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Mature Mast Cells and Basophils vs Eosinophils

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Mature Mast Cells and Basophils vs Eosinophils

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Questions and Answers

What is the major arachidonic acid-derived mediator produced by the cyclooxygenase pathway in mast cells?

Prostaglandin D2 (PGD2)

Which lipid mediator is 1000-fold stronger than histamine in causing prolonged bronchoconstriction?

Leukotriene LTC4

What is the function of platelet-activating factor (PAF) in immediate hypersensitivity reactions?

It is 1000-fold stronger than histamine

What is the time frame for the late phase reaction in immediate hypersensitivity?

2 to 4 hours after immediate reaction, maximal by about 24 hours Signup and view all the answers

Which lipid mediators are part of the cyclooxygenase pathway?

Prostaglandins (PGG2, PGH2, PGE2, PGF2, PGI2) Signup and view all the answers

What is the main effect of thromboxanes in immediate hypersensitivity reactions?

Platelet activation & aggregation Signup and view all the answers

Which lipid mediator causes bronchoconstriction and vasodilation in immediate hypersensitivity reactions?

Prostaglandin D2 (PGD2) Signup and view all the answers

What is the function of leukotrienes LTC4, LTD4, and LTE4 in immediate hypersensitivity reactions?

Cause prolonged bronchoconstriction Signup and view all the answers

What is the primary role of histamine in immediate hypersensitivity reactions?

It is a preformed mediator Signup and view all the answers

Which cell types produce leukotriene LTC4 in immediate hypersensitivity reactions?

Mucosal mast cells and basophils Signup and view all the answers