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Questions and Answers
What does IC50 represent in toxicity measurements?
What does IC50 represent in toxicity measurements?
- The threshold level of exposure for chronic effects
- The maximum concentration considered safe for organisms
- The concentration at which 50% of organisms die
- Inhibitory concentration that decreases normal response by 50% (correct)
Which term refers to the organs that can be damaged by xenobiotics?
Which term refers to the organs that can be damaged by xenobiotics?
- Non-target organs
- Target organs (correct)
- Secondary organs
- Vital organs
What is the purpose of using EC50 in toxicity assessments?
What is the purpose of using EC50 in toxicity assessments?
- To determine lethal concentrations
- To measure growth rates of plants
- To report non-fatal effects (correct)
- To identify all target organs of a toxin
What characterizes a toxic effect in organisms?
What characterizes a toxic effect in organisms?
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Which of the following statements is true about IC50 and EC50?
Which of the following statements is true about IC50 and EC50?
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Study Notes
Measurement of Effects
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EC50:
- Represents the concentration at which a substance causes 50% of the maximum effect in an organism.
- Typically used for effects other than lethality.
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IC50:
- Stands for Inhibitory Concentration.
- Represents the concentration that leads to a 50% reduction in the normal response of a test organism.
- Commonly applied to measure the growth inhibition in seedlings, algae, and other biological organisms.
Types of Toxicity
- Toxic Effect:
- Refers to the adverse physiological response of an organism due to exposure to toxic substances (xenobiotics) or their metabolites.
- Specific organs affected by toxins are termed target organs, with the potential for multiple target organs for each toxic substance.
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