Mechanism of Action of Cardiac Glycosides
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Questions and Answers

What is the primary mechanism of action of cardiac glycosides like Digoxin in increasing contractility in the heart?

  • Inhibiting the Na+/K+- ATPase (correct)
  • Inhibiting the sarcoplasmic reticulum
  • Activating the Na+- Ca++ antiporter
  • Activating troponinC directly

    • What effect do calcium channel blockers (Dihydropyridines) have on contractility in the heart?

  • Increased contractility
  • Decreased contractility
  • Alteration of sodium levels
  • No effect on contractility (correct)

    • Which type of drugs act on Autonomic Neural Control by being Cardio-Selective β-Blockers?

  • Phosphodiestrase Inhibitors (correct)
  • Inotropic drugs
  • β-Agonists
  • Calcium Sensitizers

    • What is the primary mechanism of action of drugs modulating the Renin-Angiotensin-Aldosterone system (RAAS) in managing heart failure?

    <p>Decreasing the effect of RAAS</p> Signup and view all the answers

    Which of the following is NOT a characteristic of inotropic drugs used in acute heart failure?

    <p>Inhibit the Na+/K+- ATPase</p> Signup and view all the answers

    What role do non-dihydropyridine calcium channel blockers play in managing heart conditions?

    <p>Decrease contractility</p> Signup and view all the answers

    Which class of CCBs has greater selectivity for vascular smooth muscle cells than for cardiac myocytes?

    <p>Dihydropyridines</p> Signup and view all the answers

    Which class of CCBs is primarily used to treat hypertension due to their high vascular selectivity?

    <p>Dihydropyridines</p> Signup and view all the answers

    Which CCB class can lead to reflex cardiac stimulation (tachycardia and increased inotropy) due to their powerful systemic vasodilator effects?

    <p>Dihydropyridines</p> Signup and view all the answers

    Which class of CCBs is relatively selective for the myocardium and less effective as a systemic vasodilator drug?

    <p>Non-dihydropyridines</p> Signup and view all the answers

    Which drug is an intermediate between verapamil and dihydropyridines, reducing arterial pressure without causing significant reflex cardiac stimulation?

    <p>Diltiazem</p> Signup and view all the answers

    What is the primary mechanism of action of Cardiac Glycosides like Digoxin?

    <p>Inhibition of cellular Na+/K+-ATPase</p> Signup and view all the answers

    What is the primary mechanism of action of Calcium Channel Blockers (CCBs) like Dihydropyridines?

    <p>Inhibition of the voltage-gated calcium channels</p> Signup and view all the answers

    Which effect is NOT associated with the action of Dihydropyridines?

    <p>Enhanced AV conduction</p> Signup and view all the answers

    What is the primary pharmacological action of Cardiac Glycosides such as Digoxin?

    <p>Enhancement of sodium-potassium pump activity</p> Signup and view all the answers

    Which of the following is a characteristic of Non-Dihydropyridine Calcium Channel Blockers?

    <p>They do not affect AV conduction</p> Signup and view all the answers

    Which process is NOT modulated by Autonomic Neural Control in the cardiovascular system?

    <p>Local Paracrine control</p> Signup and view all the answers

    Inotropic drugs primarily affect which aspect of cardiac function?

    <p>Contractility of the heart muscle</p> Signup and view all the answers

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