Mechanism of Toxicity Quiz
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Questions and Answers

What is the first step in the mechanism of toxicity?

  • Repair or Dysrepair
  • Cellular Dysfunction and Resultant Toxicity
  • Delivery: Site of Exposure to the Target (correct)
  • Reaction of the ultimate toxicant with the target molecule

    • Which route of exposure involves inhaling the toxicant?

  • Inhale through the respiratory tract (correct)
  • Can be exposed from the toxicant through the skin
  • Ingest the toxicant (GI Tract)
  • Absorption

    • What process increases the concentration of toxicants at the target site?

  • Reabsorption
  • Pre-systemic elimination
  • Distribution away from the target
  • Toxication (correct)

    • Which step involves the transfer of chemicals from the site of exposure to systemic circulation?

    <p>Absorption</p> Signup and view all the answers

    What is the term for unprogrammed cell death?

    <p>Necrosis</p> Signup and view all the answers

    Where does detoxification of toxicants primarily occur?

    <p>In the liver</p> Signup and view all the answers

    What is the main difference between necrosis and apoptosis?

    <p>Necrosis involves bursting of the cell and release of damaging substances, while apoptosis results in cell shrinking and release of apoptotic bodies.</p> Signup and view all the answers

    Why is the absorption of chemicals important in determining toxicity?

    <p>Absorbed chemicals can lead to systemic toxicity.</p> Signup and view all the answers

    Which route of exposure generally leads to the highest toxicity?

    <p>Injection</p> Signup and view all the answers

    What happens during necrosis in response to tissue damage?

    <p>Mitochondria release damaging substances upon bursting.</p> Signup and view all the answers

    How do apoptotic bodies get eliminated after cell death?

    <p>They are phagocytosed by immune cells like macrophages.</p> Signup and view all the answers

    Why is ethanol readily absorbed from the gastrointestinal tract but not through the skin?

    <p>Absorption rates vary based on the form of a chemical and the route of exposure.</p> Signup and view all the answers

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