Mechanisms of Action of Antibiotics

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Questions and Answers

Which enzymes do β-lactam antibiotics inhibit to prevent the formation of crosslinks in bacteria?

  • Polymerases
  • Kinases
  • Ligases
  • Transpeptidases (correct)

What is the mechanism of action shared by cephalosporins and penicillins in targeting bacteria?

  • Inhibition of protein synthesis
  • Altering cell membrane function
  • Targeting transpeptidases (correct)
  • Inhibition of DNA synthesis

Which drug class includes vancomycin and teicoplanin as antibiotics?

  • Macrolides
  • Quinolones
  • Tetracyclines
  • Glycopeptides (correct)

What is the main target of sulfonamides in bacteria during folic acid synthesis?

<p>Dihydropteroate synthase (C)</p> Signup and view all the answers

Which mechanism do monobactams act through to combat microorganisms?

<p>Inhibition of transpeptidase (A)</p> Signup and view all the answers

What role do penicillin-binding proteins (PBPs) play in bacterial cell wall synthesis?

<p>Crosslinking peptide chains in peptidoglycan (C)</p> Signup and view all the answers

Which type of bacteria are carbapenems particularly effective against?

<p>Both Gram-positive and Gram-negative bacteria (A)</p> Signup and view all the answers

Which antibiotic specifically targets the transpeptidase involved in peptidoglycan synthesis?

<p>Aztreonam (D)</p> Signup and view all the answers

Which class of antibiotics acts on the 50S ribosomal subunit in bacteria?

<p>Macrolides (C)</p> Signup and view all the answers

Which enzyme is blocked by Quinolones to inhibit bacterial DNA synthesis?

<p>DNA gyrase (C)</p> Signup and view all the answers

What is the target of Lincomycins like clindamycin in bacteria?

<p>50S ribosomal subunit (A)</p> Signup and view all the answers

Which antibiotic class is known for blocking bacterial RNA polymerase to inhibit mRNA synthesis?

<p>Rifampin (A)</p> Signup and view all the answers

How do polymyxins like colistin disrupt bacterial cell membranes?

<p>By interacting with positively charged phospholipids (B)</p> Signup and view all the answers

Which enzyme do sulfonamides competitively inhibit in the folate synthesis pathway?

<p>Dihydrofolate reductase (D)</p> Signup and view all the answers

How does trimethoprim contribute to the inhibition of folate synthesis?

<p>By inhibiting dihydrofolate reductase (B)</p> Signup and view all the answers

What is the ultimate result of disrupting the integrity of the bacterial cell membrane by colistin?

<p>Cell death by destroying the selective barrier function (C)</p> Signup and view all the answers

Which group of antibiotics interfere with specific metabolic pathways essential for microorganisms?

<p>Metabolic inhibitors (D)</p> Signup and view all the answers

Why is resistance to antimicrobial drugs a concerning issue?

<p>It impacts the treatment of bacterial infections (A)</p> Signup and view all the answers

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