Mechanism of Action of Cardiac Glycosides

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Questions and Answers

What is the primary mechanism of action of cardiac glycosides like Digoxin in increasing contractility in the heart?

  • Inhibiting the Na+/K+- ATPase (correct)
  • Inhibiting the sarcoplasmic reticulum
  • Activating the Na+- Ca++ antiporter
  • Activating troponinC directly

What effect do calcium channel blockers (Dihydropyridines) have on contractility in the heart?

  • Increased contractility
  • Decreased contractility
  • Alteration of sodium levels
  • No effect on contractility (correct)

Which type of drugs act on Autonomic Neural Control by being Cardio-Selective β-Blockers?

  • Phosphodiestrase Inhibitors (correct)
  • Inotropic drugs
  • β-Agonists
  • Calcium Sensitizers

What is the primary mechanism of action of drugs modulating the Renin-Angiotensin-Aldosterone system (RAAS) in managing heart failure?

<p>Decreasing the effect of RAAS (D)</p> Signup and view all the answers

Which of the following is NOT a characteristic of inotropic drugs used in acute heart failure?

<p>Inhibit the Na+/K+- ATPase (A)</p> Signup and view all the answers

What role do non-dihydropyridine calcium channel blockers play in managing heart conditions?

<p>Decrease contractility (D)</p> Signup and view all the answers

Which class of CCBs has greater selectivity for vascular smooth muscle cells than for cardiac myocytes?

<p>Dihydropyridines (A)</p> Signup and view all the answers

Which class of CCBs is primarily used to treat hypertension due to their high vascular selectivity?

<p>Dihydropyridines (B)</p> Signup and view all the answers

Which CCB class can lead to reflex cardiac stimulation (tachycardia and increased inotropy) due to their powerful systemic vasodilator effects?

<p>Dihydropyridines (A)</p> Signup and view all the answers

Which class of CCBs is relatively selective for the myocardium and less effective as a systemic vasodilator drug?

<p>Non-dihydropyridines (A)</p> Signup and view all the answers

Which drug is an intermediate between verapamil and dihydropyridines, reducing arterial pressure without causing significant reflex cardiac stimulation?

<p>Diltiazem (A)</p> Signup and view all the answers

What is the primary mechanism of action of Cardiac Glycosides like Digoxin?

<p>Inhibition of cellular Na+/K+-ATPase (B)</p> Signup and view all the answers

What is the primary mechanism of action of Calcium Channel Blockers (CCBs) like Dihydropyridines?

<p>Inhibition of the voltage-gated calcium channels (A)</p> Signup and view all the answers

Which effect is NOT associated with the action of Dihydropyridines?

<p>Enhanced AV conduction (B)</p> Signup and view all the answers

What is the primary pharmacological action of Cardiac Glycosides such as Digoxin?

<p>Enhancement of sodium-potassium pump activity (D)</p> Signup and view all the answers

Which of the following is a characteristic of Non-Dihydropyridine Calcium Channel Blockers?

<p>They do not affect AV conduction (A)</p> Signup and view all the answers

Which process is NOT modulated by Autonomic Neural Control in the cardiovascular system?

<p>Local Paracrine control (B)</p> Signup and view all the answers

Inotropic drugs primarily affect which aspect of cardiac function?

<p>Contractility of the heart muscle (C)</p> Signup and view all the answers

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