24 Questions
Which theory of anesthesia initially believed that anesthetics, being lipid soluble, dissolved in the lipid bilayer and produced changes in the membrane structure sufficient to induce anesthesia?
Unitary Theory of Anesthesia
What is the likely primary site of action of general anesthetics according to the electrophysiologic effects?
Synaptic
Which ion channel is likely involved in the electrophysiological effects of anesthetics and is not highly sensitive to anesthetics as a whole?
HCN
Which ion channel is involved in synaptic effects and is inhibited by volatile anesthetics?
Ca++
Which type of effect on GABAA receptor channels is seen at supraclinical concentrations of anesthetic?
Direct gating
Which ligand-gated ion channel activation enhances higher-order brain function such as learning, memory, and attention?
Nicotinic acetylcholine receptor
Which of the following ion channels is NOT primarily involved in the electrophysiological effects of general anesthetics?
Ligand-gated ion channels
What is the primary site of action of dexmedetomidine?
Locus coeruleus (LC)
Which area plays an important role in the emergence from anesthesia?
Perifornical area (PF)
What is the role of Orexin in stabilizing the sleep-wake switch?
Stimulates the Tuberomamillary nucleus (TMN)
Which neurotransmitter directly stimulates the cerebral cortex through Ach release from the nucleus basalis of Meynert (NBM)?
Histamine
Which anesthetic is associated with an incidence of awareness with recall during general anesthesia?
Nitrous oxide
What does BIS (Bispectral Index) assess in monitoring awareness under anesthesia?
Burst suppression
At what MAC percentage does unconscious memory (implicit) get ablated by general anesthesia with Isoflurane?
$0.6$%
What range of BIS indicates a patient under general anesthesia?
$40-60$
Which component is thought to be primarily mediated at the spinal cord level?
Immobility
What is the primary source of NE to the cerebral cortex?
Locus coeruleus
According to the text, which nucleus is involved in creating a sleep-wake cycle?
Tuberomamillary nucleus
Which component is considered to be the primary site of action of dexmedetomidine?
Attenuation of autonomic response
According to the text, what is the target for anesthetic action now thought to be?
Protein
Which theory initially believed that anesthetics dissolved in the lipid bilayer and produced changes in membrane structure sufficient to induce anesthesia?
Lipid Hypothesis
Which component of general anesthesia generally impairs short-term memory while leaving long-term memory intact?
Amnesia
According to the text, which component is believed to be mediated primarily at the synapse?
Analgesia
Which components constitute general anesthesia?
Unconsciousness, amnesia, analgesia, immobility, and attenuation of autonomic response
Learn about the five components of general anesthesia, including unconsciousness, amnesia, analgesia, immobility, and attenuation of autonomic response. Explore the alterations in awareness and arousal in an unconscious state and the interaction of brain nuclei in creating the sleep-wake cycle. Dive into the induction and emergence process during anesthesia.
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