithelial cells of the cervix, often associated with infection by human papillomavirus (HPV). It can spread to other parts of the body.

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What is emphysema?

A chronic lung disease characterized by abnormal enlargement and destruction of the airways, often caused by smoking or other irritants. It leads to airflow obstruction and shortness of breath.

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What is seminoma testis?

A tumor of the germ cells in the testes, characterized by large cells with clear cytoplasm. It is typically slow-growing and often curable with early detection and treatment.

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What is Barrett's esophagus?

A condition characterized by the appearance of columnar epithelial cells in the esophagus, replacing the normal squamous epithelium. It is often associated with gastroesophageal reflux disease (GERD).

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What is basal cell carcinoma?

A malignant tumor of the basal layer of the epidermis, characterized by slow, localized growth, often appearing as a pearly, waxy nodule or a flat, scar-like lesion.

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Study Notes

Multiple Choice Questions

  • GIT malignancies: Not associated with amoebiasis.
  • Hepatitis Transmission: Hepatitis B virus is not transmitted parenterally.
  • Atherosclerosis: Atherosclerosis initiation is mediated by endothelium.
  • Renal Stones: The most common type of renal stone is calcium oxalate.
  • Endometrial Carcinoma Risk: Endometrial hyperplasia with atypia has the highest risk of endometrial carcinoma.
  • Graves Disease Triad: Hyperparathyroidism is not part of the triad of Graves' disease.
  • Myasthenia Gravis: Patients with myasthenia gravis typically have anti-AChR antibodies and thymic hyperplasia.
  • Ovarian Tumors: Dysgerminoma and thecoma are not considered sex cord tumors.
  • HPV Infection: Koilocytosis is a characteristic feature of HPV infection in Pap smears.
  • Bone Tumors: Chondrosarcoma is a bone tumor with a specific histology of small round cells.

Long Answer Questions

  • Asbestosis: Pneumoconiosis classification; pathology and complications of asbestosis.
  • Bone Tumors: Classification of bone tumors and details of osteogenic sarcoma.
  • Pastures Syndrome: Good Pastures syndrome details
  • Pulmonary Hypertension: Cor Pulmonale details
  • Linitis plastica: Details on Linitis plastica
  • Retinoblastoma: Details on Retinoblastoma
  • Lung Abscess: Details on Lung Abscess
  • Hashimoto's Thyroiditis: Details on Hashimoto's Thyroiditis
  • Gout: Details on Gout
  • Meckel's Diverticulum: Details on Meckel's Diverticulum
  • Psammoma Bodies: Details on Psammoma bodies
  • Amyloidosis: Details on Amyloidosis
  • Wilson's Disease: Details on Wilson's disease
  • Schwannoma Microscopy: Details on Schwannoma microscopy
  • Schiller Duval Body: Details on Schiller Duval body

Additional Exam Questions

  • Cirrhosis: Definition, classification, and morphological features of alcoholic liver disease.
  • Pleomorphic Adenoma: Short note on pleomorphic adenoma.
  • Malignant Melanoma: Short note on malignant melanoma.
  • Bronchiectasis: Pathogenesis and complications of bronchiectasis.
  • Polycystic Kidney Disease (Adult): Short note on adult polycystic kidney disease.
  • Papillary Carcinoma Thyroid: Brief description of papillary carcinoma thyroid.
  • Aneurysm: Define aneurysm and mention types.
  • Hodgkin Lymphoma: Classification of Hodgkin lymphoma.
  • Fibroadenoma: Description of fibroadenoma
  • Malignant Hypertension: Kidney changes in malignant hypertension.
  • Schwannoma: Microscopy of schwannoma.
  • Bone Tumors: Classification of bone tumors, etiology and pathogenesis of osteosarcoma, and description of the clinical, microscopic, and radiologic features of osteosarcoma.
  • Acute Rheumatic Fever Clinical features, etiopathogenesis, cardiac changes, outcomes, and complications of acute rheumatic fever.
  • Chronic Pancreatitis: Brief note on chronic pancreatitis
  • Cervical Carcinoma: Etiopathogenesis of cervical carcinoma
  • Seminoma: Morphology, pathogenesis, of seminoma
  • Renal Cell Carcinoma: Morphology of renal cell carcinoma.
  • Type II Diabetes Mellitus: Pathogenesis of type II diabetes mellitus
  • Leiomyoma: Leiomyoma - sites, gross, microscopy
  • Acute Respiratory Distress Syndrome: Pathogenesis of acute respiratory distress syndrome
  • Colonic Carcinoma: Etiopathogenesis of colonic carcinoma
  • Cirrhosis Complications: Complications of cirrhosis
  • Precancerous Lesions (Penis): List three precancerous lesions of penis
  • Chronic Pyelonephritis: Morphology of chronic pyelonephritis
  • Gallstones: Types of gall stones
  • Endometrial Carcinoma Risk Factors: Risk factors for endometrial carcinoma
  • Bronchiectasis Complications: Pathogenesis and complications of bronchiectasis
  • Lung Abscess Complications: List complications of lung abscess
  • Warthin's Tumor: Morphology of Warthin's tumor
  • Berry Aneurysm: Details on berry aneurysm
  • Lobar Pneumonia: Stages of lobar pneumonia

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