30 Questions
HR repair involves the ______ of strands between separate DNA molecules.
exchange
The protein participating in homologous recombination repair is encoded by the ______ genes.
BRCA-1 or BRCA-2
The first step in HR repair is the ______ of the 5' end to leave highly recombinogenic 3' ends.
digestion
Strand invasion in HR repair is mediated by ______.
Rad51
The resolution of the Holiday Junction can lead to ______ or crossover.
gene conversion
HR repair can occur through multiple pathways, including ______ and SDSA.
DSBR
Homologous recombination repair is a mechanism that can repair ______ strand breaks.
double
The Base Excision Repair (BER) mechanism removes chemically modified ______ and prevents point mutations after replication.
bases
Thymine-Thymine ______ are formed when DNA is exposed to UV light.
dimers
The Nucleotide Excision Repair (NER) pathway is the main mechanism that repairs ______ dimers.
Thymine-Thymine
In the BER mechanism, the modified base is marked with a ______ by DNA glycosylase.
sugar
The APE1 endonuclease cleaves the ______ off in the BER mechanism.
base
Xeroderma pigmentosum is a hereditary disease associated with a predisposition to ______ due to defects in DNA repair.
cancer
In E. coli, 1 ______ every 10,000 is wrongly matched during replication, resulting in replication errors.
base
Base Excision Repair (BER) fixes ______ changes in DNA.
chemical
UV light can cause ______ formation in DNA.
Thymine-Thymine
The accumulation of ______ in the cell's DNA can lead to tumor formation and cancer.
mutations
Nucleotide Excision Repair (NER) is a mechanism that repairs ______ in DNA.
damage
Mismatch Repair (MMS) is a type of repair mechanism that corrects ______ errors in DNA.
replication
Homologous Recombination (HR) is a mechanism that repairs ______ breaks in DNA.
double strand
Non-Homologous End Joining (NHEJ) is a mechanism that repairs ______ breaks in DNA.
double strand
The mutation rate is only 1 in every ______ million bases.
100
The proof-reading activity of the DNA polymerase is the first line of defense against ______ errors.
replication
The DNA polymerase contains a 5-to-3 ______ activity and a 3-to-5 exonuclease activity or proofreading.
DNA polymerase
The Mismatch Repair Pathway (MMR) is the second line of defense for ______ errors.
replication
Double strand breaks (DSB) can be produced by ______ radiation or stalled replication forks that collapse.
ionizing
Non-homologous end Joining (NHEJ) is prone to ______ and is the most common form in mammalian.
error
The recognition of DSB is done by ______.
Ku
The recruitment of DNA-PKcs is done by ______.
Ku
DNA-PKcs replaces ______ as the protein that ‘bridges’ the two ends.
Ku
Learn about the role of homologous recombination repair in human cancers, including the BRCA-1 and BRCA-2 genes, and how mutations in these genes contribute to breast cancer. Understand the mechanism of homologous recombination repair and its significance in cancer development.
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