10 Questions
What is the major arachidonic acid-derived mediator produced by the cyclooxygenase pathway in mast cells?
Prostaglandin D2 (PGD2)
Which lipid mediator is 1000-fold stronger than histamine in causing prolonged bronchoconstriction?
Leukotriene LTC4
What is the function of platelet-activating factor (PAF) in immediate hypersensitivity reactions?
It is 1000-fold stronger than histamine
What is the time frame for the late phase reaction in immediate hypersensitivity?
2 to 4 hours after immediate reaction, maximal by about 24 hours
Which lipid mediators are part of the cyclooxygenase pathway?
Prostaglandins (PGG2, PGH2, PGE2, PGF2, PGI2)
What is the main effect of thromboxanes in immediate hypersensitivity reactions?
Platelet activation & aggregation
Which lipid mediator causes bronchoconstriction and vasodilation in immediate hypersensitivity reactions?
Prostaglandin D2 (PGD2)
What is the function of leukotrienes LTC4, LTD4, and LTE4 in immediate hypersensitivity reactions?
Cause prolonged bronchoconstriction
What is the primary role of histamine in immediate hypersensitivity reactions?
It is a preformed mediator
Which cell types produce leukotriene LTC4 in immediate hypersensitivity reactions?
Mucosal mast cells and basophils
Learn about the characteristics and distribution of mature mast cells throughout the body, as well as the similarities and differences between basophils and eosinophils in terms of morphology, function, and presence in blood. Understand their roles in immune responses and inflammation.
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