Podcast
Questions and Answers
Which repair mechanism is specifically designed to correct chemically modified bases in DNA?
Which repair mechanism is specifically designed to correct chemically modified bases in DNA?
- Mismatch Repair (MMS)
- Nucleotide Excision Repair (NER)
- Homologous Recombination (HR)
- Base Excision Repair (BER) (correct)
What type of DNA damage is primarily repaired by Nucleotide Excision Repair (NER)?
What type of DNA damage is primarily repaired by Nucleotide Excision Repair (NER)?
- Bulky lesions like Thymine-Thymine dimers (correct)
- Double-strand breaks
- Single-strand breaks
- Chemical changes in bases
Which repair mechanism is responsible for detecting and correcting errors that occur during DNA replication?
Which repair mechanism is responsible for detecting and correcting errors that occur during DNA replication?
- NHEJ
- Base Excision Repair (BER)
- Homologous Recombination (HR)
- Proof-reading (correct)
What is one of the common sources of DNA damage leading to Thymine-Thymine dimers?
What is one of the common sources of DNA damage leading to Thymine-Thymine dimers?
During DNA replication, which repair mechanism helps in joining broken DNA ends?
During DNA replication, which repair mechanism helps in joining broken DNA ends?
Which process can lead to the conversion of cytosine (C) to thymine (T) in DNA?
Which process can lead to the conversion of cytosine (C) to thymine (T) in DNA?
Which repair mechanism focuses on correcting errors after DNA has been synthesized?
Which repair mechanism focuses on correcting errors after DNA has been synthesized?
What is the first step in the repair of double-strand breaks (DSB) through homologous recombination (HR)?
What is the first step in the repair of double-strand breaks (DSB) through homologous recombination (HR)?
Which repair mechanism involves the removal of chemically modified bases to prevent point mutations after replication?
Which repair mechanism involves the removal of chemically modified bases to prevent point mutations after replication?
What is the function of DNA glycosylase in the Base Excision Repair (BER) mechanism?
What is the function of DNA glycosylase in the Base Excision Repair (BER) mechanism?
Which proteins' mutations can potentiate human cancers by affecting homologous recombination repair?
Which proteins' mutations can potentiate human cancers by affecting homologous recombination repair?
In double-strand break repair (DSB), which process involves DNA strand exchange between separate DNA molecules?
In double-strand break repair (DSB), which process involves DNA strand exchange between separate DNA molecules?
Which repair mechanism is responsible for repairing Thymine-Thymine dimers induced by U.V. light?
Which repair mechanism is responsible for repairing Thymine-Thymine dimers induced by U.V. light?
What is the main function of Xeroderma pigmentosum genes in the repair of DNA damage?
What is the main function of Xeroderma pigmentosum genes in the repair of DNA damage?
What is the final step in the repair of double-strand breaks (DSB) through homologous recombination (HR)?
What is the final step in the repair of double-strand breaks (DSB) through homologous recombination (HR)?
Individuals with Xeroderma pigmentosum have a higher predisposition to which types of cancer due to their DNA repair defects?
Individuals with Xeroderma pigmentosum have a higher predisposition to which types of cancer due to their DNA repair defects?
Which repair mechanism involves a proofreading process to correct errors in DNA replication?
Which repair mechanism involves a proofreading process to correct errors in DNA replication?
In E.coli, approximately how many bases are wrongly matched during replication?
In E.coli, approximately how many bases are wrongly matched during replication?
In homologous recombination, what is the term used for the cleavage and ligation process that resolves the Holiday Junction?
In homologous recombination, what is the term used for the cleavage and ligation process that resolves the Holiday Junction?
Which gene mutations can lead to an inherited susceptibility to breast cancer?
Which gene mutations can lead to an inherited susceptibility to breast cancer?
Which step involves the opening of the DNA duplex in the Nucleotide Excision Repair (NER) pathway?
Which step involves the opening of the DNA duplex in the Nucleotide Excision Repair (NER) pathway?
'Glycosylation' by DNA glycosylase marks the chemically modified base with what?
'Glycosylation' by DNA glycosylase marks the chemically modified base with what?
Which protein cleaves off the modified base as part of the Base Excision Repair (BER) mechanism?
Which protein cleaves off the modified base as part of the Base Excision Repair (BER) mechanism?
What is the primary reason for the low mutation rate of 1 every 100 million bases?
What is the primary reason for the low mutation rate of 1 every 100 million bases?
Which repair pathway fixes mistakes that have escaped the proofreading activity of DNA polymerase?
Which repair pathway fixes mistakes that have escaped the proofreading activity of DNA polymerase?
What is the most serious form of DNA damage discussed in the text?
What is the most serious form of DNA damage discussed in the text?
Which repair mechanism is prone to errors and is the most common form in mammalian cells?
Which repair mechanism is prone to errors and is the most common form in mammalian cells?
Which repair pathway is more accurate and only possible when homologous sequences are available?
Which repair pathway is more accurate and only possible when homologous sequences are available?
Which step follows the recognition of double strand breaks by Ku in the NHEJ repair mechanism?
Which step follows the recognition of double strand breaks by Ku in the NHEJ repair mechanism?
