Mechanism of Toxicity Quiz

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Questions and Answers

What is the first step in the mechanism of toxicity?

Repair or Dysrepair
Cellular Dysfunction and Resultant Toxicity
Delivery: Site of Exposure to the Target (correct)
Reaction of the ultimate toxicant with the target molecule

Which route of exposure involves inhaling the toxicant?

Inhale through the respiratory tract (correct)
Can be exposed from the toxicant through the skin
Ingest the toxicant (GI Tract)
Absorption

What process increases the concentration of toxicants at the target site?

Reabsorption
Pre-systemic elimination
Distribution away from the target
Toxication (correct)

Which step involves the transfer of chemicals from the site of exposure to systemic circulation?

Absorption (D) Signup and view all the answers

What is the term for unprogrammed cell death?

Necrosis (A) Signup and view all the answers

Where does detoxification of toxicants primarily occur?

In the liver (B) Signup and view all the answers

What is the main difference between necrosis and apoptosis?

Necrosis involves bursting of the cell and release of damaging substances, while apoptosis results in cell shrinking and release of apoptotic bodies. (C) Signup and view all the answers

Why is the absorption of chemicals important in determining toxicity?

Absorbed chemicals can lead to systemic toxicity. (C) Signup and view all the answers

Which route of exposure generally leads to the highest toxicity?

Injection (A) Signup and view all the answers

What happens during necrosis in response to tissue damage?

Mitochondria release damaging substances upon bursting. (D) Signup and view all the answers

How do apoptotic bodies get eliminated after cell death?

They are phagocytosed by immune cells like macrophages. (C) Signup and view all the answers

Why is ethanol readily absorbed from the gastrointestinal tract but not through the skin?

Absorption rates vary based on the form of a chemical and the route of exposure. (C) Signup and view all the answers

Flashcards

What is 'Delivery' in toxicology?

Movement of a toxicant from the exposure site to the target organ or tissue.

What exposure route involves breathing in a toxicant?

Inhalation of a toxicant through the respiratory system.