11 Questions
Which drug is considered the drug of choice for difficile infections?
Vancomycin
What is a common adverse effect associated with vancomycin use?
Nephrotoxicity
In which condition can teicoplanin be used as an alternative to vancomycin?
Osteomyelitis
What symptom is associated with Red man syndrome?
Chills
Which drug is given along with teicoplanin for the treatment of Enterococcal endocarditis?
Gentamicin
What is the primary mechanism of action of vancomycin and teicoplanin?
Inhibiting cell wall synthesis
Which component do vancomycin and teicoplanin bind to in order to exert their mechanism of action?
D-alanyl-D-alanine
Why are vancomycin and teicoplanin ineffective against Gram-negative organisms?
They cannot penetrate the outer cell membrane of Gram-negative bacteria
In which bacterial infections is vancomycin commonly used as an alternative drug?
MRSA infections
Apart from intravenous administration, in which specific condition is vancomycin given orally?
Pseudomembranous enterocolitis
What additional cellular component do vancomycin and teicoplanin damage, contributing to their mechanism of action?
Cell membrane
Learn about the mechanism of action of vancomycin and teicoplanin, two glycopeptide antibiotics commonly used in clinical practice. Understand how they work similarly as bactericidal agents by inhibiting cell wall synthesis through binding to the D-alanyl-D-alanine portion of peptidoglycan pentapeptide.
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