27 Questions
Which pathway of arachidonic acid metabolism is targeted by naproxen?
Cyclooxygenase pathway
What is the main effect of naproxen on prostaglandin generation in the context of inflammation?
Reduced prostaglandin generation
Which molecule promotes vasodilation at sites of inflammation?
Prostaglandins
What is the primary function of chemokines in the inflammatory response?
Stimulation of chemotaxis
Which cytokines are involved in driving leukocyte release from bone marrow?
Interleukin-1 (IL-1) and Tumor necrosis factor (TNF)
What assists leukocyte emigration in the inflammatory response?
Adhesion molecules
Which function is NOT affected by naproxen in the acute inflammatory response?
Leukocytosis
Which enzyme is responsible for the production of prostaglandins PGI2, PGD2, and PGE2 from arachidonic acid?
Cyclooxygenase
Which arachidonic acid metabolite mediates vasodilation and increased vascular permeability?
Prostaglandin PGI2
Which arachidonic acid metabolite attracts activated neutrophils?
Leukotriene LTB4
Which enzyme produces leukotrienes that mediate vasoconstriction, bronchospasm, and increased vascular permeability?
5-lipoxygenase
Which of the following is a common symptom mediated by prostaglandin PGE2?
Pain
Which blood plasma component is most likely to facilitate phagocytosis by neutrophils or lysis of bacteria?
Complement
How can activation of complement occur?
Via microbial cell wall components
Which complement component acts as a neutrophil chemoattractant?
C5a
What is the function of complement C3b?
Opsonization
Which blood plasma component is generated from plasminogen and helps in clot lysis?
Plasmin
What is the primary function of kallikrein in the context of inflammation?
Bradykinin generation
Which component is not closely associated with coagulation among the given options?
Kallikrein
Which protein is part of the membrane attack complex involved in immunity?
C5-9
Which vasoactive amines are named because of their important actions on blood vessels?
Histamine and serotonin
Which substance is generated from the kinin system and promotes vascular permeability, smooth muscle contraction, and pain?
Bradykinin
What is the major chemotactic factor for neutrophils?
Complement C5a
Which substances mediate systemic effects like fever, metabolic wasting, and hypotension?
Interleukin-1 and tumor necrosis factor
Which factor is produced by surface contact of Hageman factor with collagen and basement membrane?
Bradykinin
What are the two major vasoactive amines mentioned in the text?
Serotonin and bradykinin
What promotes smooth muscle contraction, vascular permeability, and pain?
Bradykinin
Test your knowledge on the mediators of inflammation focusing on mast cells and vasoactive amines like histamine and serotonin. Identify key concepts such as vascular permeability, mucous secretions, and the role of bradykinin in promoting various physiological responses.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
