Lec 4
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Questions and Answers

Which pathway of arachidonic acid metabolism is targeted by naproxen?

  • 12-lipoxygenase pathway
  • Cyclooxygenase pathway (correct)
  • Epoxide hydrolase pathway
  • 15-lipoxygenase pathway
  • What is the main effect of naproxen on prostaglandin generation in the context of inflammation?

  • Complete cessation of prostaglandin production
  • Increased prostaglandin synthesis
  • Unchanged prostaglandin levels
  • Reduced prostaglandin generation (correct)
  • Which molecule promotes vasodilation at sites of inflammation?

  • Prostaglandins (correct)
  • Interferons
  • Leukotrienes
  • Thromboxanes
  • What is the primary function of chemokines in the inflammatory response?

    <p>Stimulation of chemotaxis</p> Signup and view all the answers

    Which cytokines are involved in driving leukocyte release from bone marrow?

    <p>Interleukin-1 (IL-1) and Tumor necrosis factor (TNF)</p> Signup and view all the answers

    What assists leukocyte emigration in the inflammatory response?

    <p>Adhesion molecules</p> Signup and view all the answers

    Which function is NOT affected by naproxen in the acute inflammatory response?

    <p>Leukocytosis</p> Signup and view all the answers

    Which enzyme is responsible for the production of prostaglandins PGI2, PGD2, and PGE2 from arachidonic acid?

    <p>Cyclooxygenase</p> Signup and view all the answers

    Which arachidonic acid metabolite mediates vasodilation and increased vascular permeability?

    <p>Prostaglandin PGI2</p> Signup and view all the answers

    Which arachidonic acid metabolite attracts activated neutrophils?

    <p>Leukotriene LTB4</p> Signup and view all the answers

    Which enzyme produces leukotrienes that mediate vasoconstriction, bronchospasm, and increased vascular permeability?

    <p>5-lipoxygenase</p> Signup and view all the answers

    Which of the following is a common symptom mediated by prostaglandin PGE2?

    <p>Pain</p> Signup and view all the answers

    Which blood plasma component is most likely to facilitate phagocytosis by neutrophils or lysis of bacteria?

    <p>Complement</p> Signup and view all the answers

    How can activation of complement occur?

    <p>Via microbial cell wall components</p> Signup and view all the answers

    Which complement component acts as a neutrophil chemoattractant?

    <p>C5a</p> Signup and view all the answers

    What is the function of complement C3b?

    <p>Opsonization</p> Signup and view all the answers

    Which blood plasma component is generated from plasminogen and helps in clot lysis?

    <p>Plasmin</p> Signup and view all the answers

    What is the primary function of kallikrein in the context of inflammation?

    <p>Bradykinin generation</p> Signup and view all the answers

    Which component is not closely associated with coagulation among the given options?

    <p>Kallikrein</p> Signup and view all the answers

    Which protein is part of the membrane attack complex involved in immunity?

    <p>C5-9</p> Signup and view all the answers

    Which vasoactive amines are named because of their important actions on blood vessels?

    <p>Histamine and serotonin</p> Signup and view all the answers

    Which substance is generated from the kinin system and promotes vascular permeability, smooth muscle contraction, and pain?

    <p>Bradykinin</p> Signup and view all the answers

    What is the major chemotactic factor for neutrophils?

    <p>Complement C5a</p> Signup and view all the answers

    Which substances mediate systemic effects like fever, metabolic wasting, and hypotension?

    <p>Interleukin-1 and tumor necrosis factor</p> Signup and view all the answers

    Which factor is produced by surface contact of Hageman factor with collagen and basement membrane?

    <p>Bradykinin</p> Signup and view all the answers

    What are the two major vasoactive amines mentioned in the text?

    <p>Serotonin and bradykinin</p> Signup and view all the answers

    What promotes smooth muscle contraction, vascular permeability, and pain?

    <p>Bradykinin</p> Signup and view all the answers

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