Mechanism of Action of Alcohol
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Questions and Answers

Match the following actions/effects of alcohol with their descriptions:

Enhancement of GABA effect on GABA receptors = Leads to CNS depression Inhibition of glutamate action on NMDA receptors = Causes disruption in memory, consciousness, alertness Up-regulation of NMDA receptors & voltage sensitive Ca channels = Leads to alcohol tolerance & withdrawal symptoms Myocardial contractility depression = Leads to cardiovascular depression

Match the following symptoms with their corresponding alcohol consumption levels:

Nystagmus, slurred speech, impaired judgment, ataxia = Mild-moderate amounts Respiratory depression, respiratory acidosis = Severe amounts Sedation, hypnosis, loss of consciousness = Mild-moderate amounts Hypotension, hypothermia, coma, death = Severe amounts

Match the following effects of alcohol on the nervous system with their descriptions:

Relieves anxiety, euphoria = Mild-moderate amounts CNS depression Severe CNS depression = Severe amounts CNS depression Chronic alcohol consumption = Leads to up-regulation of NMDA receptors & voltage sensitive Ca channels Acute alcohol consumption = Enhances the effect of GABA on its receptors in brain

Match the following cardiovascular effects of alcohol with their descriptions:

<p>Vasodilatation due to vasomotor center depression &amp; direct smooth muscle relaxation caused by acetaldehyde = Causes CVS depression Volume depletion = Severe amounts CVS depression Hypotension = Severe amounts CVS depression Coma, death = Severe amounts CVS depression</p> Signup and view all the answers

Match the following chronic alcohol effects with their descriptions:

<p>Up-regulation of NMDA receptors &amp; voltage sensitive Ca channels = Leads to alcohol tolerance &amp; withdrawal symptoms Causes disruption in memory, consciousness, alertness = Inhibition of glutamate action on NMDA receptors Leads to CNS depression = Enhancement of GABA effect on GABA receptors Leads to cardiovascular depression = Myocardial contractility depression</p> Signup and view all the answers

Study Notes

Actions/Effects of Alcohol

  • Inhibits impulsivity and judgment, leading to impaired decision-making
  • Disrupts communication between brain cells, causing impaired coordination and balance
  • Enhances the effects of GABA (inhibitory neurotransmitter), leading to relaxation and sedation

Symptoms of Alcohol Consumption

  • Slurred speech and impaired motor skills ( Blood Alcohol Content (BAC) > 0.08%)
  • Drowsiness, confusion, and decreased response to stimuli (BAC > 0.15%)
  • Loss of consciousness and suppressed breathing (BAC > 0.30%)

Effects of Alcohol on the Nervous System

  • Depresses the central nervous system, slowing down neural activity
  • Impairs cognitive function, memory, and learning
  • Interferes with the brain's reward system, leading to addiction

Cardiovascular Effects of Alcohol

  • Low to moderate consumption (1-2 drinks/day) reduces cardiovascular disease risk
  • High consumption (>3 drinks/day) increases blood pressure, heart rate, and cardiovascular disease risk
  • Binge drinking increases risk of cardiac arrhythmias and sudden death

Chronic Effects of Alcohol

  • Liver damage and cirrhosis due to chronic heavy drinking
  • Increased risk of certain cancers, such as liver, breast, and colon cancer
  • Nutritional deficiencies, particularly thiamine deficiency (Wernicke-Korsakoff syndrome)

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Description

This quiz covers the pharmacology of alcohol, focusing on its mechanism of action. It explores how alcohol acts as a CNS depressant and the acute effects it causes by enhancing the effect of GABA and inhibiting glutamate action on NMDA receptors.

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