Podcast
Questions and Answers
Which pathway of arachidonic acid metabolism is targeted by naproxen?
Which pathway of arachidonic acid metabolism is targeted by naproxen?
- 12-lipoxygenase pathway
- Cyclooxygenase pathway (correct)
- Epoxide hydrolase pathway
- 15-lipoxygenase pathway
What is the main effect of naproxen on prostaglandin generation in the context of inflammation?
What is the main effect of naproxen on prostaglandin generation in the context of inflammation?
- Complete cessation of prostaglandin production
- Increased prostaglandin synthesis
- Unchanged prostaglandin levels
- Reduced prostaglandin generation (correct)
Which molecule promotes vasodilation at sites of inflammation?
Which molecule promotes vasodilation at sites of inflammation?
- Prostaglandins (correct)
- Interferons
- Leukotrienes
- Thromboxanes
What is the primary function of chemokines in the inflammatory response?
What is the primary function of chemokines in the inflammatory response?
Which cytokines are involved in driving leukocyte release from bone marrow?
Which cytokines are involved in driving leukocyte release from bone marrow?
What assists leukocyte emigration in the inflammatory response?
What assists leukocyte emigration in the inflammatory response?
Which function is NOT affected by naproxen in the acute inflammatory response?
Which function is NOT affected by naproxen in the acute inflammatory response?
Which enzyme is responsible for the production of prostaglandins PGI2, PGD2, and PGE2 from arachidonic acid?
Which enzyme is responsible for the production of prostaglandins PGI2, PGD2, and PGE2 from arachidonic acid?
Which arachidonic acid metabolite mediates vasodilation and increased vascular permeability?
Which arachidonic acid metabolite mediates vasodilation and increased vascular permeability?
Which arachidonic acid metabolite attracts activated neutrophils?
Which arachidonic acid metabolite attracts activated neutrophils?
Which enzyme produces leukotrienes that mediate vasoconstriction, bronchospasm, and increased vascular permeability?
Which enzyme produces leukotrienes that mediate vasoconstriction, bronchospasm, and increased vascular permeability?
Which of the following is a common symptom mediated by prostaglandin PGE2?
Which of the following is a common symptom mediated by prostaglandin PGE2?
Which blood plasma component is most likely to facilitate phagocytosis by neutrophils or lysis of bacteria?
Which blood plasma component is most likely to facilitate phagocytosis by neutrophils or lysis of bacteria?
How can activation of complement occur?
How can activation of complement occur?
Which complement component acts as a neutrophil chemoattractant?
Which complement component acts as a neutrophil chemoattractant?
What is the function of complement C3b?
What is the function of complement C3b?
Which blood plasma component is generated from plasminogen and helps in clot lysis?
Which blood plasma component is generated from plasminogen and helps in clot lysis?
What is the primary function of kallikrein in the context of inflammation?
What is the primary function of kallikrein in the context of inflammation?
Which component is not closely associated with coagulation among the given options?
Which component is not closely associated with coagulation among the given options?
Which protein is part of the membrane attack complex involved in immunity?
Which protein is part of the membrane attack complex involved in immunity?
Which vasoactive amines are named because of their important actions on blood vessels?
Which vasoactive amines are named because of their important actions on blood vessels?
Which substance is generated from the kinin system and promotes vascular permeability, smooth muscle contraction, and pain?
Which substance is generated from the kinin system and promotes vascular permeability, smooth muscle contraction, and pain?
What is the major chemotactic factor for neutrophils?
What is the major chemotactic factor for neutrophils?
Which substances mediate systemic effects like fever, metabolic wasting, and hypotension?
Which substances mediate systemic effects like fever, metabolic wasting, and hypotension?
Which factor is produced by surface contact of Hageman factor with collagen and basement membrane?
Which factor is produced by surface contact of Hageman factor with collagen and basement membrane?
What are the two major vasoactive amines mentioned in the text?
What are the two major vasoactive amines mentioned in the text?
What promotes smooth muscle contraction, vascular permeability, and pain?
What promotes smooth muscle contraction, vascular permeability, and pain?
